Ionis Pharmaceuticals Inc (IONS) FinancialsIONSIonis Pharmaceuticals Inc

Ionis Pharmaceuticals, Inc. (IONS) generates its revenue through a diversified portfolio of business segments. Currently, the largest contributor to its top-line growth is Ionis core, accounting for 80.7% of total sales, equivalent to $234.34M. Other significant revenue streams include R&D revenue under collaborative agreements and Akcea Therapeutics. Understanding this composition is critical for investors evaluating how IONS navigates market cycles within the Biotechnology & Medical Research industry.

Evaluating the bottom line, Ionis Pharmaceuticals, Inc. maintains a gross margin of 98.98%. This metric reflects the company's pricing power and manufacturing efficiency. Further down the income statement, the operating margin stands at -38.18%, while the net margin is -40.30%. These profitability ratios, combined with a Return on Equity (ROE) of -105.50%, provide a clear picture of how effectively IONS converts its operational activities into shareholder value.

In the context of the broader market, IONS competes directly with industry leaders such as ALKS and SYRE. With a market capitalization of $7.14B, it holds a significant position in the sector. When comparing efficiency, IONS's gross margin of 98.98% stands against ALKS's 75.67% and SYRE's N/A. Such benchmarking helps identify whether Ionis Pharmaceuticals, Inc. is trading at a premium or discount relative to its financial performance.

Ionis has shown a gross margin of 98.98% in Q2 2026, which is strong, but the company has also reported significant net income losses, including a loss of $114.646 million in Q2 2026. The current ratio is healthy at 7.89, indicating good liquidity.