Spruce Biosciences, Inc

Spruce Biosciences, Inc (SPRB) Stock Analysis

$60.780

-2.419 (-3.98%)At close

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High
62.980
Open
62.115
VWAP
61.22
Vol
39.96K
Mkt Cap
21.90M
Low
59.895
Amount
2.45M
EV/EBITDA, TTM
0.00

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. It has a diverse portfolio of product candidates addressing diseases with high unmet medical need and clear biology for treatment, for which there are either no approved therapies treating the underlying disease or suboptimal treatment options. Its pipeline consists of TA-ERT, Tildacerfont and Cortibon, and SPR202. TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. Tildacerfont has the potential to address hyperactive brain corticotropin-releasing factors neurotransmission and aberrant functioning of the hypothalamus-pituitary-adrenal axis in patients with MDD. SPR202 focuses on the treatment of Congenital Adrenal Hyperplasia and other indications.

sprucebio.com

AI analysis of Spruce Biosciences, Inc (SPRB)

buy

Spruce Biosciences Inc is a good buy right now due to its recent price movement and positive clinical developments. The current price is $60.78, which is significantly below the analyst price target of $144 from Citizens, indicating a potential upside of 137%. Additionally, the stock has shown a strong 5-day change of +17.84% and a remarkable 1-year change of +520.20%, reflecting positive momentum. However, investors should be cautious of the negative earnings report with an EPS of -6.68, which missed estimates by 39.46%, indicating ongoing profitability challenges.

Valuation Metrics

The current forward P/E ratio for Spruce Biosciences, Inc (SPRB) is 0.00, compared to its 5-year average forward P/E of -1.34.

Forward P/E

Fair
5Y Average P/E
-1.34
Current P/E
0.00
Overvalued
0.09
Undervalued
-2.77

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
0.16
Current EV/EBITDA
0.00
Overvalued
0.66
Undervalued
-0.34

Forward P/S

Fair
5Y Average P/S
6.28
Current P/S
2.05
Overvalued
14.80
Undervalued
-2.24

Events Timeline

2026-08-26 (ET)

08:30:00

Spruce Biosciences Launches MPS3BStudy.com Website

2026-08-12 (ET)

09:30:00

Spruce CEO: Plans to Submit TA-ERT BLA in Q4

09:30:00

Spruce Cash and Cash Equivalents Reach $96.3 Million

08:30:00

Spruce Biosciences Secures $5.5M Strategic Investment

2026-08-03 (ET)

08:30:00

Spruce Biosciences Appoints Jessica Cohen Pfeffer as VP of Clinical Development

News

SPRB FAQ — answered by Alphio AI

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. It has a diverse portfolio of product candidates addressing diseases with high unmet medical need and clear biology for treatment, for which there are either no approved therapies treating the underlying disease or suboptimal treatment options. Its pipeline consists of TA-ERT, Tildacerfont and Cortibon, and SPR202. TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. Tildacerfont has the potential to address hyperactive brain corticotropin-releasing factors neurotransmission and aberrant functioning of the hypothalamus-pituitary-adrenal axis in patients with MDD. SPR202 focuses on the treatment of Congenital Adrenal Hyperplasia and other indications. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Spruce Biosciences Inc is a good buy right now due to its recent price movement and positive clinical developments. The current price is $60.78, which is significantly below the analyst price target of $144 from Citizens, indicating a potential upside of 137%. Additionally, the stock has shown a strong 5-day change of +17.84% and a remarkable 1-year change of +520.20%, reflecting positive momentum. However, investors should be cautious of the negative earnings report with an EPS of -6.68, which missed estimates by 39.46%, indicating ongoing profitability challenges.

This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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