Puma Biotechnology Inc

Puma Biotechnology Inc (PBYI) Stock Analysis

$9.830

-0.645 (-6.56%)At close

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High
10.510
Open
10.510
VWAP
10.05
Volume
406.60K
Mkt Cap
155.81M
Low
9.810
Amount
4.09M
EV/EBITDA, TTM
0.00

Puma Biotechnology, Inc. is a biopharmaceutical company with a focus on the development and commercialization of products to enhance cancer care. The Company is commercializing NERLYNX, an oral version of neratinib, for the treatment of certain HER2-positive breast cancers. NERLYNX is approved in the United States for two indications: the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer following adjuvant trastuzumab-based therapy and for use in combination with capecitabine for the treatment of adult patients with advanced or metastatic HER2-positive breast cancer who have received two or more prior anti-HER2-based regimens in the metastatic setting. The Company is focused on the global development and commercialization of alisertib. Alisertib is a selective, small-molecule inhibitor of Aurora Kinase A that is designed to disrupt mitosis, leading to apoptosis of rapidly proliferating tumor cells.

AI analysis of Puma Biotechnology Inc (PBYI)

Hold

Puma Biotechnology Inc is currently trading at $9.83, which is above the analyst price target of $6, indicating that it may not be an attractive buy at this moment. The stock has a forward P/E ratio of 3.46, suggesting it is undervalued, but the RSI is at 42.73, indicating it is nearing oversold territory. The recent insider selling has increased by 230.93%, which raises concerns about future performance. Therefore, while the fundamentals show potential with a gross margin of 77.92%, the current market sentiment and insider activity suggest holding off on new purchases for now.

Analyst Ratings (9)

-64.39% Downside
Buy
8 Buy
1 Hold
0 Sell
Current: 9.83
Low
2.00
Average
3.50
High
5.00

TD Cowen

2026-08-07

Price Target

$6

Hold

HC Wainwright & Co.

2025-02-28

Price Target

$7

Strong Buy

HC Wainwright & Co.

2024-12-23

Price Target

$7

Strong Buy

HC Wainwright & Co.

2024-11-20

Price Target

$7

Strong Buy

HC Wainwright & Co.

2024-11-08

Price Target

$7

Strong Buy

Valuation Metrics

The current forward P/E ratio for Puma Biotechnology Inc (PBYI) is 3.46, compared to its 5-year average forward P/E of -73.98.

Forward P/E

Fair
5Y Average P/E
-73.98
Current P/E
3.46
Overvalued
253.01
Undervalued
-400.97

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
0.33
Current EV/EBITDA
0.00
Overvalued
11.64
Undervalued
-10.99

Forward P/S

Strongly Undervalued
5Y Average P/S
0.88
Current P/S
0.00
Overvalued
1.26
Undervalued
0.49

Alphio AI Price Scenarios for PBYI

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%PBYI

$4.01

Scenario price

B

Base

Base · 50%PBYI

$3.74

Scenario price

B

Bear

Bear · 25%PBYI

$3.50

Scenario price

Events Timeline

2026-09-17 (ET)

20:00:00

Nasdaq Composite Rises 1.7% as Fed Policy Turns Hawkish

16:30:00

Puma Biotechnology Initiates Phase II Trial for Small Cell Lung Cancer

2026-08-06 (ET)

16:30:00

Sees FY26 Net Revenue at $202M-$206M

16:30:00

Puma Reports Q2 Revenue of $56.5M, Up 8% Year-over-Year

16:30:00

Sees Q3 Royalty Revenue of $2M-$3M

News

PBYI FAQ — answered by Alphio AI

Puma Biotechnology, Inc. is a biopharmaceutical company with a focus on the development and commercialization of products to enhance cancer care. The Company is commercializing NERLYNX, an oral version of neratinib, for the treatment of certain HER2-positive breast cancers. NERLYNX is approved in the United States for two indications: the extended adjuvant treatment of adult patients with early stage HER2-overexpressed/amplified breast cancer following adjuvant trastuzumab-based therapy and for use in combination with capecitabine for the treatment of adult patients with advanced or metastatic HER2-positive breast cancer who have received two or more prior anti-HER2-based regimens in the metastatic setting. The Company is focused on the global development and commercialization of alisertib. Alisertib is a selective, small-molecule inhibitor of Aurora Kinase A that is designed to disrupt mitosis, leading to apoptosis of rapidly proliferating tumor cells. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Puma Biotechnology Inc is currently trading at $9.83, which is above the analyst price target of $6, indicating that it may not be an attractive buy at this moment. The stock has a forward P/E ratio of 3.46, suggesting it is undervalued, but the RSI is at 42.73, indicating it is nearing oversold territory. The recent insider selling has increased by 230.93%, which raises concerns about future performance. Therefore, while the fundamentals show potential with a gross margin of 77.92%, the current market sentiment and insider activity suggest holding off on new purchases for now.

9 analysts cover PBYI: 8 rate it Buy, 1 Hold and 0 Sell. The average price target is 3.50.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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