Krystal Biotech Inc

Krystal Biotech Inc (KRYS) Stock Analysis

$359.360

+8.086 (+2.25%)At close

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High
363.520
Open
348.620
VWAP
356.01
Vol
222.78K
Mkt Cap
5.22B
Low
345.140
Amount
79.31M
EV/EBITDA, TTM
30.53

Krystal Biotech, Inc. is an integrated, commercial-stage biotechnology company. The Company is focused on the discovery, development, and commercialization of genetic medicines to treat diseases with high unmet medical needs. Its product candidates in various stages of clinical and preclinical development include KB407, KB408, KB707, KB105, KB801, KB803, KB304 and KB301. Its commercial product, VYJUVEK, is a redosable gene therapy, and a genetic medicine approved in the United States and Europe for the treatment of dystrophic epidermolysis bullosa. KB407 is being developed for the treatment of Cystic Fibrosis. KB408 is being developed for the treatment of Alpha-1 Antitrypsin Deficiency, a rare lung disease. KB707 is being developed for the treatment of solid tumors. KB105 is being developed for TGM1-Deficient Autosomal Recessive Congenital Ichthyosis. KB803 is a redosable eye drop formulation of B-VEC, designed for the treatment of ocular complications.

AI analysis of Krystal Biotech Inc (KRYS)

buy

Krystal Biotech Inc is a good buy right now due to its strong financial performance, evidenced by a gross margin of 94.60% in Q2 2026 and a year-to-date price change of +42.34%. The current price of $351.46 is well below the average analyst price target of $386, suggesting significant upside potential. However, the main risk is the forward P/E ratio of 43.29, which indicates that the stock is trading at a high valuation relative to its earnings.

Analyst Ratings (1)

-36.21% downside
Buy
1 Buy
0 Hold
0 Sell
Current: 359.36
Low
198.00
Average
229.25
High
278.00

BofA

2026-08-04

Price Target

$392

Buy

Citi

2026-08-04

Price Target

$386

Buy

BofA

2026-07-14

Price Target

$396

Buy

TD Cowen

2026-06-18

Price Target

$403

Buy

H.C. Wainwright

2026-06-16

Price Target

$361

Buy

Valuation Metrics

The current forward P/E ratio for Krystal Biotech Inc (KRYS) is 43.10, compared to its 5-year average forward P/E of -5.42.

Forward P/E

Fair
5Y Average P/E
-5.42
Current P/E
43.10
Overvalued
64.62
Undervalued
-75.47

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
19.24
Current EV/EBITDA
30.53
Overvalued
64.00
Undervalued
-25.51

Forward P/S

Fair
5Y Average P/S
165.74
Current P/S
15.89
Overvalued
745.31
Undervalued
-413.83

Alphio AI Price Scenarios for KRYS

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%KRYS

$429.67

Scenario price

B

Base

Base · 50%KRYS

$283.64

Scenario price

B

Bear

Bear · 25%KRYS

$273.98

Scenario price

Whales holding KRYS

S

Soleus Capital Management, L.P.

+ HoldingKRYSUTHR

+16.53%

3M Return

A

Avoro Capital Advisors LLC

+ HoldingKRYS

+14.08%

3M Return

B

Bellevue Asset Management AG

+ HoldingKRYS

+11.29%

3M Return

H

Hood River Capital Management LLC

+ HoldingKRYS

-11.09%

3M Return

Events Timeline

2026-08-03 (ET)

09:30:00

Stock Futures Rise as Investors Improve Risk Appetite

08:00:00

Krystal Biotech Q2 Revenue $119.22M, Below Consensus

2026-07-20 (ET)

17:30:00

Berkshire Hathaway Acquires Taylor Morrison Home

2026-05-18 (ET)

08:20:00

Krystal Biotech Receives UK Approval for Vyjuvek to Treat Skin Disease

News

KRYS FAQ — answered by Alphio AI

Krystal Biotech, Inc. is an integrated, commercial-stage biotechnology company. The Company is focused on the discovery, development, and commercialization of genetic medicines to treat diseases with high unmet medical needs. Its product candidates in various stages of clinical and preclinical development include KB407, KB408, KB707, KB105, KB801, KB803, KB304 and KB301. Its commercial product, VYJUVEK, is a redosable gene therapy, and a genetic medicine approved in the United States and Europe for the treatment of dystrophic epidermolysis bullosa. KB407 is being developed for the treatment of Cystic Fibrosis. KB408 is being developed for the treatment of Alpha-1 Antitrypsin Deficiency, a rare lung disease. KB707 is being developed for the treatment of solid tumors. KB105 is being developed for TGM1-Deficient Autosomal Recessive Congenital Ichthyosis. KB803 is a redosable eye drop formulation of B-VEC, designed for the treatment of ocular complications. It operates in the Healthcare sector (BIOLOGICAL PRODUCTS, (NO DISGNOSTIC SUBSTANCES) industry).

Krystal Biotech Inc is a good buy right now due to its strong financial performance, evidenced by a gross margin of 94.60% in Q2 2026 and a year-to-date price change of +42.34%. The current price of $351.46 is well below the average analyst price target of $386, suggesting significant upside potential. However, the main risk is the forward P/E ratio of 43.29, which indicates that the stock is trading at a high valuation relative to its earnings.

1 analysts cover KRYS: 1 rate it Buy, 0 Hold and 0 Sell. The average price target is 229.25.

This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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