Novartis AG（NVS）資訊與事件NVSNovartis AG

Abogen Biosciences Enters $575M Agreement with Novartis

Abogen Biosciences, a clinical-stage biotechnology group pioneering RNA innovation, announced that it has entered into a licensing and option agreement with Novartis to advance RNA-encoded therapeutics. The agreement includes an exclusive worldwide license to Abogen's lead asset, ABO2203, as well as options to exclusively license other potential programs leveraging Abogen's proprietary RNA platform. Under the agreement, Novartis will also have the exclusive option to license a number of next-generation therapeutic assets developed on Abogen's RNA platform. Under the terms of the proposed agreement, Abogen will receive an upfront payment of $575M and, if all options on all programs are exercised, Abogen is eligible to receive up to approximately $7.2B in potential milestone payments, subject to the achievement of agreed development, regulatory and commercial milestones. In addition, Abogen may be eligible to receive potential royalties on future product sales. The transaction is subject to customary closing conditions, including required regulatory clearances. "Achieving effective and durable immune reset remains an important goal across a number of autoimmune diseases," said Fiona Marshall, President of Biomedical Research at Novartis. "mRNA-encoded T-cell engagers represent an innovative approach that could complement existing therapeutic modalities by enabling in vivo production of these molecules. We look forward to further developing the potential of ABO2203 and additional possible applications of Abogen's RNA platform."

Trump Announces U.S. Agreement with Greenland for Security Control

Catch up on the top industries and stocks that were impacted, or were predicted to be impacted, by the comments, actions and policies of President Donald Trump with this daily recap compiled by The Fly.GREENLAND DEAL:President Donald Trump said on Friday via Truth Social, "I am pleased to announce that the United States of America has entered into an Agreement with The Kingdom of Denmark, and Greenland, that gives the United States permanent control over security, and all other needs, in Greenland, completely addressing ALL of our many U.S. concerns. There will be NO COST to the United States! At my direction, we worked with representatives of Denmark and Greenland to guarantee that the United States will FOREVER have the complete ability to do what is necessary in Greenland in order to secure and defend the security of Greenland, and the United States of America. Additionally, from now on, no U.S. adversary can EVER have a base in Greenland, have a military presence in Greenland, or make sensitive investments in Greenland, without our express written approval. For over 100 years, Presidents have known the strategic importance of Greenland, but NONE of them were able to do anything about it. I am proud to be the President that permanently and conclusively addressed this very important situation. This is an "Infinite Life" Agreement, there is no end! We are very honored and proud of what has just taken place, and everything agreed to today will be cherished by the American People. We will immediately begin the process of developing a large Military presence in the appropriate part of Greenland, of which there are many. We will work with the people of Greenland in its development and construction. This solution is a great one for the United States of America, Denmark, Greenland, and all of our Allies. We look forward to working with the wonderful people of Denmark and Greenland toward a magnificent future with respect to this large, and highly strategic, parcel of land. We will be very protective of it! This is a dream come true for the United States of America, one that is very important, historic, and special. Thank you for your attention to this matter!"Clear Street expects Critical Metalsshares to be up over 10% this morning due to the Trump administration announcing the U.S. has reached a military security deal with Greenland and Denmark. While additional details have not been released, this is progress in de-escalating the prior rhetoric from the Trump Administration about the U.S. interest in Greenland, the analyst tells investors in a research note. Clear Street says that if a formal agreement is reached, it could help accelerate Critical Metals' investment plan and phases of its Tanbreez project for rare earths mining in Greenland. The firm has a Buy rating on the stock with a $20 price target.AI FORCE:In a post on Truth Social, President Trump stated, "Over the years, there have been many Hoaxes, all generated by the Radical Left Dumocrats, for purposes of destroying our Country. RUSSIA, RUSSIA, RUSSIA, UKRAINE, UKRAINE, UKRAINE, Global Warming, Impeachment Hoax #1, Impeachment Hoax #2, Men in Women's Sports, Transgender for Everyone, and now, the decimation, or destruction, of AI, commonly known as Artificial Intelligence - And I, as President of the United States, will not stand by and let this happen. It all began with an attack on our Data Centers, until people realized how wealthy and prestigious they were for the Communities in which they were built. Higher Salaries, Lower Taxes, and Safer Streets, was the result, and the crazed Data Center attack has largely failed, so now, in much the same way as they changed the term "Global Warming" to "Climate Change," in that it covers a much larger "territory" of doubt, they are going straight at AI. We will not in any way hinder or stifle the Growth of this incredible Industry. Rather, we will cherish it, help it, and watch over it, as it grows! However, we will also be looking for BAD, and we can do that, very easily, with our already existing Criminal and Civil Justice System. For this purpose, I am forming the AI Force, much like I did Space Force, which has been a tremendous SUCCESS, in my First Term. To that end, I will be announcing, in the near future, the AI "Czar" - Only High I.Q. individuals need apply! AI is the next Industrial Revolution, or Internet, but will be even larger and more impactful, possibly as much as 25% of our Country's GDP. We are leading China, and the rest of the World, and I intend to keep it that way! President DONALD J. TRUMP".MEDIA BAN:President Donald Trump stated in a post to Truth Social, "I am proud to announce that, effective immediately, I am banning Fake News CNN, MSNOW (who recently changed their name from MSNBC due to lack of viewership and credibility!), and Politico (The recipients of an illegal and ridiculous $8 Million Dollar subscription, an All Time Record, directly from the United States Government, under Crooked Joe Biden, in order to keep them "alive." Seems like corruption to me!), from the White House as a result of their constant "reporting" FAKE NEWS! Media Outlets shouldn't be able to constantly write or report FICTION and LIES when they're covering the President of the United States, the Trump Administration, or the United States of America. Other Fake News Media Outlets to follow. Thank you for your attention to this matter!"PHARMA DEALS WITH CHINA:The U.S. is working on rules for pharmaceutical companies investing in China that would likely preserve their ability to strike most licensing deals for Chinese drugs, Reuters' Michael Erman, citing three people familiar with the matter. That would mark a departure from the Trump administration's tightening of business with China for other industries under new national security legislation, and would be looser than restrictions sought by some lawmakers, the author notes. Publicly traded companies in the space include AstraZeneca, Bristol Myers, Eli Lilly, GSK, Johnson & Johnson, Merck, Novartis, Pfizer, Rocheand Sanofi.AI REGULATORY PLAN:MetaCEO Mark Zuckerberg, NvidiaCEO Jensen Huang, and Teslaand SpaceX'sElon Musk recently spoke with President Trump and successfully stalled an AI regulatory plan proposed by Demis Hassabis, The Wall Street Journal's Josh Dawsey and Amrith Ramkumar.