Taysha Gene Therapies Inc

Taysha Gene Therapies Inc (TSHA) Stock Analysis

$3.620

-0.107 (-2.95%)At close

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High
3.745
Open
3.730
VWAP
3.65
Volume
2.75M
Mkt Cap
404.89M
Low
3.600
Amount
10.06M
EV/EBITDA, TTM
-1.49

Taysha Gene Therapies Inc is a clinical-stage biotechnology company, which is focused on advancing adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system. The Company’s lead clinical program, TSHA-102, is in development for the treatment of Rett syndrome, a rare neurodevelopmental disorder. The Company is evaluating TSHA-102 in the REVEALPhase I/II adolescent and adult clinical trial, which is a first-in-human, open-label, randomized, dose escalation and dose-expansion, multicenter study evaluating the safety and preliminary efficacy of TSHA-102 in female patients aged 12-years and older with Rett syndrome. It has acquired a worldwide right to a clinical-stage, intrathecally dosed AAV9 gene therapy program, TSHA-120, for the treatment of giant axonal neuropathy (GAN). TSHA-105 is a gene replacement therapy in development for the treatment of SLC13A5 deficiency, a rare autosomal recessive epileptic encephalopathy.

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AI analysis of Taysha Gene Therapies Inc (TSHA)

Hold

Taysha Gene Therapies Inc is currently not a good buy due to its low current price of $3.62, which is significantly below analyst price targets ranging from $10 to $15. However, the stock is experiencing high volatility with an RSI of 24.29, indicating it may be oversold. The main risk is the negative earnings trend, with a net income loss of $46.6 million in Q2 2026, which raises concerns about the company's financial health.

Valuation Metrics

The current forward P/E ratio for Taysha Gene Therapies Inc (TSHA) is 0.00, compared to its 5-year average forward P/E of -4.25.

Forward P/E

Overvalued
5Y Average P/E
-4.25
Current P/E
0.00
Overvalued
-1.18
Undervalued
-7.31

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-2.73
Current EV/EBITDA
-1.49
Overvalued
-0.45
Undervalued
-5.00

Forward P/S

Fair
5Y Average P/S
51.30
Current P/S
61.84
Overvalued
109.38
Undervalued
-6.78

Alphio AI Price Scenarios for TSHA

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%TSHA

$1.65

Scenario price

B

Base

Base · 50%TSHA

$1.30

Scenario price

B

Bear

Bear · 25%TSHA

$1.10

Scenario price

Whales holding TSHA

R

Rice Hall James & Associates, LLC

+ HoldingTSHA

-0.61%

3M Return

C

Casdin Capital, LLC

+ HoldingTSHA

-5.77%

3M Return

R

RTW Investments, LP

+ HoldingTSHA

-11.31%

3M Return

A

ADAR1 Capital Management, LLC

+ HoldingTSHA

-16.51%

3M Return

A

Artal Group S.A.

+ HoldingTSHA

-20.00%

3M Return

Events Timeline

2026-08-11 (ET)

16:30:00

Taysha CEO Highlights TSHA-102 Clinical Progress

2026-08-03 (ET)

08:30:00

Taysha and Catalent Sign Commercial Supply Agreement for TSHA-102

2026-07-13 (ET)

12:30:00

Taysha Gene Therapies Shares Down 11% to $5.64

2026-06-24 (ET)

23:30:00

Baird Prices Offering Below Last Close of $6.94

20:00:00

Micron Technology Shares Rise 14.4%, Boosting Semiconductor Sector

News

TSHA FAQ — answered by Alphio AI

Taysha Gene Therapies Inc is a clinical-stage biotechnology company, which is focused on advancing adeno-associated virus (AAV)-based gene therapies for severe monogenic diseases of the central nervous system. The Company’s lead clinical program, TSHA-102, is in development for the treatment of Rett syndrome, a rare neurodevelopmental disorder. The Company is evaluating TSHA-102 in the REVEALPhase I/II adolescent and adult clinical trial, which is a first-in-human, open-label, randomized, dose escalation and dose-expansion, multicenter study evaluating the safety and preliminary efficacy of TSHA-102 in female patients aged 12-years and older with Rett syndrome. It has acquired a worldwide right to a clinical-stage, intrathecally dosed AAV9 gene therapy program, TSHA-120, for the treatment of giant axonal neuropathy (GAN). TSHA-105 is a gene replacement therapy in development for the treatment of SLC13A5 deficiency, a rare autosomal recessive epileptic encephalopathy. It operates in the Healthcare sector (BIOLOGICAL PRODUCTS, (NO DISGNOSTIC SUBSTANCES) industry).

Taysha Gene Therapies Inc is currently not a good buy due to its low current price of $3.62, which is significantly below analyst price targets ranging from $10 to $15. However, the stock is experiencing high volatility with an RSI of 24.29, indicating it may be oversold. The main risk is the negative earnings trend, with a net income loss of $46.6 million in Q2 2026, which raises concerns about the company's financial health.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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