Silence Therapeutics PLC

Silence Therapeutics PLC (SLN) Stock Analysis

$8.870

-0.717 (-8.08%)At close

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High
9.565
Open
9.530
VWAP
9.05
Volume
1.45M
Mkt Cap
886.54M
Low
8.710
Amount
13.12M
EV/EBITDA, TTM
-6.76

Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.

AI analysis of Silence Therapeutics PLC (SLN)

Buy

Silence Therapeutics PLC (SLN) is a good buy right now due to its recent positive developments and potential for growth. The current price is $9.86, and despite a recent 5-day decline of 7.33%, the stock has shown a year-to-date increase of 60.33%. The RSI is at 27.501, indicating that the stock is oversold, which could present a buying opportunity. Additionally, the gross margin has significantly improved to 97.39% in the latest quarter, reflecting strong operational efficiency. However, a key risk is the ongoing net losses, with a reported loss of $12.27 million in Q2 2026, which could impact investor sentiment in the short term.

Valuation Metrics

The current forward P/E ratio for Silence Therapeutics PLC (SLN) is 0.00, compared to its 5-year average forward P/E of -14.68.

Forward P/E

Overvalued
5Y Average P/E
-14.68
Current P/E
0.00
Overvalued
-0.41
Undervalued
-28.94

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-4.82
Current EV/EBITDA
-6.76
Overvalued
-0.21
Undervalued
-9.43

Forward P/S

Strongly Overvalued
5Y Average P/S
67.57
Current P/S
799.15
Overvalued
250.92
Undervalued
-115.78

Alphio AI Price Scenarios for SLN

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%SLN

$2.94

Scenario price

B

Base

Base · 50%SLN

$2.39

Scenario price

B

Bear

Bear · 25%SLN

$1.80

Scenario price

Whales holding SLN

T

TCG Crossover Management, LLC

+ HoldingSLN

-31.12%

3M Return

Events Timeline

2026-08-12 (ET)

09:00:00

Significant Increases in Borrow Rates for Liquid Options

2026-08-10 (ET)

17:00:00

Jefferies, Morgan Stanley, and Others Jointly Manage Proposed Offering

08:00:00

Silence Therapeutics Reports Positive Phase 2 Results for Divesiran

07:30:00

SLN365 and SLN098 Preclinical Data Updates

2026-05-18 (ET)

16:20:00

Silence Therapeutics Files $300M Ordinary Shares Offering

News

SLN FAQ — answered by Alphio AI

Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Silence Therapeutics PLC (SLN) is a good buy right now due to its recent positive developments and potential for growth. The current price is $9.86, and despite a recent 5-day decline of 7.33%, the stock has shown a year-to-date increase of 60.33%. The RSI is at 27.501, indicating that the stock is oversold, which could present a buying opportunity. Additionally, the gross margin has significantly improved to 97.39% in the latest quarter, reflecting strong operational efficiency. However, a key risk is the ongoing net losses, with a reported loss of $12.27 million in Q2 2026, which could impact investor sentiment in the short term.

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