Madrigal Pharmaceuticals Inc

Madrigal Pharmaceuticals Inc (MDGL) Stock Analysis

$459.810

-0.184 (-0.04%)At close

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High
468.722
Open
464.780
VWAP
461.58
Volume
266.19K
Mkt Cap
6.09B
Low
456.220
Amount
122.87M
EV/EBITDA, TTM
-32.08

Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).

AI analysis of Madrigal Pharmaceuticals Inc (MDGL)

Buy

Madrigal Pharmaceuticals appears to be a good buy right now due to its strong sales growth momentum, with Rezdiffra achieving $364.3 million in Q2, a 71% year-over-year increase, and a current price of $471.75, significantly below analyst targets ranging from $605 to $964. The RSI is at 10.336, indicating the stock is oversold, which could present a buying opportunity. However, the main risk is the high forward P/E of 78.125, suggesting that the stock is priced for significant future growth, which may not materialize if clinical trials do not yield positive results.

Analyst Ratings (3)

+38.37% upside
Buy
3 Buy
0 Hold
0 Sell
Current: 459.81
Low
527.00
Average
636.22
High
900.00

Goldman Sachs

2026-09-24

Price Target

$704

Buy

Citi

2026-09-23

Price Target

$725

Buy

Wolfe Research

2026-08-04

Price Target

$605

Outperform

Barclays

2026-08-03

Price Target

$962

Overweight

BofA

2026-07-31

Price Target

$543

Neutral

Valuation Metrics

The current forward P/E ratio for Madrigal Pharmaceuticals Inc (MDGL) is 78.13, compared to its 5-year average forward P/E of 105.73.

Forward P/E

Fair
5Y Average P/E
105.73
Current P/E
78.13
Overvalued
380.97
Undervalued
-169.51

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-25.61
Current EV/EBITDA
-32.08
Overvalued
28.83
Undervalued
-80.06

Forward P/S

Fair
5Y Average P/S
48.69
Current P/S
4.91
Overvalued
147.67
Undervalued
-50.30

Whales holding MDGL

A

AMI Asset Management Corp

+ HoldingMDGL

+3.47%

3M Return

T

Tao Capital Management LP

+ HoldingMDGL

+3.31%

3M Return

E

Erste Asset Management GmbH

+ HoldingMDGL

+1.53%

3M Return

E

EULAV Asset Management

+ HoldingMDGL

+0.22%

3M Return

A

Armistice Capital LLC

+ HoldingMDGL

-6.13%

3M Return

I

Integral Health Asset Management, LLC

+ HoldingMDGL

-6.42%

3M Return

MDGL FAQ — answered by Alphio AI

Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c). It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Madrigal Pharmaceuticals appears to be a good buy right now due to its strong sales growth momentum, with Rezdiffra achieving $364.3 million in Q2, a 71% year-over-year increase, and a current price of $471.75, significantly below analyst targets ranging from $605 to $964. The RSI is at 10.336, indicating the stock is oversold, which could present a buying opportunity. However, the main risk is the high forward P/E of 78.125, suggesting that the stock is priced for significant future growth, which may not materialize if clinical trials do not yield positive results.

3 analysts cover MDGL: 3 rate it Buy, 0 Hold and 0 Sell. The average price target is 636.22.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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