Xilio Therapeutics Inc

Xilio Therapeutics Inc (XLO) Stock Analysis

$8.500

-0.205 (-2.41%)At close

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High
8.650
Open
8.450
VWAP
8.31
Volume
27.23K
Mkt Cap
34.70M
Low
7.775
Amount
226.21K
EV/EBITDA, TTM
9.10

Xilio Therapeutics, Inc. is a clinical-stage biotechnology company. The Company is engaged in discovering and developing masked immuno-oncology, or I-O, therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. Its pipeline products include Vilastobart, Efarindodekin alfa, XTX501, and masked T cell engagers. Vilastobart is an investigational masked, Fc-enhanced anti-CTLA-4 designed to block CTLA-4 and deplete regulatory T cells when activated (unmasked) in the tumor microenvironment (TME). XTX501 is a novel bispecific PD-1 / masked IL-2 designed to selectively stimulate PD-1 positive, antigen-experienced T cells and enhance their function. Its masked T cell engager programs consist of PSMA and STEAP1 with co-stimulation and CLDN18.2. The masked T cell engagers include molecules with one or more tumor-associated antigen (TAA) binding domains and a CD3 targeting domain.

xiliotx.com

AI analysis of Xilio Therapeutics Inc (XLO)

Buy

Xilio Therapeutics Inc is a good buy right now due to its recent financial turnaround, evidenced by a Q2 2026 revenue of $18.7 million, a 131% increase from the previous year, and a current price of $7.99, which is well below its 52-week high of $12.02. The company's gross margin remains strong at 100%, indicating efficient operations. However, the main risk is its net income loss of $6.37 million in Q2 2026, which highlights ongoing financial challenges.

Valuation Metrics

The current forward P/E ratio for Xilio Therapeutics Inc (XLO) is 0.00, compared to its 5-year average forward P/E of -1.35.

Forward P/E

Overvalued
5Y Average P/E
-1.35
Current P/E
0.00
Overvalued
-0.29
Undervalued
-2.41

Forward EV/EBITDA

Overvalued
5Y Average EV/EBITDA
0.97
Current EV/EBITDA
9.10
Overvalued
5.15
Undervalued
-3.22

Forward P/S

Fair
5Y Average P/S
1.25
Current P/S
1.15
Overvalued
2.92
Undervalued
-0.41

Whales holding XLO

F

Frazier Life Sciences Management, LP

+ HoldingXLO

+14.45%

3M Return

Events Timeline

2026-10-30 (ET)

11:30:00

Xilio Therapeutics Inc Trading Halted Due to Volatility Trading Pause

2026-10-26 (ET)

08:00:00

Xilio Therapeutics Doses First Patient in XTX501 Clinical Trial

2026-09-28 (ET)

08:00:00

Xilio Therapeutics Appoints Dr. Yariv Houvras as Chief Medical Officer

2026-06-29 (ET)

08:00:00

Xilio Therapeutics Appoints Ben Harshbarger as Chief Legal Officer

2026-05-12 (ET)

08:00:00

Xilio Therapeutics Files $250M Mixed Securities Shelf

News

XLO FAQ — answered by Alphio AI

Xilio Therapeutics, Inc. is a clinical-stage biotechnology company. The Company is engaged in discovering and developing masked immuno-oncology, or I-O, therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. Its pipeline products include Vilastobart, Efarindodekin alfa, XTX501, and masked T cell engagers. Vilastobart is an investigational masked, Fc-enhanced anti-CTLA-4 designed to block CTLA-4 and deplete regulatory T cells when activated (unmasked) in the tumor microenvironment (TME). XTX501 is a novel bispecific PD-1 / masked IL-2 designed to selectively stimulate PD-1 positive, antigen-experienced T cells and enhance their function. Its masked T cell engager programs consist of PSMA and STEAP1 with co-stimulation and CLDN18.2. The masked T cell engagers include molecules with one or more tumor-associated antigen (TAA) binding domains and a CD3 targeting domain. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Xilio Therapeutics Inc is a good buy right now due to its recent financial turnaround, evidenced by a Q2 2026 revenue of $18.7 million, a 131% increase from the previous year, and a current price of $7.99, which is well below its 52-week high of $12.02. The company's gross margin remains strong at 100%, indicating efficient operations. However, the main risk is its net income loss of $6.37 million in Q2 2026, which highlights ongoing financial challenges.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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