Septerna Inc

Septerna Inc (SEPN) Stock Analysis

$36.350

-1.069 (-2.94%)At close

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High
37.470
Open
37.470
VWAP
36.30
Volume
234.14K
Mkt Cap
—
Low
35.090
Amount
8.50M
EV/EBITDA, TTM
-37.71

Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. It is advancing programs in endocrinology, immunology and inflammation, metabolic diseases and additional therapeutic areas, both independently and with partners. The Company's Native Complex Platform is designed to enable it to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with significant unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.

septerna.com

AI analysis of Septerna Inc (SEPN)

Hold

Currently, Septerna Inc is not a strong buy due to its recent price decline and mixed financial performance. The current price is $36.35, and the RSI is at 41.302, indicating it is nearing oversold territory but not yet a strong buy signal. The forward P/E ratio is notably high at 107.53, suggesting that the stock may be overvalued relative to its earnings potential. Additionally, the stock has seen a 5-day change of -5.26% and a 20-day change of -6.05%, reflecting recent downward momentum. The main risk is the high forward P/E ratio, which indicates potential overvaluation if future earnings do not meet expectations.

Valuation Metrics

The current forward P/E ratio for Septerna Inc (SEPN) is 107.53, compared to its 5-year average forward P/E of 31.83.

Forward P/E

Overvalued
5Y Average P/E
31.83
Current P/E
107.53
Overvalued
101.93
Undervalued
-38.28

Forward EV/EBITDA

Undervalued
5Y Average EV/EBITDA
-13.18
Current EV/EBITDA
-37.71
Overvalued
4.66
Undervalued
-31.01

Forward P/S

Fair
5Y Average P/S
89.93
Current P/S
23.74
Overvalued
328.09
Undervalued
-148.23

Whales holding SEPN

S

Sofinnova Investments, Inc.

+ HoldingSEPN

+7.79%

3M Return

A

ADAR1 Capital Management, LLC

+ HoldingSEPN

-16.51%

3M Return

R

RA Capital Management, L.P.

+ HoldingSEPN

-26.36%

3M Return

Events Timeline

2026-08-10 (ET)

16:30:00

Septerna Reports Q2 Revenue of $26.75M, Beating Consensus

2026-05-11 (ET)

16:10:00

Septerna Reports Q1 Revenue of $26.52M, Exceeding Expectations

2026-04-13 (ET)

08:10:00

Septerna Doses First Participants in SEP-479 Clinical Trial

2026-03-10 (ET)

16:40:00

Septerna Files Automatic Mixed Securities Shelf

2026-03-09 (ET)

16:40:00

Septerna Reports Q4 Revenue of $24.12M

News

SEPN FAQ — answered by Alphio AI

Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. It is advancing programs in endocrinology, immunology and inflammation, metabolic diseases and additional therapeutic areas, both independently and with partners. The Company's Native Complex Platform is designed to enable it to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with significant unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease. It operates in the Healthcare sector.

Currently, Septerna Inc is not a strong buy due to its recent price decline and mixed financial performance. The current price is $36.35, and the RSI is at 41.302, indicating it is nearing oversold territory but not yet a strong buy signal. The forward P/E ratio is notably high at 107.53, suggesting that the stock may be overvalued relative to its earnings potential. Additionally, the stock has seen a 5-day change of -5.26% and a 20-day change of -6.05%, reflecting recent downward momentum. The main risk is the high forward P/E ratio, which indicates potential overvaluation if future earnings do not meet expectations.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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