Xenon Pharmaceuticals Inc

Xenon Pharmaceuticals Inc (XENE) Stock Analysis

$36.340

+0.334 (+0.92%)At close

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High
36.620
Open
35.710
VWAP
36.11
Volume
2.13M
Mkt Cap
2.82B
Low
35.370
Amount
76.96M
EV/EBITDA, TTM
0.00

Xenon Pharmaceuticals Inc. is a Canada-based neuroscience-focused biopharmaceutical company committed to discovering, developing, and commercializing therapeutics to improve the lives of people living with neurological and psychiatric disorders. The Company is advancing a novel product pipeline to address areas of high unmet medical need, including epilepsy and depression. Azetukalner, a novel, highly potent, selective Kv7 potassium channel opener, represents the advanced, clinically validated potassium channel modulator in late-stage clinical development for the treatment of multiple indications that include epilepsy, including focal onset seizures (FOS), and primary generalized tonic-clonic seizures (PGTCS), as well as neuropsychiatric disorders including major depressive disorder (MDD), and bipolar depression (BPD). The Company is evaluating multiple therapeutic candidates targeting Kv7, Nav1.7, and Nav1.1 across various indications.

AI analysis of Xenon Pharmaceuticals Inc (XENE)

Hold

Xenon Pharmaceuticals is currently not a strong buy due to its recent stock decline and ongoing clinical trial issues, despite having a solid cash position of $1.25 billion. The stock is currently priced at $35.34, which is significantly below the analyst target of $73 from Guggenheim, indicating potential upside. However, the RSI is at 44.25, suggesting it is nearing oversold conditions, and the stock has seen a 25% drop due to a pause in clinical trials, which poses a significant risk. Therefore, while there is potential for recovery, caution is advised due to the recent volatility and uncertainty surrounding its clinical programs.

Analyst Ratings (3)

+48.84% upside
Buy
3 Buy
0 Hold
0 Sell
Current: 36.34
Low
44.00
Average
54.09
High
62.00

Guggenheim

2026-10-05

Price Target

$73

Buy

TD Cowen

2026-09-18

Price Target

$42.30

Buy

Baird

2026-09-18

Price Target

$90

Outperform

Needham

2026-09-18

Price Target

$60

Buy

Wells Fargo

2026-09-18

Price Target

$64

Overweight

Valuation Metrics

The current forward P/E ratio for Xenon Pharmaceuticals Inc (XENE) is 0.00, compared to its 5-year average forward P/E of -12.28.

Forward P/E

Strongly Overvalued
5Y Average P/E
-12.28
Current P/E
0.00
Overvalued
-9.71
Undervalued
-14.84

Forward EV/EBITDA

Strongly Overvalued
5Y Average EV/EBITDA
-7.77
Current EV/EBITDA
0.00
Overvalued
-4.38
Undervalued
-11.16

Forward P/S

Fair
5Y Average P/S
2122.14
Current P/S
128.42
Overvalued
5753.26
Undervalued
-1508.99

Whales holding XENE

A

Algert Global LLC

+ HoldingXENE

+1.76%

3M Return

D

Deerfield Management Company, L.P.

+ HoldingXENE

-1.74%

3M Return

O

OrbiMed Advisors LLC

+ HoldingXENE

-6.33%

3M Return

R

Rock Springs Capital Management LP

+ HoldingXENE

-6.35%

3M Return

A

Avoro Capital Advisors LLC

+ HoldingXENE

-7.06%

3M Return

D

Driehaus Capital Management LLC

+ HoldingXENE

-10.46%

3M Return

Events Timeline

2026-10-05 (ET)

19:30:00

Nasdaq Hits Record Highs, S&P 500 Up 0.7%

2026-09-18 (ET)

16:30:00

Middle East War Influences Energy Prices and Markets

12:30:00

Stocks Drop as Treasury Yields Rebound

12:30:00

Xenon Pharmaceuticals Stock Drops 28.9% to $40.75

11:25:00

Xenon Pharmaceuticals Shares Drop 29.8% to $40.27

News

XENE FAQ — answered by Alphio AI

Xenon Pharmaceuticals Inc. is a Canada-based neuroscience-focused biopharmaceutical company committed to discovering, developing, and commercializing therapeutics to improve the lives of people living with neurological and psychiatric disorders. The Company is advancing a novel product pipeline to address areas of high unmet medical need, including epilepsy and depression. Azetukalner, a novel, highly potent, selective Kv7 potassium channel opener, represents the advanced, clinically validated potassium channel modulator in late-stage clinical development for the treatment of multiple indications that include epilepsy, including focal onset seizures (FOS), and primary generalized tonic-clonic seizures (PGTCS), as well as neuropsychiatric disorders including major depressive disorder (MDD), and bipolar depression (BPD). The Company is evaluating multiple therapeutic candidates targeting Kv7, Nav1.7, and Nav1.1 across various indications. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Xenon Pharmaceuticals is currently not a strong buy due to its recent stock decline and ongoing clinical trial issues, despite having a solid cash position of $1.25 billion. The stock is currently priced at $35.34, which is significantly below the analyst target of $73 from Guggenheim, indicating potential upside. However, the RSI is at 44.25, suggesting it is nearing oversold conditions, and the stock has seen a 25% drop due to a pause in clinical trials, which poses a significant risk. Therefore, while there is potential for recovery, caution is advised due to the recent volatility and uncertainty surrounding its clinical programs.

3 analysts cover XENE: 3 rate it Buy, 0 Hold and 0 Sell. The average price target is 54.09.

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