Lineage Cell Therapeutics Inc (LCTX) News & EventsLCTXNews & EventsLineage Cell Therapeutics Inc

Lineage Cell Updates COR1 Corneal Cell Transplant Program

Lineage Cell provided an update on COR1, the Company's allogeneic corneal endothelial cell transplant program, in preclinical development for the treatment of corneal endothelial disease. With COR1, Lineage is deploying its ophthalmology and cell manufacturing expertise to achieve consistent, large-scale production of allogeneic CEnCs. COR1 is a pluripotent cell derived transplant designed to address the current deficiencies of donor-derived CEnCs, which are currently approved in Japan, including limited supply, donor variability and quality, extensive processing and handling, and brief shelf-life. The Company has successfully utilized its proprietary AlloSCOPE cell manufacturing platform to achieve seamless precursor bioreactor-based expansion and differentiation to support CEnC production which, together with a thaw-and-inject formulation, the company believes will offer a superior product profile and which meet Lineage's internal criteria for continued preclinical advancement.

Lineage Cell Sees Cash and Equivalents Funding Operations into 2Q28

Lineage Cell sees cash, equivalents funding operations into 2Q28

Lineage Reports Q1 Revenue of $1.73M, Below Consensus

Reports Q1 revenue $1.73M, consensus $3.6M. "This quarter, we continued to build on our developmental and clinical accomplishments. Most notably, we applied our proprietary cell manufacturing technology platform, AlloSCOPE(TM) (Allogeneic, Scalable, Consistent, Off-the-shelf, Pluripotent Cell Engineering), to launch COR1, our new, wholly-owned corneal endothelial cell therapy program. COR1 is a preclinical asset which we believe benefits from our existing ophthalmology and manufacturing expertise and represents a natural next application of our platform. We also achieved our first milestone with our AlloSCOPE 5D manufacturing initiative, aimed at addressing the challenges of large scale production of undifferentiated pluripotent stem cells. If successful at a larger scale, the overall goal is to leverage this initiative, together with a differentiation protocol, to address the insufficient supply of islet cells needed to support a potential treatment of Type 1 Diabetes," stated Brian M. Culley, Lineage CEO.