Rhythm Pharmaceuticals Inc

Rhythm Pharmaceuticals Inc (RYTM) Stock Analysis

$86.170

-1.766 (-2.05%)At close

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High
88.620
Open
88.200
VWAP
86.90
Volume
367.04K
Mkt Cap
2.45B
Low
85.910
Amount
31.90M
EV/EBITDA, TTM
-15.61

Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company's lead asset, IMCIVREE, is an MC4R agonist designed to treat hyperphagia and severe obesity, is approved by the Food and Drug Administration (FDA) to reduce excess body weight and maintain reduction long term in adults and pediatric patients aged four years and older with acquired hypothalamic obesity, adult and pediatric patients two years of age and older with syndromic or monogenic obesity due to Bardet-Biedl syndrome (BBS) or genetically confirmed pro-opiomelanocortin (POMC), including proprotein convertase subtilisin/kexin type 1 (PCSK1), deficiency or leptin receptor (LEPR) deficiency. In addition to it the Company is advancing a broad clinical development program for setmelanotide in other rare diseases, as well as investigational MC4R agonists bivamelagon and RM-718, and a preclinical suite of small molecules for the treatment of congenital hyperinsulinism.

rhythmtx.com

AI analysis of Rhythm Pharmaceuticals Inc (RYTM)

Hold

Rhythm Pharmaceuticals is currently a hold. The stock is priced at $86.17, significantly below analyst price targets, with the highest target at $159, suggesting substantial upside potential. However, the stock's RSI is at 25.888, indicating it is oversold, and the forward P/E ratio is extremely high at 526.32, which raises concerns about future earnings expectations. The recent insider selling trend, which increased by 288.14%, poses a risk to the stock's performance.

Analyst Ratings (4)

+63.19% upside
Buy
3 Buy
1 Hold
0 Sell
Current: 86.17
Low
123.00
Average
140.62
High
167.00

H.C. Wainwright

2026-10-12

Price Target

$130

Buy

BofA

2026-10-09

Price Target

$150

Buy

RBC Capital

2026-10-08

Price Target

$159

Outperform

Leerink

2026-09-14

Price Target

$133

Outperform

Deutsche Bank

2026-08-28

Price Target

$120

Hold

Valuation Metrics

The current forward P/E ratio for Rhythm Pharmaceuticals Inc (RYTM) is 526.32, compared to its 5-year average forward P/E of 2.47.

Forward P/E

Strongly Overvalued
5Y Average P/E
2.47
Current P/E
526.32
Overvalued
94.24
Undervalued
-89.30

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-12.78
Current EV/EBITDA
-15.61
Overvalued
-1.72
Undervalued
-23.84

Forward P/S

Undervalued
5Y Average P/S
20.06
Current P/S
10.72
Overvalued
28.83
Undervalued
11.29

Alphio AI Price Scenarios for RYTM

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%RYTM

$80.41

Scenario price

B

Base

Base · 50%RYTM

$76.83

Scenario price

B

Bear

Bear · 25%RYTM

$61.13

Scenario price

Whales holding RYTM

B

Braidwell LP

+ HoldingRYTM

+15.28%

3M Return

D

Duquesne Family Office LLC

+ HoldingRYTM

+8.54%

3M Return

S

Sofinnova Investments, Inc.

+ HoldingRYTM

+7.79%

3M Return

I

Integral Health Asset Management, LLC

+ HoldingRYTM

-8.91%

3M Return

O

OrbiMed Advisors LLC

+ HoldingRYTM

-12.22%

3M Return

R

Rock Springs Capital Management LP

+ HoldingRYTM

-12.27%

3M Return

RYTM FAQ — answered by Alphio AI

Rhythm Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company's lead asset, IMCIVREE, is an MC4R agonist designed to treat hyperphagia and severe obesity, is approved by the Food and Drug Administration (FDA) to reduce excess body weight and maintain reduction long term in adults and pediatric patients aged four years and older with acquired hypothalamic obesity, adult and pediatric patients two years of age and older with syndromic or monogenic obesity due to Bardet-Biedl syndrome (BBS) or genetically confirmed pro-opiomelanocortin (POMC), including proprotein convertase subtilisin/kexin type 1 (PCSK1), deficiency or leptin receptor (LEPR) deficiency. In addition to it the Company is advancing a broad clinical development program for setmelanotide in other rare diseases, as well as investigational MC4R agonists bivamelagon and RM-718, and a preclinical suite of small molecules for the treatment of congenital hyperinsulinism. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Rhythm Pharmaceuticals is currently a hold. The stock is priced at $86.17, significantly below analyst price targets, with the highest target at $159, suggesting substantial upside potential. However, the stock's RSI is at 25.888, indicating it is oversold, and the forward P/E ratio is extremely high at 526.32, which raises concerns about future earnings expectations. The recent insider selling trend, which increased by 288.14%, poses a risk to the stock's performance.

4 analysts cover RYTM: 3 rate it Buy, 1 Hold and 0 Sell. The average price target is 140.62.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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