Alnylam Pharmaceuticals, Inc.

Alnylam Pharmaceuticals, Inc. (ALNY) Stock Analysis

$230.710

-2.561 (-1.11%)At close

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High
238.960
Open
237.730
VWAP
233.07
Volume
1.51M
Mkt Cap
31.24B
Low
229.540
Amount
350.81M
EV/EBITDA, TTM
23.81

Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults ; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Zilebesiran, Elebsiran, Mivelsiran, ALN-6400, and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.

AI analysis of Alnylam Pharmaceuticals, Inc. (ALNY)

Buy

Alnylam Pharmaceuticals appears to be a good buy at the current price of $231.83, especially considering its strong revenue growth of 74% year-over-year, reaching $1.17 billion in the latest quarter. The stock has also shown resilience, recovering approximately 25% since July, despite being down 35% year-to-date. The main risk is its high debt-to-equity ratio of 201.69%, which could affect financial stability if not managed properly.

Analyst Ratings (18)

+107.85% upside
Buy
13 Buy
4 Hold
1 Sell
Current: 230.71
Low
351.00
Average
479.53
High
580.00

BofA

2026-10-09

Price Target

$336

Buy

RBC Capital

2026-10-08

Price Target

$345

Outperform

JPMorgan

2026-09-30

Price Target

$369

Overweight

Jefferies

2026-09-08

Price Target

$260

Hold

Jefferies

2026-08-28

Price Target

$230

Hold

Valuation Metrics

The current forward P/E ratio for Alnylam Pharmaceuticals, Inc. (ALNY) is 19.68, compared to its 5-year average forward P/E of -33.43.

Forward P/E

Fair
5Y Average P/E
-33.43
Current P/E
19.68
Overvalued
43.48
Undervalued
-110.35

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-7385.24
Current EV/EBITDA
23.81
Overvalued
51012.19
Undervalued
-65782.66

Forward P/S

Undervalued
5Y Average P/S
12.84
Current P/S
4.52
Overvalued
17.31
Undervalued
8.38

Alphio AI Price Scenarios for ALNY

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%ALNY

$422.33

Scenario price

B

Base

Base · 50%ALNY

$289.06

Scenario price

B

Bear

Bear · 25%ALNY

$182.69

Scenario price

Whales holding ALNY

L

Loomis, Sayles & Company L.P.

+ HoldingALNY

+12.07%

3M Return

W

Wanjia Asset Management Co., Ltd.

+ HoldingALNY

+11.25%

3M Return

G

Gilder Gagnon Howe & Co. LLC

+ HoldingALNY

+7.50%

3M Return

E

Entropy Technologies, LP

+ HoldingALNY

+7.20%

3M Return

T

Traynor Capital Management, Inc.

+ HoldingALNY

+4.27%

3M Return

T

Tremblant Advisors LP

+ HoldingALNY

+2.94%

3M Return

ALNY FAQ — answered by Alphio AI

Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults ; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Zilebesiran, Elebsiran, Mivelsiran, ALN-6400, and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Alnylam Pharmaceuticals appears to be a good buy at the current price of $231.83, especially considering its strong revenue growth of 74% year-over-year, reaching $1.17 billion in the latest quarter. The stock has also shown resilience, recovering approximately 25% since July, despite being down 35% year-to-date. The main risk is its high debt-to-equity ratio of 201.69%, which could affect financial stability if not managed properly.

18 analysts cover ALNY: 13 rate it Buy, 4 Hold and 1 Sell. The average price target is 479.53.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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