Addex Therapeutics Ltd（ADXN）資訊與事件ADXNAddex Therapeutics Ltd

Addex Therapeutics' Spin-Out Neurosterix Completes Phase 1 Study of NTX-253

Addex Therapeutics announced that its spin-out company, Neurosterix, in which Addex holds a 20% equity interest, has completed its Phase 1 clinical studies evaluating NTX-253 and plans to advance NTX-253 into Phase 2 clinical development. NTX-253 is an allosteric modulator, or PAM, of the muscarinic M4 receptor being developed for the treatment of schizophrenia. The clinical study includes a multi-part, ascending-dose design intended to efficiently characterize NTX-253's clinical profile and support subsequent patient-focused development. The study includes both single ascending dose, or SAD, and multiple ascending dose, or MAD, components, incorporating key translational elements such as food-effect and cerebrospinal fluid, or CSF, assessments. The studies included both healthy volunteers and stable schizophrenia patients, and has provided important safety and pharmacokinetic data. Neurosterix was spun-out of Addex in April 2024, raising $65M in a Series A financing led by funds affiliated with Perceptive Advisors. Addex retains a 20% equity interest in Neurosterix.

Addex Therapeutics Publishes Preclinical Research on ADX71743

Addex Therapeutics announced publication of new preclinical research demonstrating that ADX71743, a selective negative allosteric modulator of metabotropic glutamate receptor 7, significantly modulates sleep-wake regulation and stress-related neurochemistry in animal models. The data, published in the International Journal of Neuropsychopharmacology, expands the growing body of evidence supporting mGlu7 as an important mechanism regulating key brain functions and a promising therapeutic target across a range of central nervous system disorders, including mood disorders, anxiety disorders, post-traumatic stress disorder, and other conditions associated with dysregulated stress responses. In the study, ADX71743 increased wakefulness while reducing both REM and non-REM sleep in rats. The compound also altered stress-induced changes in key neurotransmitters, including glutamate, GABA and monoamines, across multiple brain regions in awake animals, producing neurochemical effects consistent with modulation of stress-responsive neural circuits. Together, these findings further validate the pharmacological profile of selective mGlu7 inhibition in vivo and provide additional support for the therapeutic potential of this novel mechanism. Previous studies have demonstrated that selective mGlu7 inhibition can modulate anxiety-related behaviors, disrupt maladaptive fear memory reconsolidation and influence glutamatergic signaling in both rodent and human brain tissue.

Addex Therapeutics Reports Antitussive Activity of GABAB Modulator

Addex Therapeutics announced preclinical data demonstrating antitussive activity of its GABAB positive allosteric modulator candidate in a bleomycin-induced idiopathic pulmonary fibrosis exacerbated chronic cough model. In studies evaluating chronic once-daily administration of a lead GABAB PAM candidate in BLM-exposed animals, robust and sustained antitussive efficacy was observed, with significant reductions in cough frequency and increased cough latency over the treatment period. Improved lung pathology outcomes, including lower Ashcroft scores and reduced percentage of affected lung tissue suggesting an impact on fibrosis, were demonstrated compared to untreated BLM-exposed animals at both Day 7 and Day 28. The safety profile remained favorable, with no meaningful changes in respiratory rate, or body temperature. The compound was well tolerated throughout the study, supporting its potential for chronic administration.