Pyxis Oncology Inc

Pyxis Oncology Inc (PYXS) Stock Analysis

$3.230

-0.088 (-2.71%)At close

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High
3.380
Open
3.320
VWAP
3.27
Vol
211.99K
Mkt Cap
189.03M
Low
3.200
Amount
693.18K
EV/EBITDA, TTM
-15.00

Pyxis Oncology, Inc. is a clinical-stage company focused on developing therapeutics to target difficult-to-treat cancers. The Company is building therapeutics that hold the potential for mono and combination therapies. Its clinical program portfolio includes micvotobart pelidotin (MICVO), PYX-106, Sotigalimab (PYX-107), PYX-203, PYX-102, and APX601. The Company’s lead product candidate, MICVO, is an antibody-drug conjugate (ADC) that targets Extradomain-B Fibronectin (EDB+FN), a non-cellular structural component of the tumor extra-cellular matrix (ECM). MICVO is designed to generate a multi-pronged attack on difficult-to-treat cancers by directly killing cancer cells, reducing ECM density, inhibiting tumor angiogenesis and mobilizing an anti-tumor immune response. The Company’s ADC, MICVO, consists of human Immunoglobulin G1 (IgG1) and is site-specifically conjugated with a cleavable linker and a microtubule inhibitor (optimized auristatin) payload.

AI analysis of Pyxis Oncology Inc (PYXS)

buy

Pyxis Oncology Inc is a good buy right now due to its current price of $3.23, which is significantly below the analyst price targets of $12 from Wells Fargo and $6 from Wedbush. The company has shown a strong year-to-date change of +180.87%, indicating robust momentum. However, the main risk is its negative earnings per share (EPS) of -0.40 reported recently, which reflects ongoing financial challenges.

Valuation Metrics

The current forward P/E ratio for Pyxis Oncology Inc (PYXS) is 0.00, compared to its 5-year average forward P/E of -1.93.

Forward P/E

Overvalued
5Y Average P/E
-1.93
Current P/E
0.00
Overvalued
-0.37
Undervalued
-3.49

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
5.46
Current EV/EBITDA
-15.00
Overvalued
153.76
Undervalued
-142.85

Forward P/S

Fair
5Y Average P/S
63.61
Current P/S
99.69
Overvalued
204.28
Undervalued
-77.06

Alphio AI Price Scenarios for PYXS

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%PYXS

$1.30

Scenario price

B

Base

Base · 50%PYXS

$1.09

Scenario price

B

Bear

Bear · 25%PYXS

$0.88

Scenario price

Whales holding PYXS

B

BVF Partners L.P.

+ HoldingPYXS

+11.78%

3M Return

Events Timeline

2026-08-20 (ET)

16:30:00

Selling Stockholders Plan to Sell Up to 39.2M Shares

2026-08-13 (ET)

07:30:00

Pyxis Oncology Strengthens Financial Position with Q2 Financing

2026-06-30 (ET)

08:00:00

Pyxis Oncology Completes $50M Private Placement Financing

2026-05-14 (ET)

07:10:00

Pyxis Oncology to Update MICVO Data Mid-2026

2026-04-17 (ET)

16:10:00

Pyxis Oncology Presents New Data Showing MICVO Effective in Head and Neck Cancer Model

News

PYXS FAQ — answered by Alphio AI

Pyxis Oncology, Inc. is a clinical-stage company focused on developing therapeutics to target difficult-to-treat cancers. The Company is building therapeutics that hold the potential for mono and combination therapies. Its clinical program portfolio includes micvotobart pelidotin (MICVO), PYX-106, Sotigalimab (PYX-107), PYX-203, PYX-102, and APX601. The Company’s lead product candidate, MICVO, is an antibody-drug conjugate (ADC) that targets Extradomain-B Fibronectin (EDB+FN), a non-cellular structural component of the tumor extra-cellular matrix (ECM). MICVO is designed to generate a multi-pronged attack on difficult-to-treat cancers by directly killing cancer cells, reducing ECM density, inhibiting tumor angiogenesis and mobilizing an anti-tumor immune response. The Company’s ADC, MICVO, consists of human Immunoglobulin G1 (IgG1) and is site-specifically conjugated with a cleavable linker and a microtubule inhibitor (optimized auristatin) payload. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Pyxis Oncology Inc is a good buy right now due to its current price of $3.23, which is significantly below the analyst price targets of $12 from Wells Fargo and $6 from Wedbush. The company has shown a strong year-to-date change of +180.87%, indicating robust momentum. However, the main risk is its negative earnings per share (EPS) of -0.40 reported recently, which reflects ongoing financial challenges.

This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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