Zymeworks Inc

Zymeworks Inc (ZYME) Stock Analysis

$25.030

-0.701 (-2.80%)At close

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High
25.855
Open
25.670
VWAP
25.28
Volume
632.91K
Mkt Cap
594.63M
Low
24.940
Amount
16.00M
EV/EBITDA, TTM
-0.52

Zymeworks Inc. is a global biotechnology company building a diversified portfolio of healthcare assets. The Company's asset and royalty aggregation strategy combines a portfolio of commercial and near-commercial assets, including YUPELRI (revefenacin), with a differentiated internal research and development engine. The Company's portfolio also includes Ziihera (zanidatamab-hrii), a HER2-targeted bispecific antibody discovered and developed by it and commercialized through global partnerships with Jazz Pharmaceuticals and BeOne Medicines, and pasritamig, a clinical-stage multispecific antibody developed by Johnson & Johnson using the Company's proprietary antibody engineering technologies. The Company is advancing a diverse pipeline of novel biotherapeutics, leveraging its proprietary Azymetric platform and expertise in antibody-drug conjugates, multispecific antibodies and other next-generation antibody technologies. Its product candidates include ZW191, ZW251, ZW220, ZW209 and ZW1528.

AI analysis of Zymeworks Inc (ZYME)

Buy

Zymeworks Inc is a good buy right now due to its current price of $25.79, which is significantly lower than the average analyst price target of $39, suggesting an upside potential of approximately 51%. Additionally, the company's recent acquisition of Theravance Biopharma is expected to enhance its revenue streams, with projected 2026 revenue guidance between $278 million and $292 million. However, the main risk is the company's high debt-to-equity ratio of 314.34%, which indicates potential financial instability if not managed properly.

Analyst Ratings (4)

+42.03% upside
Buy
3 Buy
0 Hold
1 Sell
Current: 25.03
Low
30.00
Average
35.55
High
42.00

Truist

2026-10-07

Price Target

$34

Buy

Citi

2026-09-29

Price Target

$39

Buy

JPMorgan

2026-09-03

Price Target

$33

Overweight

H.C. Wainwright

2026-08-26

Price Target

$55

Buy

Citi

2026-08-26

Price Target

$38

Buy

Valuation Metrics

The current forward P/E ratio for Zymeworks Inc (ZYME) is 20.83, compared to its 5-year average forward P/E of 0.50.

Forward P/E

Fair
5Y Average P/E
0.50
Current P/E
20.83
Overvalued
22.96
Undervalued
-21.96

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
7.32
Current EV/EBITDA
-0.52
Overvalued
47.58
Undervalued
-32.95

Forward P/S

Fair
5Y Average P/S
8.16
Current P/S
4.54
Overvalued
12.64
Undervalued
3.68

Alphio AI Price Scenarios for ZYME

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%ZYME

$16.50

Scenario price

B

Base

Base · 50%ZYME

$15.02

Scenario price

B

Bear

Bear · 25%ZYME

$13.38

Scenario price

Whales holding ZYME

R

Rubric Capital Management LP

+ HoldingZYME

+0.02%

3M Return

E

EcoR1 Capital, LLC

+ HoldingZYME

-12.09%

3M Return

P

Perceptive Advisors LLC

+ HoldingZYME

-17.84%

3M Return

Events Timeline

2026-09-28 (ET)

16:30:00

Major Averages Decline as Oil Prices Come into Focus

13:30:00

Zymeworks Completes Acquisition of Theravance Biopharma

12:00:00

Major Averages Broadly Lower as Oil Prices Surge Over 3%

06:30:00

Zymeworks Acquisition Expected to Generate $25-30 Million Incremental Revenue

06:30:00

Zymeworks Updates Financial Guidance for 2026

News

ZYME FAQ — answered by Alphio AI

Zymeworks Inc. is a global biotechnology company building a diversified portfolio of healthcare assets. The Company's asset and royalty aggregation strategy combines a portfolio of commercial and near-commercial assets, including YUPELRI (revefenacin), with a differentiated internal research and development engine. The Company's portfolio also includes Ziihera (zanidatamab-hrii), a HER2-targeted bispecific antibody discovered and developed by it and commercialized through global partnerships with Jazz Pharmaceuticals and BeOne Medicines, and pasritamig, a clinical-stage multispecific antibody developed by Johnson & Johnson using the Company's proprietary antibody engineering technologies. The Company is advancing a diverse pipeline of novel biotherapeutics, leveraging its proprietary Azymetric platform and expertise in antibody-drug conjugates, multispecific antibodies and other next-generation antibody technologies. Its product candidates include ZW191, ZW251, ZW220, ZW209 and ZW1528. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Zymeworks Inc is a good buy right now due to its current price of $25.79, which is significantly lower than the average analyst price target of $39, suggesting an upside potential of approximately 51%. Additionally, the company's recent acquisition of Theravance Biopharma is expected to enhance its revenue streams, with projected 2026 revenue guidance between $278 million and $292 million. However, the main risk is the company's high debt-to-equity ratio of 314.34%, which indicates potential financial instability if not managed properly.

4 analysts cover ZYME: 3 rate it Buy, 0 Hold and 1 Sell. The average price target is 35.55.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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