Prothena Corporation PLC

Prothena Corporation PLC (PRTA) Stock Analysis

$8.480

+0.132 (+1.56%)At close

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High
8.570
Open
8.390
VWAP
8.45
Volume
361.13K
Mkt Cap
1.10B
Low
8.310
Amount
3.05M
EV/EBITDA, TTM
-0.38

Prothena Corporation plc is an Ireland-based late-stage clinical biotechnology company. The Company is engaged in protein dysregulation and a pipeline of investigational therapeutics for rare peripheral amyloid diseases. The Company is advancing a pipeline of therapeutic candidates for a range of indications and targets to integrate scientific insights around neurological dysfunction and the biology of misfolded proteins. The Company’s pipeline includes both wholly owned and partnered programs being developed for the potential treatment of diseases, including AL amyloidosis, ATTR amyloidosis, Alzheimer’s disease, Parkinson’s disease and a range of other neurodegenerative diseases. Its clinical programs include birtamimab for the potential treatment of AL amyloidosis, prasinezumab for the potential treatment of Parkinson’s disease, NNC6019/PRX004 for the potential treatment of ATTR amyloidosis, and PRX005 and PRX012 for the potential treatment of Alzheimer’s disease.

AI analysis of Prothena Corporation PLC (PRTA)

Hold

Prothena Corporation PLC (PRTA) is currently not a strong buy due to its recent performance and technical indicators. The current price is $8.35, which is significantly lower than the analyst price target of $20, indicating potential upside. However, the RSI is at 44.158, suggesting that the stock is nearing oversold territory but has not yet reached it. The stock has a forward P/E of 10.627, which is reasonable, but the recent 1-year change of -19.48% raises concerns about its performance. The main risk is the negative net income reported in the last quarter, which was -18,583,000 USD, indicating ongoing financial challenges. Therefore, while there is potential for recovery, the current indicators suggest holding rather than buying.

Analyst Ratings (12)

+161.79% upside
Buy
12 Buy
0 Hold
0 Sell
Current: 8.48
Low
8.00
Average
22.20
High
36.00

Citizens

2026-05-08

Price Target

$20

Outperform

BofA

2025-11-24

Price Target

$8

Underperform

H.C. Wainwright

2025-11-07

Price Target

$30

Buy

Piper Sandler

2025-10-28

Price Target

$36

Overweight

Citizens JMP

2025-09-02

Price Target

$11

Outperform

Valuation Metrics

The current forward P/E ratio for Prothena Corporation PLC (PRTA) is 10.63, compared to its 5-year average forward P/E of -2.72.

Forward P/E

Fair
5Y Average P/E
-2.72
Current P/E
10.63
Overvalued
23.43
Undervalued
-28.87

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-3.59
Current EV/EBITDA
-0.38
Overvalued
4.16
Undervalued
-11.33

Forward P/S

Fair
5Y Average P/S
83.29
Current P/S
20.38
Overvalued
249.44
Undervalued
-82.86

Whales holding PRTA

A

ADAR1 Capital Management, LLC

+ HoldingPRTA

-14.67%

3M Return

Events Timeline

2026-08-06 (ET)

17:00:00

Prothena Reports Q2 Revenue of $1.01M, Exceeding Expectations

2026-05-07 (ET)

17:20:00

Prothena Updates 2026 Cash Use Projection to $18M to $23M

17:20:00

Prothena Reports Clinical Progress with Roche Collaboration

2026-04-27 (ET)

16:20:00

Prothena Receives FDA Fast Track Designation for ATTR Amyloidosis Treatment

2026-04-10 (ET)

16:10:00

Prothena Updates Leadership Team, Annie Kingston Promoted to Chief Strategy Officer

News

PRTA FAQ — answered by Alphio AI

Prothena Corporation plc is an Ireland-based late-stage clinical biotechnology company. The Company is engaged in protein dysregulation and a pipeline of investigational therapeutics for rare peripheral amyloid diseases. The Company is advancing a pipeline of therapeutic candidates for a range of indications and targets to integrate scientific insights around neurological dysfunction and the biology of misfolded proteins. The Company’s pipeline includes both wholly owned and partnered programs being developed for the potential treatment of diseases, including AL amyloidosis, ATTR amyloidosis, Alzheimer’s disease, Parkinson’s disease and a range of other neurodegenerative diseases. Its clinical programs include birtamimab for the potential treatment of AL amyloidosis, prasinezumab for the potential treatment of Parkinson’s disease, NNC6019/PRX004 for the potential treatment of ATTR amyloidosis, and PRX005 and PRX012 for the potential treatment of Alzheimer’s disease. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Prothena Corporation PLC (PRTA) is currently not a strong buy due to its recent performance and technical indicators. The current price is $8.35, which is significantly lower than the analyst price target of $20, indicating potential upside. However, the RSI is at 44.158, suggesting that the stock is nearing oversold territory but has not yet reached it. The stock has a forward P/E of 10.627, which is reasonable, but the recent 1-year change of -19.48% raises concerns about its performance. The main risk is the negative net income reported in the last quarter, which was -18,583,000 USD, indicating ongoing financial challenges. Therefore, while there is potential for recovery, the current indicators suggest holding rather than buying.

12 analysts cover PRTA: 12 rate it Buy, 0 Hold and 0 Sell. The average price target is 22.20.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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