Prelude Therapeutics Inc

Prelude Therapeutics Inc (PRLD) Stock Analysis

$4.080

+0.324 (+7.94%)At close

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High
4.160
Open
3.840
VWAP
3.99
Volume
378.92K
Mkt Cap
202.69M
Low
3.740
Amount
1.51M
EV/EBITDA, TTM
-3.03

Prelude Therapeutics Incorporated is a precision oncology company built on a foundation of drug discovery to deliver novel precision cancer medicines to underserved patients. By focusing on developing molecules using broad mechanisms that have multiple links to oncogenic driver pathways in select patients, it has developed a diverse pipeline consisting of multiple distinct programs, including kinases, targeted protein degraders, and degrader antibody conjugates. PRT12396 its lead, mutant-selective JAK2V617F inhibitor, is an open-label and multi-center study in patients with high-risk polycythemia vera and intermediate and high-risk myelofibrosis. JAK2V617F is the primary driver mutation responsible for disease progression in the majority of patients living with myeloproliferative neoplasms. The Company has discovered and is developing a series of selective and orally bioavailable KAT6A selective degraders. KAT6A is engaged in treating advanced breast cancer & other solid tumors.

preludetx.com

AI analysis of Prelude Therapeutics Inc (PRLD)

Buy

Prelude Therapeutics Inc is a good buy right now due to its current price of $3.84, which is significantly below the analyst price target of $12, indicating a potential upside of over 200%. Additionally, the stock has shown a year-to-date change of +40.66% and a one-year change of +118.18%, reflecting strong momentum. The main risk is the negative earnings per share (EPS) of -0.14 expected for the next quarter, which indicates ongoing financial challenges.

Valuation Metrics

The current forward P/E ratio for Prelude Therapeutics Inc (PRLD) is 0.00, compared to its 5-year average forward P/E of -2.06.

Forward P/E

Overvalued
5Y Average P/E
-2.06
Current P/E
0.00
Overvalued
-0.92
Undervalued
-3.20

Forward EV/EBITDA

Strongly Undervalued
5Y Average EV/EBITDA
-0.49
Current EV/EBITDA
-3.03
Overvalued
0.48
Undervalued
-1.46

Forward P/S

Strongly Overvalued
5Y Average P/S
1.01
Current P/S
8.30
Overvalued
3.30
Undervalued
-1.27

Alphio AI Price Scenarios for PRLD

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%PRLD

$1.00

Scenario price

B

Base

Base · 50%PRLD

$0.97

Scenario price

B

Bear

Bear · 25%PRLD

$0.93

Scenario price

Whales holding PRLD

B

Baker Bros. Advisors LP

+ HoldingPRLD

+12.33%

3M Return

S

Soleus Capital Management, L.P.

+ HoldingPRLD

-7.34%

3M Return

O

OrbiMed Advisors LLC

+ HoldingPRLD

-10.68%

3M Return

R

RA Capital Management, L.P.

+ HoldingPRLD

-18.42%

3M Return

Events Timeline

2026-10-13 (ET)

07:30:00

Prelude Therapeutics Announces Clinical Trial Collaboration with Eli Lilly

2026-09-10 (ET)

07:30:00

Prelude Therapeutics Receives FDA Approval for Phase 1 Study of PRT13722

2026-08-11 (ET)

07:30:00

Prelude CEO Highlights Strong Execution in First Half of 2026

2026-07-28 (ET)

11:00:00

Prelude Therapeutics Shares Rise 20% to $4.67

2026-05-12 (ET)

07:40:00

Prelude CEO States Focused Execution of Strategic Priorities

News

PRLD FAQ — answered by Alphio AI

Prelude Therapeutics Incorporated is a precision oncology company built on a foundation of drug discovery to deliver novel precision cancer medicines to underserved patients. By focusing on developing molecules using broad mechanisms that have multiple links to oncogenic driver pathways in select patients, it has developed a diverse pipeline consisting of multiple distinct programs, including kinases, targeted protein degraders, and degrader antibody conjugates. PRT12396 its lead, mutant-selective JAK2V617F inhibitor, is an open-label and multi-center study in patients with high-risk polycythemia vera and intermediate and high-risk myelofibrosis. JAK2V617F is the primary driver mutation responsible for disease progression in the majority of patients living with myeloproliferative neoplasms. The Company has discovered and is developing a series of selective and orally bioavailable KAT6A selective degraders. KAT6A is engaged in treating advanced breast cancer & other solid tumors. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Prelude Therapeutics Inc is a good buy right now due to its current price of $3.84, which is significantly below the analyst price target of $12, indicating a potential upside of over 200%. Additionally, the stock has shown a year-to-date change of +40.66% and a one-year change of +118.18%, reflecting strong momentum. The main risk is the negative earnings per share (EPS) of -0.14 expected for the next quarter, which indicates ongoing financial challenges.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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