Iovance Biotherapeutics Inc

Iovance Biotherapeutics Inc (IOVA) Stock Analysis

$13.620

-1.017 (-7.47%)At close

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High
14.710
Open
14.650
VWAP
13.95
Volume
12.19M
Mkt Cap
2.24B
Low
13.515
Amount
170.09M
EV/EBITDA, TTM
-24.89

Iovance Biotherapeutics, Inc. is a commercial biotechnology company. The Company is focused on developing and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer. Its products include Amtagvi and Proleukin. Amtagvi is indicated for the treatment of adult patients with melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor, with or without a MEK inhibitor. It is marketing Proleukin (aldesleukin), an interleukin-2 (IL-2) product used in the Amtagvi treatment regimen and in other applications. Amtagvi and Proleukin are part of a treatment regimen that includes lymphodepletion. Its development pipeline includes multicenter trials of TIL cell therapies in additional treatment settings and indications for solid tumor cancers. Its TIL therapy includes melanoma, non-small cell lung cancer and gynecologic cancer.

AI analysis of Iovance Biotherapeutics Inc (IOVA)

Buy

Iovance Biotherapeutics Inc is a good buy right now due to its recent revenue guidance increase to $410-$420 million, reflecting a nearly 60% growth from last year, and a current price of $13.62, which is below several analyst price targets, including $20 from H.C. Wainwright. The stock has shown a strong year-to-date change of +440.48%, indicating robust momentum. However, the main risk is its negative earnings per share (EPS) of -0.11 reported last quarter, which highlights ongoing losses.

Analyst Ratings (7)

-30.25% Downside
Buy
7 Buy
0 Hold
0 Sell
Current: 13.62
Low
1.50
Average
9.50
High
17.00

Baird

2026-10-08

Price Target

$11

Neutral

Wells Fargo

2026-09-30

Price Target

$18

Overweight

H.C. Wainwright

2026-09-29

Price Target

$20

Buy

Barclays

2026-09-17

Price Target

$15

Overweight

TD Cowen

2026-08-25

Price Target

$10

Buy

Valuation Metrics

The current forward P/E ratio for Iovance Biotherapeutics Inc (IOVA) is 0.00, compared to its 5-year average forward P/E of -5.49.

Forward P/E

Strongly Overvalued
5Y Average P/E
-5.49
Current P/E
0.00
Overvalued
-2.83
Undervalued
-8.16

Forward EV/EBITDA

Strongly Undervalued
5Y Average EV/EBITDA
-5.00
Current EV/EBITDA
-24.89
Overvalued
-1.13
Undervalued
-8.87

Forward P/S

Fair
5Y Average P/S
43.58
Current P/S
11.23
Overvalued
171.42
Undervalued
-84.27

Alphio AI Price Scenarios for IOVA

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%IOVA

$5.72

Scenario price

B

Base

Base · 50%IOVA

$4.08

Scenario price

B

Bear

Bear · 25%IOVA

$3.72

Scenario price

Whales holding IOVA

I

Invenomic Capital Management LP

+ HoldingIOVA

+2.73%

3M Return

Events Timeline

2026-10-01 (ET)

07:30:00

Iovance Biotherapeutics Appoints Noah Berkowitz as Chief Medical Officer

2026-09-29 (ET)

17:00:00

Major Averages Decline as 30-Year Bond Yield Hits Highest Level Since 2002

12:30:00

Iovance Biotherapeutics Stock Rises 27.8% to $14.05

12:00:00

Major Averages Dip as 30-Year Bond Yield Hits Highest Level Since 2002

10:30:00

Iovance Biotherapeutics Stock Rises 25.9% to $13.84

News

IOVA FAQ — answered by Alphio AI

Iovance Biotherapeutics, Inc. is a commercial biotechnology company. The Company is focused on developing and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer. Its products include Amtagvi and Proleukin. Amtagvi is indicated for the treatment of adult patients with melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor, with or without a MEK inhibitor. It is marketing Proleukin (aldesleukin), an interleukin-2 (IL-2) product used in the Amtagvi treatment regimen and in other applications. Amtagvi and Proleukin are part of a treatment regimen that includes lymphodepletion. Its development pipeline includes multicenter trials of TIL cell therapies in additional treatment settings and indications for solid tumor cancers. Its TIL therapy includes melanoma, non-small cell lung cancer and gynecologic cancer. It operates in the Healthcare sector (BIOLOGICAL PRODUCTS, (NO DISGNOSTIC SUBSTANCES) industry).

Iovance Biotherapeutics Inc is a good buy right now due to its recent revenue guidance increase to $410-$420 million, reflecting a nearly 60% growth from last year, and a current price of $13.62, which is below several analyst price targets, including $20 from H.C. Wainwright. The stock has shown a strong year-to-date change of +440.48%, indicating robust momentum. However, the main risk is its negative earnings per share (EPS) of -0.11 reported last quarter, which highlights ongoing losses.

7 analysts cover IOVA: 7 rate it Buy, 0 Hold and 0 Sell. The average price target is 9.50.

Community

More ↗
lunarviper9/25/2026

Fresh analyst support is putting $IOVA's Amtagvi story back in focus. A popular financial services firm has resumed coverage with a Buy rating and a $15 price target, pointing to improving commercial execution around Amtagvi. Key takeaways: - Amtagvi generated about $91M in Q2 sales, treating roughly 150 patients - Operational hurdles around treatment availability are starting to ease - A proprietary physician survey indicated strong demand and interest in Amtagvi for second-line melanoma - The latest view suggests Amtagvi could be entering a more meaningful commercial growth phase

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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