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Parabilis Medicines Updates Safety and Efficacy Data for Zolucatetide
Parabilis Medicines announced updated safety and efficacy data for zolucatetide, the first and only direct inhibitor of the beta-catenin:TCF interaction, in patients with desmoid tumors. The data were presented today in an oral presentation at the European Society for Medical Oncology, ESMO, Congress 2026, taking place October 23-27, 2026, in Madrid, Spain. The updated results, based on a June 22, 2026, data cutoff, include data from both the dose escalation and dose optimization portions of the ongoing Phase 1/2 trial and reinforce the strong efficacy and favorable safety and tolerability profile observed with zolucatetide. Among response-evaluable patients who began treatment at a starting dose of greater than or equal to 450 mg, zolucatetide demonstrated an objective response rate, ORR, of 72.2% in a 32-week landmark analysis. A disease control rate, DCR, of 100% was observed across all 46 response-evaluable patients who received a starting dose of greater than or equal to450 mg, with no disease progression.
Parabilis Medicines Stock Rises 6.3% to $29.20
Parabilis Medicines is up 6.3%, or $1.72 to $29.20.
Parabilis Medicines Shares Drop 12.5% to $36.51
Parabilis Medicines is down -12.5%, or -$5.22 to $36.51.
Parabilis Medicines Appoints Craig Tendler to Board of Directors
Parabilis Medicines announced the appointment of Craig Tendler to its board of directors. Tendler has served as a scientific advisor to Parabilis Medicines, a role he will continue alongside his board responsibilities. Tendler brings more than 30 years of experience in oncology drug development and medical affairs, including two decades at Johnson & Johnson, where he most recently served as global head of late-stage clinical development and global medical affairs for oncology. Tendler currently serves on the board of directors of TuHURA Biosciences and Predicta Biosciences and as a scientific advisor for several biotechnology companies. He is also an alternate industry representative to the FDA's Oncologic Drugs Advisory Committee.
Parabilis Medicines Q2 Revenue $148K, Misses Consensus $16.67M
Reports Q2 revenue $148,000, consensus $16.67M. "This quarter marked meaningful progress toward our long-term vision as we continued advancing zolucatetide across multiple Wnt/beta-catenin-driven diseases, including toward planned registrational development in desmoid tumors, while also extending the reach of our Helicon(TM) platform through our strategic research collaboration with Regeneron focused on developing Antibody-Helicon Conjugates," said Mathai Mammen, M.D., Ph.D., Chairman, President and Chief Executive Officer of Parabilis Medicines.
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