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Dow Rises 556.21 Points, Nasdaq Ends Little Changed
The Dow advanced and the Nasdaq finished little changed, but ended well off its worst levels, as concerns around overspending on AI led to underperformance in the tech-heavy index. Meanwhile, the producer price index rose 1.3% month over month, the largest increase since March 2022, following a 0.4% gain in August and exceeding economists' expectations for a 0.6% advance. On an annual basis, producer prices climbed 6.3%, up from 5.6% in August and the highest rate since December 2022.Get caught up quickly on the top news and calls moving stocks with these five Top Five lists.1. STOCK NEWS:Anthropic informed prospective investors that its Q3 revenue reached $16.8B, as the Claude maker forges ahead with plans for an IPO, Bloomberg reportsTSMCreported better-than-expected Q3 resultsPenske Automotiveagreed to be taken private in a $16.3B transactionCCC Intelligent Solutionsagreed to be acquired by GTCR and Elliott for $6.1BMetarolled out Muse Spark Open on AppleM5 Ultra Macs2. WALL STREET CALLS:Deutsche Bank upgraded Walmartto Buy on favorable 2027 setupSpotifydowngraded to Hold at StoneX on "tempered" gross margin viewQuantinuumupgraded to Overweight at Morgan StanleyPayPalreinstated at Underperform, down from Neutral, at BofACarMaxdouble upgraded to Buy from Underperform at BofA3. AROUND THE WEB:Appleclosed above a $5T market capitalization on Wednesday, ending the day at $5.005T, the second company after Nvidiato do so, WSJ reportsLone Star and Atlas Holdings are both exploring "multibillion-dollar bids" for International Paper'sEuropean packaging business, previously known as DS Smith, FT saysNvidia CEO Jensen Huang said the chipmaker "absolutely must" work with Chinese AI companies on monitoring risks, telling CNBC that AI is "potentially dangerous," and that he has ongoing "dialogues" with researchers in ChinaSpaceXhas restricted some Starlink services in Ukraine by disabling military-grade terminals traveling above 100 mph, Reuters reportsSignet Jewelersand Richemontare in talks to join the Global Diamond Consortium to buy diamond miner De Beers from Anglo American, Bloomberg says4. MOVERS:OPKO Healthgained after entering into an agreement for Labcorpto acquire select assets of OPKO Health subsidiary BioReference HealthEricssonincreased in New York after reporting Q3 results and announcing with Verizonthe completion of the first 6G field callRecursion Pharmaceuticalswas higher after reporting data from its REC-1245 and REC-4881 trials, announcing Sanofioptioned the first development candidate from their multi-program research collaboration, and pricing 61.54M shares of its stockCybersecurity companies including CrowdStrikeand Palo Alto Networkswere lower after Semafor reported that Perplexity is "giving away" its AI sandbox SPACEAquestive Therapeuticsfell after announcing the FDA acknowledged its resubmission of the NDA for Anaphylm sublingual film5. EARNINGS/GUIDANCE:FMCcut its Q3 revenue guidance, saying it is facing slower-than-expected demand from channel customers in key marketsPrologisreported Q3 results and raised its outlook for FY26, with CEO Daniel Letter saying the company "executed well" this quarter"ManpowerGroupreported Q3 results, with EPS in-line with consensusU.S. Bancorpreported Q3 results, provided guidance for Q4, and raised its outlook for FY26PNC Financialreported Q3 results with EPS beating consensusINDEXES:The Dow rose 556.21, or 1.08%, to 52,177.69, the Nasdaq gained 20.16, or 0.08%, to 26,713.03, and the S&P 500 advanced 25.12, or 0.33%, to 7,744.06.
Nasdaq Underperforms as Producer Price Index Rises 1.3% MoM
The major averages were mixed near noon as concerns around tech firms overspending on AI are mounting, leading to underperformance for the Nasdaq. Meanwhile, the producer price index rose 1.3% month over month, the largest increase since March 2022, following a 0.4% gain in August and exceeding economists' expectations for a 0.6% advance. On an annual basis, producer prices climbed 6.3%, up from 5.6% in August and the highest rate since December 2022.Get caught up quickly on the top news and calls moving stocks with these five Top Five lists.1. STOCK NEWS:Anthropic informed prospective investors that its Q3 revenue reached $16.8B, as the Claude maker forges ahead with plans for an IPO, Bloomberg reportsTSMCreported better-than-expected Q3 resultsPenske Automotiveagreed to be taken private in a $16.3B transactionCCC Intelligent Solutionsagreed to be acquired by GTCR and Elliott for $6.1BFMCcut its Q3 revenue guidance, saying it is facing slower-than-expected demand from channel customers in key markets2. WALL STREET CALLS:Deutsche Bank upgraded Walmartto Buy on favorable 2027 setupSpotifydowngraded to Hold at StoneX on "tempered" gross margin viewQuantinuumupgraded to Overweight at Morgan StanleyPayPalreinstated at Underperform, down from Neutral, at BofACarMaxdouble upgraded to Buy from Underperform at BofA3. AROUND THE WEB:Appleclosed above a $5T market capitalization on Wednesday, ending the day at $5.005T, the second company after Nvidiato do so, WSJ reportsLone Star and Atlas Holdings are both exploring "multibillion-dollar bids" for International Paper'sEuropean packaging business, previously known as DS Smith, FT saysNvidia CEO Jensen Huang said the chipmaker "absolutely must" work with Chinese AI companies on monitoring risks, telling CNBC that AI is "potentially dangerous," and that he has ongoing "dialogues" with researchers in ChinaSpaceXhas restricted some Starlink services in Ukraine by disabling military-grade terminals traveling above 100 mph, Reuters reportsSignet Jewelersand Richemontare in talks to join the Global Diamond Consortium to buy diamond miner De Beers from Anglo American, Bloomberg says4. MOVERS:OPKO Healthgains after entering into an agreement for Labcorpto acquire select assets of OPKO Health subsidiary BioReference HealthEricssonincreases in New York after reporting Q3 results and announcing with Verizonthe completion of the first 6G field callRecursion Pharmaceuticalshigher after reporting data from its REC-1245 and REC-4881 trials, announcing Sanofioptioned the first development candidate from their multi-program research collaboration, and pricing 61.54M shares of its stockRocket Lablower after delaying the Neutron launch to 2027Aquestive Therapeuticsfalls after announcing the FDA acknowledged its resubmission of the NDA for Anaphylm sublingual film5. EARNINGS/GUIDANCE:Prologisreported Q3 results and raised its outlook for FY26, with CEO Daniel Letter saying the company "executed well" this quarter"ManpowerGroupreported Q3 results, with EPS in-line with consensusVelo3Dreported preliminary results for Q3U.S. Bancorpreported Q3 results, provided guidance for Q4, and raised its outlook for FY26PNC Financialreported Q3 results with EPS beating consensusINDEXES:Near midday, the Dow was up 434.68, or 0.84%, to 52,056.16, the Nasdaq was down 102.50, or 0.38%, to 26,590.37, and the S&P 500 was up 4.71, or 0.06%, to 7,723.65.
Tech Stocks Decline, Nasdaq and S&P 500 Suffer Major Drops
Stock futures are pointing to a mixed open as a technology selloff deepens following hotter-than-expected inflation data and renewed concerns about the cost of financing the artificial-intelligence buildout. The Nasdaq and S&P 500 suffered their steepest daily declines in months Wednesday after September CPI came in above expectations, fueling concerns that the Federal Reserve may need to keep rates higher for longer or raise them again.AI-related stocks remain under pressure. Investors are increasingly questioning whether elevated borrowing costs and the scale of AI infrastructure spending could constrain future growth, even as demand for AI computing remains strong.The Producer Price Index rose 1.3% month over month, the largest increase since March 2022, following a 0.4% gain in August and exceeding economists' expectations for a 0.6% advance. On an annual basis, producer prices climbed 6.3%, up from 5.6% in August and the highest rate since December 2022. Core PPI, which excludes food and energy, rose 0.7% monthly and 5% annually, suggesting inflationary pressures are extending beyond volatile commodity prices.In pre-market trading, S&P 500 futures fell 0.32%, Nasdaq futures fell 1.31% and Dow futures rose 0.43%.Check out this morning's top movers from around Wall Street, compiled by The Fly.HIGHER -Opko Healthup 21% after agreeing to a deal for Labcorpto acquire select assets of BioReference Health for $722MPenske Automotiveup 8% after entering into a $16.3B merger agreement to be taken private by Motown Acquisition Corp., an entity owned by Penske Corporation and MitsuiUP AFTER EARNINGS -Ericssonup 11%Kimberly-Clarkup 3%BNY Mellonup 2%CMC Industriesup 2%Prologisup 1%Marsh McLennanup 1%DOWN AFTER EARNINGS -ManpowerGroupdown 12%First Horizondown 5%Charles Schwabdown 3%TSMCdown 3%PNC Financialdown 2%LOWER -FMCdown 39% after cutting third quarter guidance
Labcorp Acquires OPKO Subsidiary Assets for $722M
Labcorp (LH) and OPKO Health (OPK) have entered into an agreement for Labcorp to acquire select assets of BioReference Health, a wholly owned subsidiary of OPKO Health. Through this transaction, Labcorp will acquire BioReference Health's laboratory testing businesses focused on clinical and women's health testing services, urology, corrections and certain operational assets, including over 80 additional patient service centers. As part of the agreement, Labcorp will also acquire BioReference Health's proprietary 4Kscore Test, an FDA-approved blood test that helps predict the likelihood of finding aggressive prostate cancer before a biopsy decision. The purchase price for the transaction is $722M in cash at closing, subject to an upward or downward adjustment based on closing business revenues, and up to an additional $150M in an earnout based on revenue from the 4Kscore Test. Labcorp expects the business revenue to be approximately $250M in the first year after close, based on Labcorp's current post-closing forecasts. This transaction is subject to regulatory approvals and customary closing conditions. Until the transaction closes, there will be no changes to operations or services, and both companies will continue to operate independently.
Labcorp Holdings Reaffirms 2026-2029 Long-Term Outlook
In a regulatory filing, the company stated, "On September 21, 2026, the Centers for Medicare & Medicaid Services released preliminary Clinical Laboratory Fee Schedule payment rates applicable from 2027 through 2029 pursuant to the Protecting Access to Medicare Act. Labcorp Holdings believes the payment rates are based on data that is not fully representative of the broader commercial laboratory market and would impose steep annual payment cuts that threaten patient access to laboratory services. Therefore, the company continues to support the bipartisan Reforming and Enhancing Sustainable Updates to Laboratory Testing Services Act, a bipartisan solution that would ensure the U.S. has a sustainable and innovative laboratory system. The company previously considered the anticipated continuation of PAMA-related reimbursement pressure in developing the 2026-2029 long-term outlook announced at its Investor Day on September 10, 2026, and the company is now reaffirming that outlook, which is: Compound annual revenue growth between 5% and 8%; Adjusted operating margin expansion between 75 and 150 basis points by the end of 2029; Compound annual adjusted EPS growth between 8.5% and 11.5%; Compound annual free cash flow growth in line with adjusted earnings growth. The company is continuing to evaluate the CMS payment rates and expects to provide additional information regarding the impact of the CMS payment rates on its 2027 financial guidance when that guidance is announced in February 2027. Other than the 2026-2029 long-term outlook referenced above, all of the information included in the company's September 10, 2026, Investor Day presentation is presented as of the dates indicated."
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