Spruce Biosciences, Inc

Spruce Biosciences, Inc (SPRB) Stock Analysis

$42.710

-3.575 (-8.37%)At close

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High
46.575
Open
46.150
VWAP
43.93
Volume
56.17K
Mkt Cap
21.90M
Low
42.500
Amount
2.47M
EV/EBITDA, TTM
0.00

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. It has a diverse portfolio of product candidates addressing diseases with high unmet medical need and clear biology for treatment, for which there are either no approved therapies treating the underlying disease or suboptimal treatment options. Its pipeline consists of TA-ERT, Tildacerfont and Cortibon, and SPR202. TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. Tildacerfont has the potential to address hyperactive brain corticotropin-releasing factors neurotransmission and aberrant functioning of the hypothalamus-pituitary-adrenal axis in patients with MDD. SPR202 focuses on the treatment of Congenital Adrenal Hyperplasia and other indications.

sprucebio.com

AI analysis of Spruce Biosciences, Inc (SPRB)

Buy

Spruce Biosciences Inc (SPRB) is a good buy right now, trading at $44.55, significantly below its 52-week high of $129. The stock has a forward P/E of 0, indicating potential for future earnings growth as it develops its lead asset, TA-ERT, which has received favorable designations from the FDA. Analysts project a price target of $149, suggesting a potential upside of over 335% from the current price. However, the company reported a disappointing Q1 EPS of -$8.94, which missed expectations and reflects ongoing profitability challenges, presenting a risk to investors.

Valuation Metrics

The current forward P/E ratio for Spruce Biosciences, Inc (SPRB) is 0.00, compared to its 5-year average forward P/E of -1.30.

Forward P/E

Fair
5Y Average P/E
-1.30
Current P/E
0.00
Overvalued
0.15
Undervalued
-2.74

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
0.20
Current EV/EBITDA
0.00
Overvalued
0.67
Undervalued
-0.28

Forward P/S

Fair
5Y Average P/S
6.35
Current P/S
1.70
Overvalued
14.82
Undervalued
-2.13

Whales holding SPRB

C

Cable Car Capital LLC

+ HoldingSPRB

+0.00%

3M Return

Events Timeline

2026-08-26 (ET)

08:30:00

Spruce Biosciences Launches MPS3BStudy.com Website

2026-08-12 (ET)

09:30:00

Spruce Cash and Cash Equivalents Reach $96.3 Million

09:30:00

Spruce CEO: Plans to Submit TA-ERT BLA in Q4

08:30:00

Spruce Biosciences Secures $5.5M Strategic Investment

2026-08-03 (ET)

08:30:00

Spruce Biosciences Appoints Jessica Cohen Pfeffer as VP of Clinical Development

News

SPRB FAQ — answered by Alphio AI

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing therapies for neurological disorders with significant unmet medical need. It has a diverse portfolio of product candidates addressing diseases with high unmet medical need and clear biology for treatment, for which there are either no approved therapies treating the underlying disease or suboptimal treatment options. Its pipeline consists of TA-ERT, Tildacerfont and Cortibon, and SPR202. TA-ERT is a fusion protein comprised of recombinant human alpha-N-acetylglucosaminidase. TA-ERT is intended as an enzyme replacement therapy for the treatment of patients with MPS IIIB who lack rhNAGLU enzyme activity. Tildacerfont has the potential to address hyperactive brain corticotropin-releasing factors neurotransmission and aberrant functioning of the hypothalamus-pituitary-adrenal axis in patients with MDD. SPR202 focuses on the treatment of Congenital Adrenal Hyperplasia and other indications. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Spruce Biosciences Inc (SPRB) is a good buy right now, trading at $44.55, significantly below its 52-week high of $129. The stock has a forward P/E of 0, indicating potential for future earnings growth as it develops its lead asset, TA-ERT, which has received favorable designations from the FDA. Analysts project a price target of $149, suggesting a potential upside of over 335% from the current price. However, the company reported a disappointing Q1 EPS of -$8.94, which missed expectations and reflects ongoing profitability challenges, presenting a risk to investors.

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