Prime Medicine, Inc

Prime Medicine, Inc (PRME) Stock Analysis

$3.470

-0.135 (-3.88%)At close

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High
3.605
Open
3.550
VWAP
3.50
Volume
4.39M
Mkt Cap
639.76M
Low
3.410
Amount
15.35M
EV/EBITDA, TTM
-1.79

Prime Medicine, Inc. is a biotechnology company focused on developing genetic medicines designed to provide durable, and potentially curative, treatment options for patients with diseases driven by defined genetic alterations, acquired cellular dysfunction, or dysregulated gene expression. Its gene editing technology enables targeted modifications to genomic deoxyribonucleic acid (DNA) without introducing double-stranded breaks. The Company pipeline includes wholly owned in vivo programs targeting liver genetic diseases Wilson Disease, Alpha-1 Antitrypsin Deficiency (AATD) as well as early-stage discovery efforts in Cystic Fibrosis (CF). The PM359 is an ex vivo prime editing program designed to correct the GT mutation in the NCF1 gene, the most common cause of Chronic Granulomatous Disease (CGD). This program provides validation of prime editing in human cells. The Wilson Disease is a rare autosomal recessive disorder caused by loss-of-function mutations in ATP7B.

AI analysis of Prime Medicine, Inc (PRME)

Hold

Prime Medicine Inc is not a strong buy at the moment, as it is currently priced at $3.47, down 13.03% over the last 5 days, and has a negative EPS of -0.24. While analysts have set a price target of $7 to $8, indicating potential upside, the recent performance and ongoing losses present significant risks.

Valuation Metrics

The current forward P/E ratio for Prime Medicine, Inc (PRME) is 0.00, compared to its 5-year average forward P/E of -4.89.

Forward P/E

Overvalued
5Y Average P/E
-4.89
Current P/E
0.00
Overvalued
-2.13
Undervalued
-7.65

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-3.43
Current EV/EBITDA
-1.79
Overvalued
-0.21
Undervalued
-6.65

Forward P/S

Fair
5Y Average P/S
115.76
Current P/S
59.66
Overvalued
306.18
Undervalued
-74.67

Whales holding PRME

C

Casdin Capital, LLC

+ HoldingPRME

-5.77%

3M Return

A

Arch Venture Partners, L.P.

+ HoldingPRME

-21.17%

3M Return

A

Alphabet Inc.

+ HoldingPRME

-23.87%

3M Return

Events Timeline

2026-10-05 (ET)

08:30:00

Prime Medicine Initiates PM577a Clinical Trial

2026-09-24 (ET)

19:30:00

Meta Platforms Stock Rises 4.5% to Year High

16:30:00

Prime Medicine Receives FDA Clearance for PM647 Clinical Study

2026-08-06 (ET)

09:30:00

Prime Medicine Q4 Revenue $1.15M Beats Expectations

2026-07-08 (ET)

16:30:00

Stocks Broadly Down as Oil Prices Surge

News

PRME FAQ — answered by Alphio AI

Prime Medicine, Inc. is a biotechnology company focused on developing genetic medicines designed to provide durable, and potentially curative, treatment options for patients with diseases driven by defined genetic alterations, acquired cellular dysfunction, or dysregulated gene expression. Its gene editing technology enables targeted modifications to genomic deoxyribonucleic acid (DNA) without introducing double-stranded breaks. The Company pipeline includes wholly owned in vivo programs targeting liver genetic diseases Wilson Disease, Alpha-1 Antitrypsin Deficiency (AATD) as well as early-stage discovery efforts in Cystic Fibrosis (CF). The PM359 is an ex vivo prime editing program designed to correct the GT mutation in the NCF1 gene, the most common cause of Chronic Granulomatous Disease (CGD). This program provides validation of prime editing in human cells. The Wilson Disease is a rare autosomal recessive disorder caused by loss-of-function mutations in ATP7B. It operates in the Healthcare sector (BIOLOGICAL PRODUCTS, (NO DISGNOSTIC SUBSTANCES) industry).

Prime Medicine Inc is not a strong buy at the moment, as it is currently priced at $3.47, down 13.03% over the last 5 days, and has a negative EPS of -0.24. While analysts have set a price target of $7 to $8, indicating potential upside, the recent performance and ongoing losses present significant risks.

Community

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0xNetviper9/28/2026

Spent some time reflecting this morning. I broke two of my own rules. I do this from time to time, and usually the market punishes me for it. Rule one is don’t invest in BIOS or Apparel. Will be adding food to that don’t invest list. Rule 2 is don’t buy swing positions during September or October. You’ll end up becoming a holder or taking a loss. Apologies to anyone looking at trades I make, will sell $PRME soon. Doesn’t mean I don’t think it’s not a good company. Your rules won’t be my rules. Respect your rules. It will allow for the conviction you’ll need to make money.

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0xNetviper9/25/2026

$PRME 15k @ 2.96. I have been updating positions on savvy trader. Forgot to post the position here.

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