Summit Therapeutics Inc

Summit Therapeutics Inc (SMMT) Stock Analysis

$15.570

+1.001 (+6.43%)At close

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High
15.770
Open
14.900
VWAP
15.39
Volume
6.15M
Mkt Cap
5.52B
Low
14.830
Amount
94.71M
EV/EBITDA, TTM
0.00

Summit Therapeutics Inc. is a biopharmaceutical company focused on the discovery, development, and commercialization of patient, physician, caregiver and societal-friendly medicinal therapies intended to improve quality of life, increase potential duration of life, and resolve serious unmet medical needs. Its lead development candidate is ivonescimab, a novel, potential first-in-class bispecific antibody intending to combine the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects of an anti-VEGF compound into a single molecule. Ivonescimab is being developed by both Akeso and the Company in multiple Phase III clinical trials. It is also developing ivonescimab in non-small cell lung cancer and other solid tumor settings. Ivonescimab is approved in China in combination with chemotherapy for patients with EGFR-mutated non-small cell lung cancer whose tumors have progressed following an EGFR-TKI based on the results of the HARMONi-A clinical trial.

AI analysis of Summit Therapeutics Inc (SMMT)

Hold

Summit Therapeutics Inc (SMMT) is currently priced at $14.63, which is significantly lower than the analyst price target of $43 from Citi, indicating potential upside. However, the RSI is at a low 25.011, suggesting the stock is oversold and may face further downward pressure in the short term. The company has experienced a 5-day change of -16.83% and a year-to-date change of -16.50%, indicating recent volatility and negative performance. The upcoming earnings report on October 19, 2026, could be a catalyst for movement, but the current financials show significant losses, with a projected EPS of -0.28. Given these factors, while there is potential for recovery, the risks associated with continued losses and market volatility suggest a hold position for now.

Analyst Ratings (6)

+172.90% upside
Buy
6 Buy
0 Hold
0 Sell
Current: 15.57
Low
18.00
Average
42.49
High
131.90

Barclays

2026-10-01

Price Target

$20

Equal Weight

Citi

2026-09-29

Price Target

$43

Buy

Jefferies

2026-09-09

Price Target

$25

Buy

Bernstein

2026-08-25

Price Target

—

Market Perform

Leerink

2026-08-12

Price Target

$13

Market Perform

Valuation Metrics

The current forward P/E ratio for Summit Therapeutics Inc (SMMT) is 3.72, compared to its 5-year average forward P/E of -20.36.

Forward P/E

Fair
5Y Average P/E
-20.36
Current P/E
3.72
Overvalued
7.40
Undervalued
-48.11

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-17.39
Current EV/EBITDA
0.00
Overvalued
4.58
Undervalued
-39.36

Forward P/S

Fair
5Y Average P/S
382.54
Current P/S
278.00
Overvalued
954.29
Undervalued
-189.22

Alphio AI Price Scenarios for SMMT

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%SMMT

$32.18

Scenario price

B

Base

Base · 50%SMMT

$28.61

Scenario price

B

Bear

Bear · 25%SMMT

$23.40

Scenario price

Whales holding SMMT

L

Logos Global Management, L.P.

+ HoldingSMMT

-12.15%

3M Return

Events Timeline

2026-10-19 (ET)

14:30:00

Summit Therapeutics Options Volume Normal, Implied Volatility at 4.1%

07:30:00

Summit Therapeutics Initiates Ivonescimab Clinical Trial

2026-10-05 (ET)

07:30:00

Summit Therapeutics Closes $2B Investment from AstraZeneca

2026-10-02 (ET)

06:00:00

Summit Therapeutics Partners with Daiichi Sankyo and AstraZeneca for Clinical Trial

2026-09-29 (ET)

09:00:00

Stock Futures Edge Higher as Tech Stocks Stabilize

News

SMMT FAQ — answered by Alphio AI

Summit Therapeutics Inc. is a biopharmaceutical company focused on the discovery, development, and commercialization of patient, physician, caregiver and societal-friendly medicinal therapies intended to improve quality of life, increase potential duration of life, and resolve serious unmet medical needs. Its lead development candidate is ivonescimab, a novel, potential first-in-class bispecific antibody intending to combine the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects of an anti-VEGF compound into a single molecule. Ivonescimab is being developed by both Akeso and the Company in multiple Phase III clinical trials. It is also developing ivonescimab in non-small cell lung cancer and other solid tumor settings. Ivonescimab is approved in China in combination with chemotherapy for patients with EGFR-mutated non-small cell lung cancer whose tumors have progressed following an EGFR-TKI based on the results of the HARMONi-A clinical trial. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Summit Therapeutics Inc (SMMT) is currently priced at $14.63, which is significantly lower than the analyst price target of $43 from Citi, indicating potential upside. However, the RSI is at a low 25.011, suggesting the stock is oversold and may face further downward pressure in the short term. The company has experienced a 5-day change of -16.83% and a year-to-date change of -16.50%, indicating recent volatility and negative performance. The upcoming earnings report on October 19, 2026, could be a catalyst for movement, but the current financials show significant losses, with a projected EPS of -0.28. Given these factors, while there is potential for recovery, the risks associated with continued losses and market volatility suggest a hold position for now.

6 analysts cover SMMT: 6 rate it Buy, 0 Hold and 0 Sell. The average price target is 42.49.

Community

More ↗
lunarviper10/5/2026

$SMMT just landed a major combo opportunity for ivonescimab — and Datroway is the key. Summit is teaming with AstraZeneca ($AZN) and Daiichi Sankyo to evaluate ivonescimab with Datroway, a TROP2-targeted ADC jointly developed and commercialized by Daiichi and AstraZeneca. The initial focus is a Phase III study in first-line TNBC, while the collaboration plans to evaluate the combo across multiple solid tumors, including breast and lung cancers. Latest SMMT news here

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0xLunarbazaar9/29/2026

$SMMT $AZN Citi raised its price target on Summit Therapeutics (SMMT) to $43 from $40 and keeps a Buy rating on the shares after the company announced a $2B investment from AstraZeneca (AZN). AstraZeneca's $2B investment in convertible preferred shares is equivalent to $18.36 per common share, representing a 19% premium to Summit's latest closing price, the analyst tells investors in a research note. Citi views the deal as a "de-risking event" that removes Summit's financing overhang.

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molten_vortex9/26/2026

Innovation Is Driving a New Bull Market in Biotech. 16 Ways to Play It, From Our Roundtable Experts. Biotechnology stocks are soaring this year as medical advances and merger activity rekindle investor interest. More gains lie ahead, our healthcare panel says. A tidal wave of innovation in biotechnology is improving patient outcomes, transforming the industry's prospects, and lifting long-suffering biotech shares. Spurred by therapeutic breakthroughs and new-product launches, investors have bid up the iShares Biotechnology, or IBB, by 24% this year, while the State Street SPDR S&P Biotech ETF, or XBI, has risen 28%, more than twice the gain of the S&P 500. Large pharmaceutical companies are also paying attention. They have been striking licensing deals with smaller biotechs and scooping up whole companies in a bid to rebuild their pipelines and replace blockbuster drugs facing patent expirations. $MRNA $MRK $RVMD $BMY $SMMT

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