Protagonist Therapeutics Inc

Protagonist Therapeutics Inc (PTGX) Stock Analysis

$144.330

-4.994 (-3.46%)At close

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High
147.950
Open
147.730
VWAP
144.90
Vol
501.25K
Mkt Cap
1.87B
Low
142.430
Amount
72.63M
EV/EBITDA, TTM
61.44

Protagonist Therapeutics, Inc. is a biopharmaceutical company with a technology platform that enables de novo discovery of peptide therapeutics. The Company's programs fall into three therapeutic areas: inflammation and immunology (I&I), hematology, and metabolic diseases. Its clinical and pre-clinical programs address biologically and commercially validated targets, including IL-17 oral peptide antagonist PN-881, obesity triple agonist peptide PN-477, obesity dual agonist peptide PN-458, oral small molecule hepcidin functional mimetic PN-8047, and IL-4 and amylin programs. The ICOTYDE (icotrokinra) is used for the treatment of moderate-to-severe plaque psoriasis in adults and pediatric patients 12 years of age or older who weigh at least 40 kg and are candidates for systemic therapy or phototherapy. Rusfertide is an investigational injectable mimetic of the natural hormone hepcidin in development for the treatment of the rare blood disorder polycythemia vera (PV).

AI analysis of Protagonist Therapeutics Inc (PTGX)

buy

Protagonist Therapeutics Inc (PTGX) is a good buy right now due to its recent strong earnings report, which showed a Non-GAAP EPS of $2.29, exceeding expectations by $0.36, and a staggering revenue growth of 3746.5% year-over-year, reaching $213.48 million. However, the stock has a current RSI of 29.935, indicating it is oversold, which presents a buying opportunity. The main risk is the recent insider selling, which has increased by 7175.14% over the last month, suggesting potential concerns among insiders about the stock's future performance.

Analyst Ratings (4)

-34.50% downside
Buy
4 Buy
0 Hold
0 Sell
Current: 144.33
Low
65.00
Average
94.54
High
115.00

Truist

2026-08-10

Price Target

$170

Buy

Wedbush

2026-08-10

Price Target

$173

Outperform

Goldman Sachs

2026-08-10

Price Target

$186

Buy

Clear Street

2026-08-06

Price Target

$173

Buy

Citi

2026-08-06

Price Target

$175

Buy

Valuation Metrics

The current forward P/E ratio for Protagonist Therapeutics Inc (PTGX) is 37.74, compared to its 5-year average forward P/E of -13.43.

Forward P/E

Overvalued
5Y Average P/E
-13.43
Current P/E
37.74
Overvalued
37.56
Undervalued
-64.42

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-15.50
Current EV/EBITDA
61.44
Overvalued
195.72
Undervalued
-226.73

Forward P/S

Fair
5Y Average P/S
36.32
Current P/S
47.80
Overvalued
58.24
Undervalued
14.39

Alphio AI Price Scenarios for PTGX

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%PTGX

$69.30

Scenario price

B

Base

Base · 50%PTGX

$55.78

Scenario price

B

Bear

Bear · 25%PTGX

$40.24

Scenario price

Whales holding PTGX

A

Affinity Asset Advisors, LLC

+ HoldingPTGX

+14.65%

3M Return

D

Duquesne Family Office LLC

+ HoldingPTGX

+9.41%

3M Return

P

Perceptive Advisors LLC

+ HoldingPTGXPRAX

+4.39%

3M Return

A

ADAR1 Capital Management, LLC

+ HoldingPTGXRVMD

+2.25%

3M Return

W

Woodline Partners LP

+ HoldingPTGX

+2.02%

3M Return

H

Hood River Capital Management LLC

+ HoldingPTGX

-12.53%

3M Return

Events Timeline

2026-08-30 (ET)

17:00:00

Protagonist Partners with Takeda to Launch MIMRYLO

2026-08-05 (ET)

20:00:00

Protagonist Reports Q2 Revenue of $213.48M, Below Consensus

2026-05-05 (ET)

17:50:00

Protagonist Reports Q1 Revenue of $56.37M, Exceeding Expectations

2026-04-28 (ET)

09:40:00

Protagonist Therapeutics Exercises Opt-Out Right for $400 Million

News

PTGX FAQ — answered by Alphio AI

Protagonist Therapeutics, Inc. is a biopharmaceutical company with a technology platform that enables de novo discovery of peptide therapeutics. The Company's programs fall into three therapeutic areas: inflammation and immunology (I&I), hematology, and metabolic diseases. Its clinical and pre-clinical programs address biologically and commercially validated targets, including IL-17 oral peptide antagonist PN-881, obesity triple agonist peptide PN-477, obesity dual agonist peptide PN-458, oral small molecule hepcidin functional mimetic PN-8047, and IL-4 and amylin programs. The ICOTYDE (icotrokinra) is used for the treatment of moderate-to-severe plaque psoriasis in adults and pediatric patients 12 years of age or older who weigh at least 40 kg and are candidates for systemic therapy or phototherapy. Rusfertide is an investigational injectable mimetic of the natural hormone hepcidin in development for the treatment of the rare blood disorder polycythemia vera (PV). It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Protagonist Therapeutics Inc (PTGX) is a good buy right now due to its recent strong earnings report, which showed a Non-GAAP EPS of $2.29, exceeding expectations by $0.36, and a staggering revenue growth of 3746.5% year-over-year, reaching $213.48 million. However, the stock has a current RSI of 29.935, indicating it is oversold, which presents a buying opportunity. The main risk is the recent insider selling, which has increased by 7175.14% over the last month, suggesting potential concerns among insiders about the stock's future performance.

4 analysts cover PTGX: 4 rate it Buy, 0 Hold and 0 Sell. The average price target is 94.54.

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