Agios Pharmaceuticals, Inc.

Agios Pharmaceuticals, Inc. (AGIO) Stock Analysis

$31.320

-0.968 (-3.09%)At close

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High
32.515
Open
32.350
VWAP
31.67
Volume
952.68K
Mkt Cap
2.48B
Low
31.160
Amount
30.17M
EV/EBITDA, TTM
-2.09

Agios Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on developing and delivering transformative therapies for patients living with rare diseases. It markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for debilitating hemolytic anemia. Its lead product candidate in its portfolio, PYRUKYND (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. It is also developing tebapivat, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndromes, or LR MDS, and hemolytic anemias; AG-181, its phenylalanine hydroxylase, or PAH, stabilizer for the potential treatment of phenylketonuria, or PKU; and AG-236, an siRNA in-licensed from Alnylam Pharmaceuticals, Inc., targeting the transmembrane serine protease 6, or TMPRSS6 gene for the potential treatment of polycythemia vera, or PV.

www.agios.com

AI analysis of Agios Pharmaceuticals, Inc. (AGIO)

Buy

Agios Pharmaceuticals is a good buy right now due to its significant revenue growth of 259.1% year-over-year in Q2, reaching $44.75 million, and a favorable forward P/E ratio of 2.47, suggesting potential undervaluation. However, the main risk is the negative net income of $100.7 million in Q2, which indicates ongoing profitability challenges.

Analyst Ratings (11)

+15.39% upside
Buy
9 Buy
2 Hold
0 Sell
Current: 31.32
Low
25.00
Average
36.14
High
62.00

Truist

2026-10-07

Price Target

$37

Buy

BofA

2026-09-21

Price Target

$50

Buy

Citi

2026-07-31

Price Target

$52

Buy

H.C. Wainwright

2026-07-30

Price Target

$55

Buy

H.C. Wainwright

2026-07-21

Price Target

$52

Buy

Valuation Metrics

The current forward P/E ratio for Agios Pharmaceuticals, Inc. (AGIO) is 2.47, compared to its 5-year average forward P/E of -0.46.

Forward P/E

Fair
5Y Average P/E
-0.46
Current P/E
2.47
Overvalued
6.89
Undervalued
-7.81

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-1.70
Current EV/EBITDA
-2.09
Overvalued
-0.50
Undervalued
-2.89

Forward P/S

Undervalued
5Y Average P/S
46.02
Current P/S
5.33
Overvalued
77.90
Undervalued
14.15

Alphio AI Price Scenarios for AGIO

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%AGIO

$39.98

Scenario price

B

Base

Base · 50%AGIO

$38.93

Scenario price

B

Bear

Bear · 25%AGIO

$35.23

Scenario price

Whales holding AGIO

S

SCS Capital Management LLC

+ HoldingAGIO

+0.15%

3M Return

E

Erste Asset Management GmbH

+ HoldingAGIO

-0.82%

3M Return

A

Armistice Capital LLC

+ HoldingAGIO

-8.20%

3M Return

R

Rock Springs Capital Management LP

+ HoldingAGIO

-12.27%

3M Return

A

ADAR1 Capital Management, LLC

+ HoldingAGIO

-16.51%

3M Return

Events Timeline

2026-07-21 (ET)

09:31:00

Stock Futures Rise as Tech Shares Lead Gains

08:30:00

Agios Pharmaceuticals Down 13% to $34.75 on Tebapivat Trial Results

07:30:00

Agios Pharmaceuticals Halts Tebapivat Development in Sickle Cell Disease

2026-07-07 (ET)

12:30:00

Agios Pharmaceuticals Stock Rises 13.5% to $42.43

12:00:00

Leerink: Agios mitapivat Receives FDA Priority Review

News

AGIO FAQ — answered by Alphio AI

Agios Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on developing and delivering transformative therapies for patients living with rare diseases. It markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for debilitating hemolytic anemia. Its lead product candidate in its portfolio, PYRUKYND (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. It is also developing tebapivat, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndromes, or LR MDS, and hemolytic anemias; AG-181, its phenylalanine hydroxylase, or PAH, stabilizer for the potential treatment of phenylketonuria, or PKU; and AG-236, an siRNA in-licensed from Alnylam Pharmaceuticals, Inc., targeting the transmembrane serine protease 6, or TMPRSS6 gene for the potential treatment of polycythemia vera, or PV. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Agios Pharmaceuticals is a good buy right now due to its significant revenue growth of 259.1% year-over-year in Q2, reaching $44.75 million, and a favorable forward P/E ratio of 2.47, suggesting potential undervaluation. However, the main risk is the negative net income of $100.7 million in Q2, which indicates ongoing profitability challenges.

11 analysts cover AGIO: 9 rate it Buy, 2 Hold and 0 Sell. The average price target is 36.14.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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