Zentalis Pharmaceuticals Inc

Zentalis Pharmaceuticals Inc (ZNTL) Stock Analysis

$1.715

-0.044 (-2.56%)At close

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High
1.820
Open
1.750
VWAP
1.72
Volume
1.64M
Mkt Cap
298.26M
Low
1.630
Amount
2.83M
EV/EBITDA, TTM
0.00

Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is engaged in developing azenosertib (ZN-c3), a potentially first-in-class WEE1 inhibitor, for patients with ovarian cancer and other tumor types. The inhibition of WEE1, a DNA damage response kinase, drives cancer cells into mitosis without being able to repair damaged DNA, resulting in cell death and thereby preventing tumor growth and potentially causing tumor regression. WEE1 acts as a regulator of the G1-S and G2-M cell cycle checkpoints, through negative regulation of both CDK1 and CDK2, to prevent replication of cells with damaged DNA. In clinical trials, azenosertib has been well tolerated and has demonstrated anti-tumor activity as a single agent across multiple tumor types.

AI analysis of Zentalis Pharmaceuticals Inc (ZNTL)

Sell

Zentalis Pharmaceuticals Inc is not a good buy right now. The current price is $1.85, which is significantly below its 52-week high of $6.95, indicating a substantial decline. The RSI is at 22.255, suggesting the stock is oversold and may not recover soon. Additionally, the company has reported continuous losses, with a net income of -$42,286,000 in Q2 2026 and a forward P/E of 0, reflecting lack of earnings visibility. The main risk is the recent earnings miss, where the EPS was -$0.59, missing estimates by $0.10, which could further undermine investor confidence.

Valuation Metrics

The current forward P/E ratio for Zentalis Pharmaceuticals Inc (ZNTL) is 0.00, compared to its 5-year average forward P/E of -4.28.

Forward P/E

Overvalued
5Y Average P/E
-4.28
Current P/E
0.00
Overvalued
-0.68
Undervalued
-7.88

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-2.45
Current EV/EBITDA
0.00
Overvalued
0.77
Undervalued
-5.67

Forward P/S

Fair
5Y Average P/S
235.49
Current P/S
17.78
Overvalued
1271.09
Undervalued
-800.12

Alphio AI Price Scenarios for ZNTL

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%ZNTL

$1.76

Scenario price

B

Base

Base · 50%ZNTL

$1.53

Scenario price

B

Bear

Bear · 25%ZNTL

$1.37

Scenario price

Events Timeline

2026-10-23 (ET)

10:30:00

Zentalis Presents Overall Survival Data for Azenosertib in DENALI Study

2026-10-18 (ET)

19:00:00

Zentalis Publishes Interim Survival Data from DENALI Study

2026-08-13 (ET)

16:30:00

Zentalis Pharmaceuticals Launches Public Offering

2026-08-06 (ET)

17:30:00

Zentalis CEO Reports Progress on Azenosertib Trials

2026-05-12 (ET)

16:20:00

Zentalis CEO Reports Progress on Azenosertib for Ovarian Cancer Patients

News

ZNTL FAQ — answered by Alphio AI

Zentalis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on discovering and developing small molecule therapeutics targeting fundamental biological pathways of cancers. The Company is engaged in developing azenosertib (ZN-c3), a potentially first-in-class WEE1 inhibitor, for patients with ovarian cancer and other tumor types. The inhibition of WEE1, a DNA damage response kinase, drives cancer cells into mitosis without being able to repair damaged DNA, resulting in cell death and thereby preventing tumor growth and potentially causing tumor regression. WEE1 acts as a regulator of the G1-S and G2-M cell cycle checkpoints, through negative regulation of both CDK1 and CDK2, to prevent replication of cells with damaged DNA. In clinical trials, azenosertib has been well tolerated and has demonstrated anti-tumor activity as a single agent across multiple tumor types. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Zentalis Pharmaceuticals Inc is not a good buy right now. The current price is $1.85, which is significantly below its 52-week high of $6.95, indicating a substantial decline. The RSI is at 22.255, suggesting the stock is oversold and may not recover soon. Additionally, the company has reported continuous losses, with a net income of -$42,286,000 in Q2 2026 and a forward P/E of 0, reflecting lack of earnings visibility. The main risk is the recent earnings miss, where the EPS was -$0.59, missing estimates by $0.10, which could further undermine investor confidence.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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