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Contineum Therapeutics Inc Trading Halted
Contineum Therapeutics Inc trading halted, volatility trading pause
Anthropic CEO Warns of Out-of-Control AI, Tech Stocks Plunge
"Pacing the frontier" of AI development, expressed by the CEO of Anthropic in a high-profile blog post this weekend ,was added to the wall of worry for investors, sending the industries within the Tech sector most exposed to AI sharply lower on Monday. While the issues of higher oil prices due to Middle East instability and rising interest rates remain concerning, the debate over the threat of out-of-control AI was top of mind for the markets today. Semiconductors, Computer Hardware, Memory, and Semi Equipment names were uniformly sold off. Conversely, SaaS and Infrastructure Software stocks, along with IT Services - areas of the Tech sector thought to be under duress from the consequences of a speedy AI buildout - outperformed, with especially pronounced strength among cybersecurity stocks as traders recalibrated expectations of demand in the event that some of the more nefarious risks of AI development without guardrails came to pass. Rotation out of Tech also benefited the traditional defensive sectors Consumer Staples and Healthcare.In the opening hour of the evening session, index futures are flat as AI panic may have subsided into the close. Commodities trading saw continued strength in Energy - WTI Crude Oil was back above $102 per barrel as Iran's top security official contradicted President Trump's remarks that Tehran is clamoring for a deal to resolve the standoff in the Strait of Hormuz. In metals, gold and silver tested multi-week lows as US dollar advance was supported by building expectations of a Fed rate hike this week and Treasury yields making fresh highs across the curve.Check out this evening's top movers from around Wall Street, compiled by The Fly.HIGHER AFTER EARNINGS -Radiant Logisticsup 9.6%ALSO HIGHER -Boot Barn Holdingsup 1.5% after positive Q2 pre-announcement ahead of investor conferencesDOWN AFTER EARNINGS -Dave & Buster's Entertainmentdown 11.9%Kestra Medical Technologiesdown 8.7%The Children's Placedown 0.8%ALSO LOWER -Enova Internationaldown 18.8% after withdrawing application for Grasshopper dealContineum Therapeuticsdown 4.1% after announcing MOONLIGHT-1 trial did not achieve endpointTORM plcdown 3.5% after equity offering
Johnson & Johnson Announces MOONLIGHT-1 Trial Did Not Achieve Primary Efficacy Endpoint
The company states: "Contineum Therapeutics announced that the MOONLIGHT-1 trial did not achieve its primary efficacy endpoint. The trial evaluated improvement from baseline in the Montgomery-Asberg Depression Rating Scale total score at Day 5 compared with placebo. JNJ-5120/PIPE-307 was well-tolerated with no new safety signals. JNJ-5120/PIPE-307 is being developed by Johnson & Johnson under a global license and development agreement. Johnson & Johnson continues to evaluate the trial data, including data related to prespecified exploratory endpoints, and assess the totality and clinical relevance of the findings to inform next steps for JNJ-5120/PIPE-307. The Phase 2, MOONLIGHT-1 study is a randomized, double-blind, multicenter, placebo-controlled, proof-of-concept trial evaluating the efficacy, safety and tolerability of JNJ-5120/PIPE-307 as monotherapy in adult participants with MDD."
Contineum Falls 11% After MOONLIGHT-1 Trial Fails to Achieve Endpoint
Contineum down 11% atter MOONLIGHT-1 trial did not achieve endpoint
Contineum Cash Resources Sufficient Through Mid-2029
Cash, cash equivalents and marketable securities were $236.6 million as of June 30, 2026. Contineum believes its cash resources are sufficient to fund its planned operations through mid-2029. "We continue to expand our footprint for PROPEL-IPF, a global Phase 2 trial evaluating PIPE-791 for the treatment of patients with idiopathic pulmonary fibrosis (IPF), with more than 55 sites now online in eight countries to enable a steady pace of enrollment," said Carmine Stengone, CEO, Contineum Therapeutics. "In addition, Johnson & Johnson completed enrollment last month for its Phase 2 MOONLIGHT-1 trial of JNJ-5120/PIPE-307 in patients with major depressive disorder (MDD)."
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