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PHVS 资讯
PHVS 事件
Pharvaris Publishes RAPIDe-3 Study Results Showing Efficacy of Deucrictibant IR for HAE Treatment
Pharvaris announced that results of RAPIDe-3, a phase 3 crossover study evaluating oral deucrictibant immediate-release capsule for the on-demand treatment of hereditary angioedema - HAE - attacks in adolescents and adults have been published in The Lancet. Results demonstrate that deucrictibant IR rapidly ended attack progression and accelerated the time to complete symptom resolution. RAPIDe-3 met its primary endpoint and all 11 secondary endpoints with high statistical significance. Deucrictibant IR achieved End of Progression of attack symptoms, symptom relief, and complete symptom resolution significantly faster than placebo. Deucrictibant IR was well tolerated with no safety signals observed. Results were consistent across subgroups of participants. Results of RAPIDe-3 are consistent with results of RAPIDe-1, published in April in The Lancet Haematology. RAPIDe-is ongoing. An expanded access program for deucrictibant IR for the on-demand treatment of HAE attacks is also available to people in U.S. meeting eligibility requirements. A New Drug Application for deucrictibant IR for the on-demand treatment of HAE attacks is currently under review with the FDA with a PDUFA target action date of April 23, 2027. A Marketing Authorization Application for deucrictibant IR for on-demand treatment of HAE attacks is also currently under review with the European Medicines Agency.
Dow Jones Drops Nearly 600 Points as Oil Prices Surge Raises Inflation Concerns
The major averages closed broadly lower, with the Dow Jones losing nearly 600 points as a renewed jump in oil prices and escalating Middle East tensions stoked inflation concerns.The rise in oil prices is particularly problematic coming after Friday's stronger-than-expected August jobs report. The U.S. added 162,000 jobs, nearly three times economists' expectations, pushing markets to increase bets that the Federal Reserve could raise rates at its September 16 meeting. The probability of a hike is now around 60%, while the 10-year Treasury yield has climbed to roughly 4.8%.Get caught up quickly on the top news and calls moving stocks with these five Top Five lists.1. STOCK NEWS:An Amazoncargo plane overshot the runway at Miami International Airport this weekend,Qualcommannounced awith AmazonGE AerospaceConsolidated Precision Products for $11.75BBoston Scientificsaid it isits Q3 and FY26 net sales and adjusted earnings per share guidanceNovartisshares fell after its Phase 3 HARBOR study for DM12. WALL STREET CALLS:Intelto Outperform at Northland after "material" turnaround progressPelotonto Underweight at Morgan StanleyAirbnbto Outperform at Raymond JamesBest Buyto Neutral at DA DavidsonSpaceXwith a Buy at Pivotal Research3. AROUND THE WEB:Netflixplans to report box office grosses for six upcoming films, Variety reportsNvidia-backedFirmus signed a multi-year deal with OpenAI to supply computing capacity to two Malaysian data centers, Reuters reportsAhead of Oura's upcoming IPO filing, Robinhoodhas been listed as an underwriter, WSJ saysNovo Nordiskhas halted two trials testing of ziltivekimab, its experimental heart disease medicine, would help patients with heart failure, Bloomberg reportsThe Independent Communications Authority of South Africa, South Africa's telecommunications regulator, plans to investigate prices charged by providers such as Netflixand Meta'sWhatsApp, Bloomberg reports4. MOVERS:Roivant Sciencesgained in New York after announcing its Phase 3 PHocus clinical trialPharvarisincreased in New York after announcing its CHAPTER-3 Phase 3 studyD-Wave Quantumwas higher afterwith the U.S. Department of CommerceSigma Lithiumfell after a preliminary judicial rulingBeam Therapeuticswas lower after announcing updated clinical data from its5. EARNINGS/GUIDANCE:United Natural Foodsand provided guidance for FY27ABMand raised its outlook for FY26, with CEO Scott Salmirs highlighting "record quarterly revenue, robust EPS growth and substantial cash generation"Solaris Energyraised itsGeneral Millsreaffirmed itsGameStop, with EPS higher year-over-yearINDEXES:The Dow fell 628.18, or 1.18%, to 52,786.07, the Nasdaq lost 85.58, or 0.32%, to 26,421.41, and the S&P 500 declined 45.08, or 0.58%, to 7,673.52.
Dow Jones Drops Over 500 Points as Oil Prices Rise Reviving Inflation Concerns
The major averages were broadly lower near noon, with the Dow Jones losing over 500 points as a renewed jump in oil prices and escalating Middle East tensions revive inflation concerns.The rise in oil prices is particularly problematic coming after Friday's stronger-than-expected August jobs report. The U.S. added 162,000 jobs, nearly three times economists' expectations, pushing markets to increase bets that the Federal Reserve could raise rates at its September 16 meeting. The probability of a hike is now around 60%, while the 10-year Treasury yield has climbed to roughly 4.8%.Get caught up quickly on the top news and calls moving stocks with these five Top Five lists.1. STOCK NEWS:An Amazoncargo plane overshot the runway at Miami International Airport this weekend,Qualcommannounced awith AmazonGE AerospaceConsolidated Precision Products for $11.75BBoston Scientificsaid it isits Q3 and FY26 net sales and adjusted earnings per share guidanceNovartisshares fell after its Phase 3 HARBOR study for DM12. WALL STREET CALLS:Intelto Outperform at Northland after "material" turnaround progressPelotonto Underweight at Morgan StanleyAirbnbto Outperform at Raymond JamesBest Buyto Neutral at DA DavidsonSpaceXwith a Buy at Pivotal Research3. AROUND THE WEB:Nvidia-backedFirmus signed a multi-year deal with OpenAI to supply computing capacity to two Malaysian data centers, Reuters reportsAhead of Oura's upcoming IPO filing, Robinhoodhas been listed as an underwriter, WSJ saysNovo Nordiskhas halted two trials testing of ziltivekimab, its experimental heart disease medicine, would help patients with heart failure, Bloomberg reportsAir Cairo is set to purchase 15 AirbusA320 family jets, with the deal expected to be finalized as soon as this week, Bloomberg saysThe Independent Communications Authority of South Africa, South Africa's telecommunications regulator, plans to investigate prices charged by providers such as Netflixand Meta'sWhatsApp, Bloomberg reports4. MOVERS:Roivant Sciencesgains in New York after announcing its Phase 3 PHocus clinical trialPharvarisincreases in New York after announcing its CHAPTER-3 Phase 3 studyD-Wave Quantumhigher afterwith the U.S. Department of CommerceSigma Lithiumfalls after a preliminary judicial rulingBeam Therapeuticslower after announcingfrom its Phase 1/2 trial evaluating BEAM-3025. EARNINGS/GUIDANCE:United Natural Foodsand provided guidance for FY27ABMand raised its outlook for FY26, with CEO Scott Salmirs highlighting "record quarterly revenue, robust EPS growth and substantial cash generation"Solaris Energyfor Q3 and Q4General Millsfor FY27GameStop, with EPS higher year-over-yearINDEXES:Near midday, the Dow was down 562.84, or 1.05%, to 52,851.41, the Nasdaq was down 23.20, or 0.09%, to 26,483.79, and the S&P 500 was down 27.48, or 0.36%, to 7,691.12.
Pharvaris Stock Rises 16.7% to $41.15
Pharvaris is up 16.7%, or $5.90 to $41.15.
Oil Price Surge Revives Inflation Concerns, S&P 500 Set for Weaker Open
The S&P is pointed toward a weaker open as a renewed jump in oil prices and escalating Middle East tensions revive inflation concerns. Brent crude has climbed to about $99 a barrel, while WTI is above $93, as attacks on energy infrastructure in the region raise concerns about further supply disruptions.The oil move is particularly problematic coming after Friday's stronger-than-expected August jobs report. The U.S. added 162,000 jobs, nearly three times economists' expectations, pushing markets to increase bets that the Federal Reserve could raise rates at its September 16 meeting. The probability of a hike is now around 60%, while the 10-year Treasury yield has climbed to roughly 4.8%.The market's attention now shifts to this week's inflation data, with PPI due Thursday and CPI Friday. Hot inflation readings could reinforce expectations for a September hike and put additional pressure on equities, while cooler-than-expected inflation would give the Fed more room to leave rates unchanged despite the strong labor market.In pre-market trading, S&P 500 futures fell 0.16%, Nasdaq futures rose 0.16% and Dow futures fell 0.66%.Check out this morning's top movers from around Wall Street, compiled by The Fly.HIGHER -Roivant Sciencesup 19% after reporting its PHocus clinical trial evaluating mosliciguat for the treatment of pulmonary hypertension associated with interstitial lung disease met primary and secondary endpointsPharavisup 19% after announcing that the primary endpoint and all secondary efficacy endpoints were met in the CHAPTER-3 study evaluating deucrictibant extended-release tablet for the prevention of hereditary angioedema attacksRigetti Computingup 7% after signing a definitive agreement with the U.S. Department of Commerce for an award of $100M in funding to accelerate superconducting quantum computing R&DHerbalifeup 5% after authorizing the repurchase of up to $250M in sharesLOWER -Novartisdown 12% after reporting that the global Phase 3 HARBOR study evaluating del-desiran in people living with myotonic dystrophy type 1 did not demonstrate statistically significant improvement versus placebo on the primary endpoint of video hand opening timeSigma Lithiumdown 11% after a preliminary judicial ruling suspending its environmental licensesPelotondown 5% after Morgan Stanley downgraded the stock to Underweight with a price target of $4.50, down from $5Boston Scientificdown 1% after saying it is unlikely to meet EPS and sales guidance following a cybersecurity incident that resulted in a global disruption to the company's operations
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