Soleno Therapeutics Inc

Soleno Therapeutics Inc (SLNO) Stock Analysis

$53.010

+0.021 (+0.04%)At close

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High
53.010
Open
52.990
VWAP
53.00
Vol
4.97M
Mkt Cap
1.54B
Low
52.980
Amount
263.35M
EV/EBITDA, TTM
11.60

Soleno Therapeutics, Inc. is focused on the development and commercialization of novel therapeutics for the treatment of rare diseases. Its first commercial product, VYKAT XR (diazoxide choline) extended-release tablets, is a once-daily oral treatment for hyperphagia in adults and children four years of age and older with Prader-Willi syndrome (PWS). VYKAT XR contains diazoxide choline, a potent ATP-sensitive potassium (KATP) channel activator. The KATP channels play a central role in the regulation of a number of physiological processes which may otherwise be dysregulated, contributing to the pathophysiology of several diseases. In the context of the underlying genetic or structural defects in PWS, these pathophysiological processes may cumulatively contribute to increases in appetite and aggressive food seeking, lack of satiety, accumulation of excess body fat and the establishment and perpetuation of the obese state. PWS is a rare, complex genetic neurobehavioral/metabolic disorder.

soleno.life

AI analysis of Soleno Therapeutics Inc (SLNO)

sell

SLNO is not a good buy right now for a beginner-focused, long-term investor with $50,000-$100,000 to deploy. The stock is trading essentially at the $53 acquisition price, so the upside is capped and the expected return from here is minimal. Since the user is unwilling to wait for a better entry, this is still not attractive because the current price already reflects the deal value. Best direct call: do not buy SLNO now.

Analyst Ratings (1)

+108.45% upside
Buy
1 Buy
0 Hold
0 Sell
Current: 53.01
Low
75.00
Average
110.50
High
125.00

Wells Fargo

2026-04-17

Price Target

$53

Equal Weight

H.C. Wainwright

2026-04-08

Price Target

$53

Neutral

Piper Sandler

2026-04-07

Price Target

$53

Neutral

TD Cowen

2026-04-07

Price Target

$53

Hold

Stifel

2026-04-07

Price Target

$53

Hold

Valuation Metrics

The current forward P/E ratio for Soleno Therapeutics Inc (SLNO) is 13.12, compared to its 5-year average forward P/E of -3.21.

Forward P/E

Fair
5Y Average P/E
-3.21
Current P/E
13.12
Overvalued
17.19
Undervalued
-23.61

Forward EV/EBITDA

Overvalued
5Y Average EV/EBITDA
2.41
Current EV/EBITDA
11.60
Overvalued
8.69
Undervalued
-3.86

Forward P/S

Fair
5Y Average P/S
78.37
Current P/S
4.12
Overvalued
314.20
Undervalued
-157.47

Whales holding SLNO

B

Braidwell LP

+ HoldingSLNO

+38.79%

3M Return

C

Commodore Capital LP

+ HoldingSLNO

+34.35%

3M Return

R

Rock Springs Capital Management LP

+ HoldingSLNO

+18.51%

3M Return

I

Integral Health Asset Management, LLC

+ HoldingSLNO

+15.08%

3M Return

A

Avoro Capital Advisors LLC

+ HoldingSLNO

+13.10%

3M Return

D

Deep Track Capital, LP

+ HoldingSLNO

-3.79%

3M Return

Events Timeline

2026-05-18 (ET)

08:50:00

Neurocrine Completes Acquisition of Soleno

2026-04-08 (ET)

08:50:00

Significant Increases in Indicative Borrow Rates for Liquid Options

2026-04-06 (ET)

16:40:00

Major Averages Rise as US-Iran Ceasefire Talks Emerge

16:30:00

Oppenheimer Downgrades Soleno to Perform Amid $2.9B Acquisition

News

SLNO FAQ — answered by Alphio AI

Soleno Therapeutics, Inc. is focused on the development and commercialization of novel therapeutics for the treatment of rare diseases. Its first commercial product, VYKAT XR (diazoxide choline) extended-release tablets, is a once-daily oral treatment for hyperphagia in adults and children four years of age and older with Prader-Willi syndrome (PWS). VYKAT XR contains diazoxide choline, a potent ATP-sensitive potassium (KATP) channel activator. The KATP channels play a central role in the regulation of a number of physiological processes which may otherwise be dysregulated, contributing to the pathophysiology of several diseases. In the context of the underlying genetic or structural defects in PWS, these pathophysiological processes may cumulatively contribute to increases in appetite and aggressive food seeking, lack of satiety, accumulation of excess body fat and the establishment and perpetuation of the obese state. PWS is a rare, complex genetic neurobehavioral/metabolic disorder. It operates in the Healthcare sector (ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS industry).

SLNO is not a good buy right now for a beginner-focused, long-term investor with $50,000-$100,000 to deploy. The stock is trading essentially at the $53 acquisition price, so the upside is capped and the expected return from here is minimal. Since the user is unwilling to wait for a better entry, this is still not attractive because the current price already reflects the deal value. Best direct call: do not buy SLNO now.

1 analysts cover SLNO: 1 rate it Buy, 0 Hold and 0 Sell. The average price target is 110.50.

This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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