Ionis Pharmaceuticals Inc (IONS) FinancialsIONSFinancialIonis Pharmaceuticals Inc

Ionis Pharmaceuticals, Inc. (IONS) generates its revenue through a diversified portfolio of business segments. Currently, the largest contributor to its top-line growth is Ionis core, accounting for 80.7% of total sales, equivalent to $234.34M. Other significant revenue streams include R&D revenue under collaborative agreements and Akcea Therapeutics. Understanding this composition is critical for investors evaluating how IONS navigates market cycles within the Biotechnology & Medical Research industry.

Evaluating the bottom line, Ionis Pharmaceuticals, Inc. maintains a gross margin of 98.98%. This metric reflects the company's pricing power and manufacturing efficiency. Further down the income statement, the operating margin stands at -38.18%, while the net margin is -42.79%. These profitability ratios, combined with a Return on Equity (ROE) of -105.50%, provide a clear picture of how effectively IONS converts its operational activities into shareholder value.

In the context of the broader market, IONS competes directly with industry leaders such as CYTK and RGEN. With a market capitalization of $9.51B, it holds a significant position in the sector. When comparing efficiency, IONS's gross margin of 98.98% stands against CYTK's 80.46% and RGEN's 53.91%. Such benchmarking helps identify whether Ionis Pharmaceuticals, Inc. is trading at a premium or discount relative to its financial performance.

Ionis has demonstrated strong revenue growth, with total revenue reaching 267949000 USD in Q2 2026, and a gross margin consistently above 96%. However, it has faced challenges with net income, showing significant losses in recent quarters.