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Telomir Pharmaceuticals Announces New Data on Triple-Negative Breast Cancer

Telomir Pharmaceuticals announced new in vitro data demonstrating that Telomir-1 induces broad tumor cell mortality across biologically distinct subtypes of triple-negative breast cancer. Iron-rescue experiments confirmed that the observed tumor cell mortality is iron-dependent, directly supporting Telomir-Zn's proposed intracellular metal-modulating mechanism and distinguishing the effect from nonspecific cytotoxicity. Triple-negative breast cancer is an aggressive and molecularly heterogeneous disease lacking estrogen receptor, progesterone receptor and HER2 expression. Although chemotherapy, immunotherapy, PARP inhibitors, and antibody-drug conjugates have expanded available treatment options, outcomes in metastatic and treatment-resistant TNBC remain limited, and relapse rates remain high. Many TNBC tumors exhibit elevated intracellular iron levels and heightened oxidative stress, creating a biological reliance on redox-active metals to sustain proliferation and epigenetic modifications. Telomir-Zn is designed to modulate intracellular metal balance by reducing labile redox-active iron while increasing zinc availability. In the newly reported studies, tumor cell mortality observed across TNBC models was significantly attenuated when supplemental iron was introduced, confirming that the effect is mechanistically linked to disruption of tumor iron dependency. The study, conducted in collaboration with Pharmaseed, is evaluating five human TNBC cell lines representing distinct molecular subtypes. Three models have been completed to date: MDA-MB-468 - Near-complete tumor cell mortality at 72 hours HCC70 - Significant partial mortality MDA-MB-231 - Significant partial mortality Two additional models, BT-549 and HCC1806, are currently under evaluation. Across all completed models, supplemental iron significantly reduced Telomir-Zn-induced tumor cell death. The variability in magnitude of response across subtypes is consistent with the established biological heterogeneity of TNBC.

Telomir Pharmaceuticals Announces Telomir-Zn Cellular Study Results

Telomir Pharmaceuticals announced new cellular study results demonstrating that Telomir-1, in the form of Telomir-Zn, induces a rapid and coordinated intracellular redistribution of zinc and iron. These findings extend Telomir's previously reported intracellular iron-reduction data by directly demonstrating, for the first time, that Telomir-Zn simultaneously increases intracellular zinc while reducing redox-active ferrous iron inside living cells. The coupled nature of these effects supports a differentiated intracellular metal-modulating mechanism rather than simple extracellular metal chelation. To assess whether Telomir-Zn alters intracellular metal pools, Telomir Pharmaceuticals, in collaboration with Smart Assays Biotechnologies, has quantified labile intracellular zinc and iron levels in cultured human HaCaT cells using complementary live-cell fluorescent probes. Key observations include: Rapid, dose-dependent zinc accumulation: Telomir-Zn exposure resulted in a measurable increase in intracellular zinc within 30 minutes, sustained over a two-hour period at low-micromolar concentrations, without loss of cell confluence or viability. Reciprocal reduction of redox-active iron: Increasing Telomir-Zn concentrations were associated with progressive depletion of the intracellular ferrous iron pool, most closely linked to oxidative stress. Coordinated intracellular modulation: Zinc accumulation and iron reduction occurred over similar concentration ranges and timeframes, supporting a coordinated intracellular process rather than independent or nonspecific metal effects.