Agios Pharmaceuticals, Inc.

Agios Pharmaceuticals, Inc. (AGIO) Stock Analysis

$33.680

+0.364 (+1.08%)At close

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High
33.865
Open
33.090
VWAP
33.49
Vol
1.11M
Mkt Cap
2.48B
Low
32.928
Amount
37.16M
EV/EBITDA, TTM
-2.23

Agios Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on developing and delivering transformative therapies for patients living with rare diseases. It markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for debilitating hemolytic anemia. Its lead product candidate in its portfolio, PYRUKYND (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. It is also developing tebapivat, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndromes, or LR MDS, and hemolytic anemias; AG-181, its phenylalanine hydroxylase, or PAH, stabilizer for the potential treatment of phenylketonuria, or PKU; and AG-236, an siRNA in-licensed from Alnylam Pharmaceuticals, Inc., targeting the transmembrane serine protease 6, or TMPRSS6 gene for the potential treatment of polycythemia vera, or PV.

www.agios.com

AI analysis of Agios Pharmaceuticals, Inc. (AGIO)

buy

Agios Pharmaceuticals appears to be a good buy right now, primarily due to its significant revenue growth of 259.1% year-over-year in Q2 2026, reaching $44.75 million, which exceeded expectations by $18.05 million. Additionally, the forward P/E ratio is notably low at 2.47, suggesting that the stock may be undervalued relative to its future earnings potential. However, a key risk is the net loss of $100.7 million reported in Q2, indicating ongoing profitability challenges.

Analyst Ratings (11)

+7.30% upside
Buy
9 Buy
2 Hold
0 Sell
Current: 33.68
Low
25.00
Average
36.14
High
62.00

Citi

2026-07-31

Price Target

$52

Buy

H.C. Wainwright

2026-07-30

Price Target

$55

Buy

H.C. Wainwright

2026-07-21

Price Target

$52

Buy

BofA

2026-07-07

Price Target

$46

Buy

Truist

2026-07-07

Price Target

$41

Buy

Valuation Metrics

The current forward P/E ratio for Agios Pharmaceuticals, Inc. (AGIO) is 2.47, compared to its 5-year average forward P/E of -0.69.

Forward P/E

Fair
5Y Average P/E
-0.69
Current P/E
2.47
Overvalued
6.71
Undervalued
-8.09

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-1.71
Current EV/EBITDA
-2.23
Overvalued
-0.51
Undervalued
-2.92

Forward P/S

Undervalued
5Y Average P/S
51.26
Current P/S
5.66
Overvalued
91.91
Undervalued
10.61

Alphio AI Price Scenarios for AGIO

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%AGIO

$39.98

Scenario price

B

Base

Base · 50%AGIO

$38.93

Scenario price

B

Bear

Bear · 25%AGIO

$35.23

Scenario price

Whales holding AGIO

R

Rock Springs Capital Management LP

+ HoldingAGIO

+21.29%

3M Return

A

Armistice Capital LLC

+ HoldingAGIO

+16.64%

3M Return

A

ADAR1 Capital Management, LLC

+ HoldingAGIO

+1.71%

3M Return

Events Timeline

2026-07-21 (ET)

09:31:00

Stock Futures Rise as Tech Shares Lead Gains

08:30:00

Agios Pharmaceuticals Down 13% to $34.75 on Tebapivat Trial Results

07:30:00

Agios Pharmaceuticals Halts Tebapivat Development in Sickle Cell Disease

2026-07-07 (ET)

12:30:00

Agios Pharmaceuticals Stock Rises 13.5% to $42.43

12:00:00

Leerink: Agios mitapivat Receives FDA Priority Review

News

AGIO FAQ — answered by Alphio AI

Agios Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on developing and delivering transformative therapies for patients living with rare diseases. It markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for debilitating hemolytic anemia. Its lead product candidate in its portfolio, PYRUKYND (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. It is also developing tebapivat, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndromes, or LR MDS, and hemolytic anemias; AG-181, its phenylalanine hydroxylase, or PAH, stabilizer for the potential treatment of phenylketonuria, or PKU; and AG-236, an siRNA in-licensed from Alnylam Pharmaceuticals, Inc., targeting the transmembrane serine protease 6, or TMPRSS6 gene for the potential treatment of polycythemia vera, or PV. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Agios Pharmaceuticals appears to be a good buy right now, primarily due to its significant revenue growth of 259.1% year-over-year in Q2 2026, reaching $44.75 million, which exceeded expectations by $18.05 million. Additionally, the forward P/E ratio is notably low at 2.47, suggesting that the stock may be undervalued relative to its future earnings potential. However, a key risk is the net loss of $100.7 million reported in Q2, indicating ongoing profitability challenges.

11 analysts cover AGIO: 9 rate it Buy, 2 Hold and 0 Sell. The average price target is 36.14.

This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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