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Johnson & Johnson Launches Shockwave C2 Aero Coronary Catheter
Johnson & Johnson announced the U.S. launch of its Shockwave C2 Aero Fly Coronary IVL Catheter designed to treat a broad range of calcified coronary artery lesions in half the time as previous coronary IVL devices. Leveraging Shockwave IVL's differentiated mechanism of action, and building on improvements delivered in the Shockwave C2 Aero platform, this next-generation coronary IVL catheter delivers pulses at double the speed and decreases pause time between pulsing cycles by half, while maintaining the safety and effectiveness of prior-generation catheters.
Johnson & Johnson Reports One-Year Results for TREMFYA
Johnson & Johnson announced one-year results from the Phase 3 FUZION study showing TREMFYA, or guselkumab, maintained or improved fistula remission through 48 weeks in adults with Crohn's disease, or CD. The findings build on the previously reported Week 24 results and further support the use of TREMFYA in one of the most difficult-to-treat manifestations of CD 2. The late-breaking findings are being presented at the 2026 United European Gastroenterology Week. Combined fistula remissiona, which incorporates both clinical and radiologic assessment, was maintained or improved in both TREMFYA maintenance regimens through Week 48. Among patients receiving TREMFYA 100 mg every 8 weeks (q8w), combined fistula remission further increased from 28% at Week 24 to 35% at Week 48. Similar findings were observed for rates of clinically assessed fistula remission. Results among patients receiving TREMFYA 200 mg every 4 weeks (q4w) remained consistent through Week 48. More than 90% of all randomized patients, which included both bio-naive and bio-experienced patients, completed treatment through Week 48. Safety findings through Week 48 were consistent with the well-established safety profile of TREMFYA in Crohn's disease. The 48-week findings reinforce the previously shared Week 24 results from FUZION, which showed that in the overall study population at Week 24, 28% of patients receiving TREMFYA 100 mg q8w and 27% receiving TREMFYA 200 mg q4w achieved combined fistula remission compared with 10% receiving placebo, making TREMFYA the only IL-23 inhibitor to demonstrate efficacy in a dedicated, randomized, placebo-controlled trial in patients with Crohn's disease with perianal fistula.
10-Year Treasury Yield Falls Below 5.2%, Financial Stocks Under Pressure
The yield on the 10-year Treasury note slipped below 5.2% for the first time in nearly two weeks on Tuesday, and yet sentiment in equities remained cautious, with little support from large financials ringing in the start of the Q3 earnings season.Energy was the best-performing sector in the S&P 500 as WTI crude oil gained for the fourth consecutive session, rising above $94 per barrel amid escalating conflict between Saudi Arabia and Yemeni Houthis. Healthcare was the worst-performing sector in the benchmark index, dragged down by disappointing Q3 results out of Johnson & Johnson. Financials were also under pressure, with shares of JPMorganending the day down nearly 1% after a rare earnings miss. Citiand Wells Fargofared worse, dropping 5.6% and 3.1% on earnings. In Tech, Semiconductor Equipment names were dragged down by a disappointing investor day presentation by Applied Materials, which shed 7% on the day, though Semiconductors - with the exception of more losses by Micron- largely held steady.In the opening hour of the evening session, S&P e-minis are a little changed while the Nasdaq 100 contract is down by 0.1%. Precious metals are holding steady, though the U.S. Dollar has pared some of its recent gains ahead of Wednesday's key CPI data.Check out this evening's top movers from around Wall Street, compiled by The Fly.HIGHER AFTER EARNINGS -AZZ Inc.up 1.8%ALSO HIGHER -Liquidiaup 46.1% after settlement agreement with United TherapeuticsGameStopup 2.2% after insider buyLOWER -Biomea Fusiondown 31.5% after announcing Phase 1 GLP-131 clinical trial results for BMF-650Tarsus Pharmaceuticalsdown 2.7% after registering stock for holdersBank of Americadown 2.1% after disclosing $1.2B fine from the Treasury Department due to money laundering allegations
S&P 500 Earnings Expected to Grow 30% in Q3
Stocks had a flattish session as investors digested earnings reports from big banks, as well as other major names like UnitedHealth and Domino's Pizza. Analysts expect S&P 500 earnings to grow 30% year-over-year in the third quarter, according to LSEG data. Meanwhile, Federal Reserve Bank of New York President John Williams told Bloomberg in an interview that it "may be appropriate to have one more rate hike."Get caught up quickly on the top news and calls moving stocks with these five Top Five lists.1. STOCK NEWS:Big banks kicked off earnings season, with Citiand Goldman Sachsposting upbeat results, Wells Fargoreporting mixed quarterly results, and JPMorganreporting lower-than-expected Q3 earnings and revenueUnitedHealthprovided a "beat and raise" report for Q3Johnson & Johnsonalso provided a "beat and raise" report for Q3Domino's Pizzareported better-than-expected Q3 earnings and revenueAppleintroduced the Apple Home Collection lineup of smart home accessories, as well as a new 4K Apple TV and Apple HomeView2. WALL STREET CALLS:VF Corp.upgraded to Buy at Truist and to Overweight at Piper SandlerPershing Square Inc.downgraded to Underperform from Neutral at BofAViking Holdingsupgraded to Overweight at BarclaysSecuritizedowngraded to Neutral at CitiAdobedowngraded to Hold at HSBC3. AROUND THE WEB:Boeingis set to begin deliveries of 737 Max aircraft to Japan's All Nippon Airways in December, Nikkei Asia reportsTake-Two'sRockstar intends to release a PC version of "Grand Theft Auto VI" during the first quarter of 2027, GamesBeat reportsTencenttold investors its planned bond offering of $5B will finance AI-related expenditures, Bloomberg saysKrogeranticipates a reduction of over one-third of its corporate headcount, eliminating about 3,000 roles across various functions over the next 3 years, Bloomberg reportsEpic Games has postponed the release of an upcoming video game collaboration with Disneyand has told its developers to use more AI tools to complete the game, Bloomberg says4. MOVERS:Bumblegained after announcing it will be acquired by Ithaca for $6.05 per share in cashFermirose after signing a credit support agreement with AMDBigBear.aiwas higher after securing more than $225M in contract awardsSyndaxwas lower after announcing its idiopathic pulmonary fibrosis study did not meet its endpointSix Flagsfell after one park visitor died and four others were injured at Six Flags Over Georgia5. EARNINGS/GUIDANCE:Unity Bancorpreported Q3 results, with CEO James Hughes calling it "another strong quarter"FB Financialreported Q3 results, with EPS in-line with consensusBeam Globalreported preliminary Q3 resultsScienturereported preliminary Q3 results, with revenue missing consensusAlbertsonsreported Q2 results, with CEO Susan Morris stating the results "do not reflect the potential of the Company"INDEXES:The Dow fell 180.45, or 0.35%, to 51,670.10, the Nasdaq lost 41.52, or 0.15%, to 27,204.38, and the S&P 500 declined 1.79, or 0.02%, to 7,805.45.
S&P 500 Earnings Expected to Grow 30% in Q3
The major averages were fractionally lower near noon as investors digest earnings reports from big banks, as well as other major names like UnitedHealth and Domino's Pizza. Analysts expect S&P 500 earnings to grow 30% year-over-year in the third quarter, according to LSEG data.Technology stocks are weighing on sentiment as concerns about Chinese competition intensify following reports of advances by chipmaker ChangXin Memory Technologies. Semiconductor shares are under pressure globally, with South Korea's Kospi dropping 5.5% and Japan's Nikkei falling 1.8%.Get caught up quickly on the top news and calls moving stocks with these five Top Five lists.1. STOCK NEWS:Big banks kicked off earnings season, with Citiand Goldman Sachsposting upbeat results, Wells Fargoreporting mixed quarterly results, and JPMorganreporting lower-than-expected Q3 earnings and revenueUnitedHealthprovided a "beat and raise" report for Q3Johnson & Johnsonalso provided a "beat and raise" report for Q3Domino's Pizzareported better-than-expected Q3 earnings and revenueAppleintroduced the Apple Home Collection lineup of smart home accessories, as well as a new 4K Apple TV and Apple HomeView2. WALL STREET CALLS:VF Corp.upgraded to Buy at Truist and to Overweight at Piper SandlerPershing Square Inc.downgraded to Underperform from Neutral at BofAViking Holdingsupgraded to Overweight at BarclaysSecuritizedowngraded to Neutral at CitiAdobedowngraded to Hold at HSBC3. AROUND THE WEB:TSMCexecutives in charge of overseas operations met Texas officials and started more serious discussions in 1H26, after talking on and off for more than 10 years, Culpium saysTencenttold investors its planned bond offering of $5B will finance AI-related expenditures, Bloomberg saysKrogeranticipates a reduction of over one-third of its corporate headcount, eliminating about 3,000 roles across various functions over the next 3 years, Bloomberg reportsEpic Games has postponed the release of an upcoming video game collaboration with Disneyand has told its developers to use more AI tools to complete the game, Bloomberg saysSpeaking at the DBS Asia Future Forward Conference in Singapore, BroadcomCEO Hock Tan cautioned that market sentiment has grown overheated and that short-term trading driven by volatile data resembles gambling, CNBC reports4. MOVERS:Bumblegains after announcing it will be acquired by Ithaca for $6.05 per share in cashFermirises after signing a credit support agreement with AMDBigBear.aihigher after securing more than $225M in contract awardsSyndaxlower after announcing its idiopathic pulmonary fibrosis study did not meet its endpointSix Flagsfalls after one park visitor died and four others were injured at Six Flags Over Georgia5. EARNINGS/GUIDANCE:Unity Bancorpreported Q3 results, with CEO James Hughes calling it "another strong quarter"FB Financialreported Q3 results, with EPS in-line with consensusBeam Globalreported preliminary Q3 resultsScienturereported preliminary Q3 results, with revenue missing consensusAlbertsonsreported Q2 results, with CEO Susan Morris stating the results "do not reflect the potential of the Company"INDEXES:Near midday, the Dow was down 141.31, or 0.27%, to 51,709.24, the Nasdaq was down 69.46, or 0.25%, to 27,176.44, and the S&P 500 was down 14.53, or 0.19%, to 7,792.71.
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