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ZYME-News
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Faeth Therapeutics Appoints Adam Schayowitz to Board of Directors
Faeth Therapeutics (FTH) announced the appointment of Adam Schayowitz, Ph.D., MBA, to its Board of Directors. Dr. Schayowitz is Executive Vice President and Head of Research and Development at Zymeworks (ZYME).
Zymeworks Presents ZW191 Clinical Data at ESMO 2026
Zymeworks presented new clinical data from the randomized dose-optimization portion of its ongoing Phase 1 study evaluating ZW191, a FRalpha-targeting antibody-drug conjugate, ADC, at the European Society for Medical Oncology, ESMO, Congress 2026 in Madrid, Spain. The presentation highlights compelling anti-tumor activity in heavily pretreated patients with platinum-resistant ovarian cancer, including patients with high-grade serous disease across all levels of FRalpha expression. Key highlights: ZW191 demonstrates compelling anti-tumor activity in heavily pretreated patients with platinum-resistant ovarian cancer across folate receptor alpha expression levels; Confirmed objective response rates of 64.5% at the 6.4 mg/kg dose in patients with high-grade serous platinum-resistant ovarian cancer; Median duration of response not yet reached at either dose level at median 7 months follow-up, with six-month progression-free survival rate of 61% in both groups; Favorable tolerability profile, particularly at 6.4 mg/kg, supports continued clinical development in partnership or through a strategic collaboration
Zymeworks Presents ZW191 Clinical Data at ESMO 2026
Zymeworks presented new clinical data from the randomized dose-optimization portion of its ongoing Phase 1 study evaluating ZW191, a FRalpha-targeting antibody-drug conjugate, ADC, at the European Society for Medical Oncology, ESMO, Congress 2026 in Madrid, Spain. Key highlights: ZW191 demonstrates compelling anti-tumor activity in heavily pretreated patients with platinum-resistant ovarian cancer across folate receptor alpha expression levels; Confirmed objective response rates of 64.5% at the 6.4 mg/kg dose in patients with high-grade serous platinum-resistant ovarian cancer; Median duration of response not yet reached at either dose level at median 7 months follow-up, with six-month progression-free survival rate of 61% in both groups; Favorable tolerability profile, particularly at 6.4 mg/kg, supports continued clinical development in partnership or through a strategic collaboration
Zymeworks Enters Global License Agreement with Roche for ZW209
Zymeworks (ZYME) announced that it has entered into a global license and collaboration agreement with Roche (RHHBY) for the research, development and commercialization of ZW209, a T cell engager targeting DLL3. Under the agreement, Zymeworks is eligible to receive an upfront payment of $55M, a $40M payment upon initiation of the Phase 1b trial, and additional development, commercial and sales-based milestone payments of up to $718 million, and tiered high single digit to mid-teen royalties on future net sales of any approved medicines resulting from the collaboration. The transaction remains subject to the expiration or termination of the applicable waiting period under the HSR Act, as well as the satisfaction of other customary closing conditions and, where applicable, receipt of other required regulatory approvals. Zymeworks will conduct the Phase 1a monotherapy trial of ZW209 in collaboration with Roche, bringing together Zymeworks' expertise in multispecific antibody therapeutics with Roche's global capabilities in the research, development, manufacturing and commercialization of cancer medicines. Roche will fund the Phase 1a trial and be responsible for subsequent global development and commercialization of ZW209. Under the agreement, Roche will have the exclusive right to develop and commercialize ZW209 globally.
Major Averages Decline as Oil Prices Come into Focus
The major averages had a down day to start the week, with oil prices in focus after President Donald Trump rejected conditions for a ceasefire presented by Iran. Meanwhile, Treasury yields continued to climb to multi-year highs amid expectations that higher energy prices could put further pressure on inflation and increase the likelihood of additional rate hikes.Get caught up quickly on the top news and calls moving stocks with these five Top Five lists.1. STOCK NEWS:Nvidiahas launched an agent safety platform following recent security incidents and authorized an additional $150B under its existing share repurchase programMongoDBCEO Chirantan Desai has left the company to take on the role as Meta'sEnterprise Platform OfficerBoeinghas discovered a glitch to the 737 MAX software that could cause its automated navigation feature to fail, WSJ reportsBrixmorand Everview Partners agreed to acquire Slate Grocery REITfor $2.34BJana Partners is pushing Fiservto more than double planned cost reductions, Reuters reports2. WALL STREET CALLS:Royal Caribbeanupgraded to Buy at both Deutsche Bank and BofARobloxdowngraded to Underperform at JefferiesPark Hotelsupgraded to Strong Buy from Market Perform at Raymond JamesPepsiCodowngraded to Hold from Buy at Deutsche BankSweetgreenupgraded to Overweight at Wells Fargo3. AROUND THE WEB:The White House is weighing broader use of tax-exempt red-dyed diesel as an alternative to restricting exports, Reuters reportsTrump is expected to announce a $15B Mesabi Metallics steel factory in Iowa, Bloomberg saysAirbusand Leonardoare investigating a coatings defect affecting about 500 A321neo jets, Reuters reportsFugazi Research said in a new research report that the firm considers Greenland Energy'sstock "uninvestable" at "any price above zero"A EUR 10.3B bid by BASFfor Evonikhas been rejected as too low to warrant negotiations, setting up a potential takeover battle as Evonik pursues restructuring and divestitures amid broader consolidation in Europe's challenged chemicals industry, FT reports4. MOVERS:Kodiak Sciencessurged after announcing its Phase 3 DAYBREAK study met its primary endpointsBurford Capitalincreased after issuing comments related to the patent matter between Apple and TactionGE Aerospaceslipped after Bloomberg reported the FAA intends to delay certification of Boeing's 737 Max 10 aircraft as it reviews a potential issue with software developed by GE AerospaceGold Fieldsfell in New York after announcing its offer was rejected by Northern Star Resources boardNubankwas lower in New York after Bloomberg reported the company is in talks to acquire Monzo Bank for GBP8B-GBP10B5. EARNINGS/GUIDANCE:Zymeworksprovided guidance for FY26NetSol Technologiesreported Q4 results, with EPS and revenue higher year-over-yearGray Mediaannounced its outlook for Q3Kandi Technologiesreported results for H1, with EPS and revenue higher year-over-yearVestisreaffirmed its guidance for FY26INDEXES:The Dow fell 347.11, or 0.67%, to 51,481.51, the Nasdaq lost 248.34, or 0.92%, to 26,820.38, and the S&P 500 declined 59.72, or 0.77%, to 7,683.69.
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