News & Events zu eXoZymes Inc (EXOZ)EXOZeXoZymes Inc

eXoZymes Graduates from Shell GameChanger Accelerator

eXoZymes announced its graduation from the Shell GameChanger Accelerator, a multimillion-dollar, multiyear program developed in collaboration between Shell and the U.S. Department of Energy's National Laboratory of the Rockies. From 2023 to 2026, eXoZymes partnered with GCxN to advance the next generation of transformative technologies with the potential to dramatically alter the future global energy landscape. The collaboration helped advance eXoZymes' cell-free biomanufacturing platform towards commercial viability.

eXoZymes Achieves Biomanufacturing Milestone with Cayman Chemical

eXoZymes announced an important validation and de-risking milestone for its cell-free biomanufacturing platform: An independent partner, Cayman Chemical, successfully ran eXoZymes' technology at pilot scale and achieved results consistent with - and in some cases exceeding - earlier internal runs. Using eXoZymes' tech transfer package, Cayman Chemical advanced the protocol from a one-liter setup to a 100-liter pilot run, operating the reaction, downstream processing, and analysis independently. During the run, the team encountered real-world conditions - including pH variation and precipitation - which often cause enzyme-based processes to fail. Despite this, the reaction continued to perform reliably and delivered strong results, ultimately producing more than 500 grams of pharma-grade N-trans-caffeoyltyramine, or NCT, at 99.6% purity, a result that is difficult to obtain in biomanufacturing without extensive purification steps. Additionally, the 99% conversion of feedstock to end product highlights a level of efficiency that is challenging to achieve and maintain in traditional biomanufacturing. With isolated high-purity NCT now produced at pilot scale, eXoZymes is actively engaging with partners interested in formulation development, product validation, and application-specific testing. The availability of high-purity material enables partners to move beyond feasibility studies and into hands-on evaluation under relevant conditions.