Alnylam Pharmaceuticals, Inc.

Alnylam Pharmaceuticals, Inc. (ALNY) Stock Analysis

$237.100

+0.545 (+0.23%)At close

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High
239.080
Open
224.465
VWAP
233.26
Vol
1.85M
Mkt Cap
31.24B
Low
223.610
Amount
430.87M
EV/EBITDA, TTM
24.02

Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults ; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Zilebesiran, Elebsiran, Mivelsiran, ALN-6400, and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.

AI analysis of Alnylam Pharmaceuticals, Inc. (ALNY)

hold

Alnylam Pharmaceuticals Inc is currently a hold. The stock is trading at $237.10, which is above the Fibonacci Pivot level of $233.68, indicating some short-term support. However, the stock has seen a significant decline of 40.75% year-to-date and 46.96% over the past year, raising concerns about its stability. The RSI is at 54.77, suggesting it is neither overbought nor oversold, which aligns with a cautious approach. The forward P/E ratio is 27.55, indicating that the stock is relatively expensive compared to its expected earnings growth. Analyst ratings vary, with a price target range from $230 to $455, showing mixed sentiment. The main risk is the recent negative trial results impacting its ATTR drug business, which could further pressure the stock.

Analyst Ratings (18)

+102.25% upside
Buy
13 Buy
4 Hold
1 Sell
Current: 237.10
Low
351.00
Average
479.53
High
580.00

Jefferies

2026-08-28

Price Target

$230

Hold

H.C. Wainwright

2026-08-04

Price Target

$455

Buy

Truist

2026-08-04

Price Target

$315

Buy

Raymond James

2026-08-03

Price Target

$420

Strong Buy

Citi

2026-08-03

Price Target

$340

Buy

Valuation Metrics

The current forward P/E ratio for Alnylam Pharmaceuticals, Inc. (ALNY) is 27.55, compared to its 5-year average forward P/E of -35.03.

Forward P/E

Fair
5Y Average P/E
-35.03
Current P/E
27.55
Overvalued
41.37
Undervalued
-111.43

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-7399.13
Current EV/EBITDA
24.02
Overvalued
51044.02
Undervalued
-65842.28

Forward P/S

Undervalued
5Y Average P/S
13.35
Current P/S
4.56
Overvalued
17.85
Undervalued
8.85

Alphio AI Price Scenarios for ALNY

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%ALNY

$422.33

Scenario price

B

Base

Base · 50%ALNY

$289.06

Scenario price

B

Bear

Bear · 25%ALNY

$182.69

Scenario price

Whales holding ALNY

W

Wanjia Asset Management Co., Ltd.

+ HoldingALNY

+25.24%

3M Return

R

Rock Springs Capital Management LP

+ HoldingALNY

+18.51%

3M Return

T

Tremblant Capital Group

+ HoldingALNY

+6.35%

3M Return

D

Deutsche Bank Aktiengesellschaft

+ HoldingALNY

+2.97%

3M Return

T

Tremblant Advisors LP

+ HoldingALNY

+2.37%

3M Return

L

Los Angeles Capital Management LLC

+ HoldingALNY

-1.04%

3M Return

ALNY FAQ — answered by Alphio AI

Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults ; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Zilebesiran, Elebsiran, Mivelsiran, ALN-6400, and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Alnylam Pharmaceuticals Inc is currently a hold. The stock is trading at $237.10, which is above the Fibonacci Pivot level of $233.68, indicating some short-term support. However, the stock has seen a significant decline of 40.75% year-to-date and 46.96% over the past year, raising concerns about its stability. The RSI is at 54.77, suggesting it is neither overbought nor oversold, which aligns with a cautious approach. The forward P/E ratio is 27.55, indicating that the stock is relatively expensive compared to its expected earnings growth. Analyst ratings vary, with a price target range from $230 to $455, showing mixed sentiment. The main risk is the recent negative trial results impacting its ATTR drug business, which could further pressure the stock.

18 analysts cover ALNY: 13 rate it Buy, 4 Hold and 1 Sell. The average price target is 479.53.

本頁僅供研究參考,不構成投資建議。模型可能出錯。過往表現不代表未來結果。

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