Ionis Pharmaceuticals Inc

Ionis Pharmaceuticals Inc (IONS) News & Events

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IONS News

IONS Events

8/28 09:00

AstraZeneca and Ionis Trial Fails to Meet Primary Efficacy Endpoint

The CARDIO-TTRansform trial investigating eplontersen in patients with transthyretin-mediated amyloid cardiomyopathy did not meet its primary efficacy endpoint, according to results presented at the European Society of Cardiology Congress. The primary endpoint was a composite of cardiovascular mortality and recurrent cardiovascular events. There were 381 primary endpoint events in 210 patients receiving eplontersen compared with 392 events in 231 patients receiving placebo. Eplontersen produced suppression of circulating serum TTR, consistent with the expected pharmacodynamic effect of TTR gene silencing, as assessed by a prespecified exploratory endpoint through Week 140. The trial was funded by AstraZeneca (AZN) and Ionis Pharmaceuticals (IONS). Shares of Ionis are down 2% to $61.43 in premarket trading. Alnylam (ALNY), which is also developing a treatment for transthyretin amyloidosis with cardiomyopathy, is down 5% to $224.01.

8/27 10:30

Trump Considers New Semiconductor Tariffs Impacting Multiple Companies

Catch up on the top industries and stocks that were impacted, or were predicted to be impacted, by the comments, actions and policies of President Donald Trump with this daily recap compiled by The Fly.SEMICONDUCTOR TARIFFS:The Trump administration is considering broad new semiconductor tariffs that could extend to chip-containing products such as laptops and data-center servers, potentially raising AI infrastructure costs while linking tariff relief to U.S. manufacturing investment, Politico's Ari Hawkins and Gabby Miller. The administration is also mulling a phase-in period for the new tariffs, people familiar with the matter say. Publicly traded companies in the space include AMD, Intel, Marvell, Microchip, Micron, Nvidia, Qualcommand Texas Instruments.GRID EQUIPMENT:President Trump signed an emergency order that bars the U.S. purchase or installation of certain foreign-made, bulk-power system electrical equipment, and associated software, where it could pose cybersecurity or operational risks, Jennifer Dlouhy of Bloomberg, citing a White House official. Publicly traded companies in the solar space include Array Technologies, Canadian Solar, Emeren, Enphase Energy, FTC Solar, First Solar, JinkoSolar, Maxeon Solar, Shoals Technologies, SolarEdge, SunPowerand Sunrun.DRUG PRICING DEALS:The Trump administration is set to announce new drug pricing agreements with several midsized biotechs, trading Medicaid discounts tied to international prices for exemptions from certain Medicare pricing pilots and, in some cases, tariff relief, Bloomberg's Nyah Phengsitthy, Rachel Cohrs Zhang, and Madison Muller. Publicly traded companies in the space include Neurocrine Biosciences, Exelixis, Alnylam, BioMarin, United Therapeutics, Ionis, Bio-Techne, and Alkermes.DATA-SHARING DEALS:The Trump administration has struck data-sharing deals with OpenAI, Google, Meta, Amazon, and other tech companies to track how AI is affecting jobs and hiring, Courtenay Brown of Axios. The Labor Department has signed memorandums of understanding with "a lot of these tech companies," acting Labor Secretary Keith Sonderling told Axios.

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