Madrigal Pharmaceuticals Inc

Madrigal Pharmaceuticals Inc (MDGL) Stock Analysis

$434.240

-18.282 (-4.21%)At close

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High
453.550
Open
453.550
VWAP
440.37
Volume
234.85K
Mkt Cap
6.09B
Low
433.310
Amount
103.42M
EV/EBITDA, TTM
-32.25

Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).

AI analysis of Madrigal Pharmaceuticals Inc (MDGL)

Buy

Madrigal Pharmaceuticals is a good buy right now due to its strong sales growth momentum, with Rezdiffra achieving $364.3 million in Q2, a 71% year-over-year increase. Additionally, the stock is currently priced at $434.24, significantly below analyst price targets ranging from $605 to $964, indicating potential upside. However, the current RSI of 24.769 suggests the stock is oversold, which could present a buying opportunity. The main risk is the forward P/E ratio of 78.125, indicating high expectations for future earnings that may not materialize.

Analyst Ratings (3)

+46.51% upside
Buy
3 Buy
0 Hold
0 Sell
Current: 434.24
Low
527.00
Average
636.22
High
900.00

Goldman Sachs

2026-09-24

Price Target

$704

Buy

Citi

2026-09-23

Price Target

$725

Buy

Wolfe Research

2026-08-04

Price Target

$605

Outperform

Barclays

2026-08-03

Price Target

$962

Overweight

BofA

2026-07-31

Price Target

$543

Neutral

Valuation Metrics

The current forward P/E ratio for Madrigal Pharmaceuticals Inc (MDGL) is 78.13, compared to its 5-year average forward P/E of 106.11.

Forward P/E

Fair
5Y Average P/E
106.11
Current P/E
78.13
Overvalued
381.14
Undervalued
-168.92

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-25.76
Current EV/EBITDA
-32.25
Overvalued
28.64
Undervalued
-80.16

Forward P/S

Fair
5Y Average P/S
48.67
Current P/S
4.94
Overvalued
147.62
Undervalued
-50.27

Whales holding MDGL

A

AMI Asset Management Corp

+ HoldingMDGL

+1.73%

3M Return

P

Pictet Asset Management (Europe) S.A.

+ HoldingMDGL

+0.38%

3M Return

P

Paulson & Co. Inc.

+ HoldingMDGL

+0.28%

3M Return

J

Journey Strategic Wealth LLC

+ HoldingMDGL

+0.13%

3M Return

E

EULAV Asset Management

+ HoldingMDGL

-3.07%

3M Return

S

Schroder Unit Trusts Limited

+ HoldingMDGL

-4.29%

3M Return

MDGL FAQ — answered by Alphio AI

Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c). It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Madrigal Pharmaceuticals is a good buy right now due to its strong sales growth momentum, with Rezdiffra achieving $364.3 million in Q2, a 71% year-over-year increase. Additionally, the stock is currently priced at $434.24, significantly below analyst price targets ranging from $605 to $964, indicating potential upside. However, the current RSI of 24.769 suggests the stock is oversold, which could present a buying opportunity. The main risk is the forward P/E ratio of 78.125, indicating high expectations for future earnings that may not materialize.

3 analysts cover MDGL: 3 rate it Buy, 0 Hold and 0 Sell. The average price target is 636.22.

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