Bicycle Therapeutics PLC

Bicycle Therapeutics PLC (BCYC) Stock Analysis

$4.200

-0.126 (-3.00%)At close

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High
4.440
Open
4.320
VWAP
4.28
Vol
154.69K
Mkt Cap
1.40B
Low
4.190
Amount
661.54K
EV/EBITDA, TTM
0.33

Bicycle Therapeutics plc is a United Kingdom-based clinical-stage biopharmaceutical company developing a class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. The Company is evaluating zelenectide pevedotin, a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target, and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in Company-sponsored clinical trials. Additionally, the Company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology.

AI analysis of Bicycle Therapeutics PLC (BCYC)

hold

Bicycle Therapeutics PLC (BCYC) is not a strong buy right now due to ongoing financial challenges and recent earnings misses. The current price is $4.20, with a significant year-to-date decline of 37.13%. Although analysts like Oppenheimer see potential upside to $11, the company reported a Q2 EPS of -$0.72, missing expectations by $0.13, and a staggering 78.4% year-over-year revenue decline, which raises concerns about its growth trajectory.

Valuation Metrics

The current forward P/E ratio for Bicycle Therapeutics PLC (BCYC) is 0.00, compared to its 5-year average forward P/E of -6.15.

Forward P/E

Overvalued
5Y Average P/E
-6.15
Current P/E
0.00
Overvalued
-1.79
Undervalued
-10.51

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-2.14
Current EV/EBITDA
0.33
Overvalued
4.95
Undervalued
-9.23

Forward P/S

Fair
5Y Average P/S
39.24
Current P/S
45.31
Overvalued
65.86
Undervalued
12.61

Alphio AI Price Scenarios for BCYC

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%BCYC

$7.67

Scenario price

B

Base

Base · 50%BCYC

$7.15

Scenario price

B

Bear

Bear · 25%BCYC

$6.21

Scenario price

Whales holding BCYC

B

Baker Bros. Advisors LP

+ HoldingBCYC

+18.95%

3M Return

L

Long Focus Capital Management LLC

+ HoldingBCYC

+1.37%

3M Return

Events Timeline

2026-04-30 (ET)

07:10:00

Bicycle Reports Q1 Revenue of $887K, Below Consensus

2026-04-20 (ET)

07:20:00

Bicycle Therapeutics Updates EphA2 Pipeline Data

2026-03-17 (ET)

07:10:00

Bicycle Therapeutics Q4 Revenue $47.96M, Exceeds Expectations

2026-02-03 (ET)

07:30:00

Bicycle Appoints Michael Skynner as Chief Scientific Officer

07:30:00

Bicycle Therapeutics Appoints New CFO

News

BCYC FAQ — answered by Alphio AI

Bicycle Therapeutics plc is a United Kingdom-based clinical-stage biopharmaceutical company developing a class of medicines, referred to as Bicycle molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. The Company is evaluating zelenectide pevedotin, a Bicycle Toxin Conjugate (BTC) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BTC targeting EphA2, a historically undruggable target, and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist (Bicycle TICA) targeting Nectin-4 and agonizing CD137, in Company-sponsored clinical trials. Additionally, the Company is developing Bicycle Radio Conjugates (BRC) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle technology to develop therapies for diseases beyond oncology. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Bicycle Therapeutics PLC (BCYC) is not a strong buy right now due to ongoing financial challenges and recent earnings misses. The current price is $4.20, with a significant year-to-date decline of 37.13%. Although analysts like Oppenheimer see potential upside to $11, the company reported a Q2 EPS of -$0.72, missing expectations by $0.13, and a staggering 78.4% year-over-year revenue decline, which raises concerns about its growth trajectory.

This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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