Xenon Pharmaceuticals Inc

Xenon Pharmaceuticals Inc (XENE) Stock Analysis

$59.990

-1.878 (-3.13%)At close

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High
61.620
Open
61.310
VWAP
60.47
Vol
587.93K
Mkt Cap
2.82B
Low
59.810
Amount
35.55M
EV/EBITDA, TTM
0.00

Xenon Pharmaceuticals Inc. is a Canada-based neuroscience-focused biopharmaceutical company committed to discovering, developing, and commercializing therapeutics to improve the lives of people living with neurological and psychiatric disorders. The Company is advancing a novel product pipeline to address areas of high unmet medical need, including epilepsy and depression. Azetukalner, a novel, highly potent, selective Kv7 potassium channel opener, represents the advanced, clinically validated potassium channel modulator in late-stage clinical development for the treatment of multiple indications that include epilepsy, including focal onset seizures (FOS), and primary generalized tonic-clonic seizures (PGTCS), as well as neuropsychiatric disorders including major depressive disorder (MDD), and bipolar depression (BPD). The Company is evaluating multiple therapeutic candidates targeting Kv7, Nav1.7, and Nav1.1 across various indications.

AI analysis of Xenon Pharmaceuticals Inc (XENE)

hold

Xenon Pharmaceuticals is currently priced at $59.99, with a recent RSI of 38.054 indicating it is oversold. However, the company reported a significant net income loss of -$110.736 million in Q2 2026, which raises concerns about its financial health. While the stock has seen a year-to-date increase of +34.84%, the recent insider selling activity has surged by 904.19%, which could signal a lack of confidence among insiders. Given these factors, it may be prudent to hold off on buying until there are clearer signs of recovery and stability.

Analyst Ratings (3)

-9.83% downside
Buy
3 Buy
0 Hold
0 Sell
Current: 59.99
Low
44.00
Average
54.09
High
62.00

JPMorgan

2026-05-27

Price Target

$82

Neutral

Wells Fargo

2026-05-10

Price Target

$69

Overweight

Needham

2026-05-08

Price Target

$78

Buy

Wedbush

2026-03-10

Price Target

$64

Outperform

Deutsche Bank

2026-03-10

Price Target

$90

Buy

Valuation Metrics

The current forward P/E ratio for Xenon Pharmaceuticals Inc (XENE) is 0.00, compared to its 5-year average forward P/E of -12.31.

Forward P/E

Strongly Overvalued
5Y Average P/E
-12.31
Current P/E
0.00
Overvalued
-9.67
Undervalued
-14.94

Forward EV/EBITDA

Strongly Overvalued
5Y Average EV/EBITDA
-7.50
Current EV/EBITDA
0.00
Overvalued
-3.87
Undervalued
-11.12

Forward P/S

Fair
5Y Average P/S
2119.51
Current P/S
209.91
Overvalued
5752.09
Undervalued
-1513.07

Whales holding XENE

R

Rock Springs Capital Management LP

+ HoldingXENE

+18.51%

3M Return

L

Logos Global Management, L.P.

+ HoldingXENE

+17.53%

3M Return

A

Affinity Asset Advisors, LLC

+ HoldingXENE

+14.65%

3M Return

A

Avoro Capital Advisors LLC

+ HoldingXENE

+13.10%

3M Return

V

Vestal Point Capital, LP

+ HoldingXENE

+10.94%

3M Return

O

OrbiMed Advisors LLC

+ HoldingXENE

+5.01%

3M Return

Events Timeline

2026-08-26 (ET)

14:00:00

Biohaven Enters Global Licensing Agreement with SK Biopharmaceuticals

2026-05-07 (ET)

16:40:00

Xenon Announces Positive Results from X-TOLE2 Study

2026-04-19 (ET)

20:50:00

Xenon Pharmaceuticals Presents Positive Data on Azetukalner at Neurology Annual Meeting

2026-03-11 (ET)

06:00:00

Deal Size Increased to $650M in Common Stock

2026-03-09 (ET)

16:20:00

Major Averages Volatile Amid Oil Price Spike

News

XENE FAQ — answered by Alphio AI

Xenon Pharmaceuticals Inc. is a Canada-based neuroscience-focused biopharmaceutical company committed to discovering, developing, and commercializing therapeutics to improve the lives of people living with neurological and psychiatric disorders. The Company is advancing a novel product pipeline to address areas of high unmet medical need, including epilepsy and depression. Azetukalner, a novel, highly potent, selective Kv7 potassium channel opener, represents the advanced, clinically validated potassium channel modulator in late-stage clinical development for the treatment of multiple indications that include epilepsy, including focal onset seizures (FOS), and primary generalized tonic-clonic seizures (PGTCS), as well as neuropsychiatric disorders including major depressive disorder (MDD), and bipolar depression (BPD). The Company is evaluating multiple therapeutic candidates targeting Kv7, Nav1.7, and Nav1.1 across various indications. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Xenon Pharmaceuticals is currently priced at $59.99, with a recent RSI of 38.054 indicating it is oversold. However, the company reported a significant net income loss of -$110.736 million in Q2 2026, which raises concerns about its financial health. While the stock has seen a year-to-date increase of +34.84%, the recent insider selling activity has surged by 904.19%, which could signal a lack of confidence among insiders. Given these factors, it may be prudent to hold off on buying until there are clearer signs of recovery and stability.

3 analysts cover XENE: 3 rate it Buy, 0 Hold and 0 Sell. The average price target is 54.09.

This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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