Rhythm Pharmaceuticals Inc

Rhythm Pharmaceuticals Inc (RYTM) Stock Analysis

$107.170

-5.101 (-4.76%)At close

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High
114.750
Open
110.210
VWAP
109.67
Vol
441.21K
Mkt Cap
2.45B
Low
107.090
Amount
48.39M
EV/EBITDA, TTM
-20.17

Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company's lead asset, IMCIVREE, is an MC4R agonist designed to treat hyperphagia and severe obesity, is approved by the Food and Drug Administration (FDA) to reduce excess body weight and maintain reduction long term in adults and pediatric patients aged four years and older with acquired hypothalamic obesity, adult and pediatric patients two years of age and older with syndromic or monogenic obesity due to Bardet-Biedl syndrome (BBS) or genetically confirmed pro-opiomelanocortin (POMC), including proprotein convertase subtilisin/kexin type 1 (PCSK1), deficiency or leptin receptor (LEPR) deficiency. In addition to it the Company is advancing a broad clinical development program for setmelanotide in other rare diseases, as well as investigational MC4R agonists bivamelagon and RM-718, and a preclinical suite of small molecules for the treatment of congenital hyperinsulinism.

rhythmtx.com

AI analysis of Rhythm Pharmaceuticals Inc (RYTM)

hold

Rhythm Pharmaceuticals Inc is currently a hold. The current price is $107.17, with a gross margin of 26.52% reported for Q2 2026, which is significantly lower than previous quarters. The forward P/E ratio is not applicable, indicating potential volatility. However, the recent approval of IMCIVREE in Japan could drive future growth, as it opens up a new market for the company. The main risk is the declining gross margin, which has dropped from over 90% in previous quarters to 26.52% in the latest report, indicating potential challenges in maintaining profitability.

Analyst Ratings (4)

+31.21% upside
Buy
3 Buy
1 Hold
0 Sell
Current: 107.17
Low
123.00
Average
140.62
High
167.00

Deutsche Bank

2026-08-28

Price Target

$120

Hold

Canaccord

2026-08-05

Price Target

$154

Buy

RBC Capital

2026-08-05

Price Target

$155

Outperform

Citi

2026-08-05

Price Target

$143

Buy

Citizens

2026-08-05

Price Target

$160

Outperform

Valuation Metrics

The current forward P/E ratio for Rhythm Pharmaceuticals Inc (RYTM) is 0.00, compared to its 5-year average forward P/E of -12.93.

Forward P/E

Overvalued
5Y Average P/E
-12.93
Current P/E
0.00
Overvalued
-3.06
Undervalued
-22.80

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-12.36
Current EV/EBITDA
-20.17
Overvalued
-1.17
Undervalued
-23.54

Forward P/S

Fair
5Y Average P/S
21.98
Current P/S
13.81
Overvalued
36.02
Undervalued
7.94

Alphio AI Price Scenarios for RYTM

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%RYTM

$80.41

Scenario price

B

Base

Base · 50%RYTM

$76.83

Scenario price

B

Bear

Bear · 25%RYTM

$61.13

Scenario price

Whales holding RYTM

B

Baker Bros. Advisors LP

+ HoldingRYTM

+18.95%

3M Return

R

Rock Springs Capital Management LP

+ HoldingRYTM

+18.51%

3M Return

L

Logos Global Management, L.P.

+ HoldingRYTM

+17.53%

3M Return

S

Sofinnova Investments, Inc.

+ HoldingRYTM

+15.48%

3M Return

I

Integral Health Asset Management, LLC

+ HoldingRYTM

+15.08%

3M Return

D

Duquesne Family Office LLC

+ HoldingRYTM

+9.41%

3M Return

Events Timeline

2026-06-14 (ET)

17:00:00

Rhythm Pharmaceuticals Releases Preliminary Data on Prader-Willi Syndrome Trial

2026-05-05 (ET)

07:40:00

Rhythm Pharmaceuticals Q1 Revenue $60.11M, Exceeds Expectations

07:40:00

Rhythm Advances MC4R Agonism Pipeline

2026-05-04 (ET)

09:10:00

Rhythm Pharmaceuticals Presents New Data, Pediatric Patients' BMI Improves by 16.4%

2026-05-01 (ET)

07:10:00

Rhythm Pharmaceuticals Secures EU Approval for Imcivree to Treat Acquired Hypothalamic Obesity

News

RYTM FAQ — answered by Alphio AI

Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company's lead asset, IMCIVREE, is an MC4R agonist designed to treat hyperphagia and severe obesity, is approved by the Food and Drug Administration (FDA) to reduce excess body weight and maintain reduction long term in adults and pediatric patients aged four years and older with acquired hypothalamic obesity, adult and pediatric patients two years of age and older with syndromic or monogenic obesity due to Bardet-Biedl syndrome (BBS) or genetically confirmed pro-opiomelanocortin (POMC), including proprotein convertase subtilisin/kexin type 1 (PCSK1), deficiency or leptin receptor (LEPR) deficiency. In addition to it the Company is advancing a broad clinical development program for setmelanotide in other rare diseases, as well as investigational MC4R agonists bivamelagon and RM-718, and a preclinical suite of small molecules for the treatment of congenital hyperinsulinism. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Rhythm Pharmaceuticals Inc is currently a hold. The current price is $107.17, with a gross margin of 26.52% reported for Q2 2026, which is significantly lower than previous quarters. The forward P/E ratio is not applicable, indicating potential volatility. However, the recent approval of IMCIVREE in Japan could drive future growth, as it opens up a new market for the company. The main risk is the declining gross margin, which has dropped from over 90% in previous quarters to 26.52% in the latest report, indicating potential challenges in maintaining profitability.

4 analysts cover RYTM: 3 rate it Buy, 1 Hold and 0 Sell. The average price target is 140.62.

This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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