Axsome Therapeutics, Inc.

Axsome Therapeutics, Inc. (AXSM) Stock Analysis

$199.020

-6.986 (-3.51%)At close

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High
205.700
Open
205.700
VWAP
201.24
Vol
441.31K
Mkt Cap
3.80B
Low
199.000
Amount
88.81M
EV/EBITDA, TTM
-29.92

Axsome Therapeutics, Inc. is a fully integrated biopharmaceutical company. The Company focused on developing medicines for people impacted by central nervous system (CNS) conditions. Its commercial products include AUVELITY, SUNOSI, and SYMBRAVO. It is also advancing pipeline of novel product candidates in early- to late-stage development addressing a broad range of serious neurological and psychiatric conditions. Its product pipelines include AXS-05, AXS-12, and AXS-14. Its lead product candidate, AXS-05 (dextromethorphan-bupropion), is developed for the treatment of Alzheimer’s disease (AD) agitation and smoking cessation. Its AXS-12 (reboxetine) is a novel, oral, potent, highly selective investigational norepinephrine reuptake inhibitor (NRI) and cortical dopamine modulator being developed for the treatment of narcolepsy. Its AXS-14 (esreboxetine) is a novel, oral, potent, highly selective investigational NRI being developed for the management of fibromyalgia.

AI analysis of Axsome Therapeutics, Inc. (AXSM)

hold

Axsome Therapeutics is currently a hold. The stock has a current price of $199.02 and an RSI of 19.79, indicating it is oversold. However, the forward P/E ratio is extremely high at 370.37, suggesting that the stock may be overvalued at this time. While the company reported a strong 46% year-over-year revenue increase in Q2, reaching $218.4 million, and has a gross margin of 93.06%, the significant net losses and high forward P/E ratio raise concerns about its valuation. The main risk is the high forward P/E ratio of 370.37, which could indicate that the stock is overvalued if growth does not meet expectations.

Analyst Ratings (2)

+5.29% upside
Buy
2 Buy
0 Hold
0 Sell
Current: 199.02
Low
153.00
Average
209.54
High
260.00

Mizuho

2026-08-12

Price Target

$316

Outperform

RBC Capital

2026-08-11

Price Target

$297

Outperform

Morgan Stanley

2026-08-11

Price Target

$251

Equal Weight

Wells Fargo

2026-08-11

Price Target

$256

Overweight

Guggenheim

2026-08-11

Price Target

$275

Buy

Valuation Metrics

The current forward P/E ratio for Axsome Therapeutics, Inc. (AXSM) is 370.37, compared to its 5-year average forward P/E of 23.69.

Forward P/E

Strongly Overvalued
5Y Average P/E
23.69
Current P/E
370.37
Overvalued
148.20
Undervalued
-100.82

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-20.27
Current EV/EBITDA
-29.92
Overvalued
63.23
Undervalued
-103.76

Forward P/S

Fair
5Y Average P/S
340.80
Current P/S
6.92
Overvalued
2801.14
Undervalued
-2119.54

Alphio AI Price Scenarios for AXSM

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%AXSM

$200.39

Scenario price

B

Base

Base · 50%AXSM

$153.74

Scenario price

B

Bear

Bear · 25%AXSM

$131.38

Scenario price

Whales holding AXSM

S

Sofinnova Investments, Inc.

+ HoldingAXSM

+15.48%

3M Return

I

Integral Health Asset Management, LLC

+ HoldingAXSM

+15.08%

3M Return

R

Readystate Asset Management LP

+ HoldingAXSM

+11.43%

3M Return

S

Samlyn Capital, LLC

+ HoldingAXSM

+6.63%

3M Return

P

Perceptive Advisors LLC

+ HoldingAXSM

+4.39%

3M Return

I

IFP Advisors, LLC

+ HoldingAXSM

+1.03%

3M Return

Events Timeline

2026-08-10 (ET)

07:30:00

Axsome Reports Q2 Revenue of $218.38M, Below Expectations

2026-07-15 (ET)

07:31:00

Axsome Therapeutics AXS-12 New Drug Application Accepted by FDA

2026-06-26 (ET)

07:30:00

Axsome Therapeutics Doses First Patient in FOCUS-3 Trial

2026-06-03 (ET)

07:30:00

Axsome Therapeutics Resolves Sunosi Patent Litigation

News

AXSM FAQ — answered by Alphio AI

Axsome Therapeutics, Inc. is a fully integrated biopharmaceutical company. The Company focused on developing medicines for people impacted by central nervous system (CNS) conditions. Its commercial products include AUVELITY, SUNOSI, and SYMBRAVO. It is also advancing pipeline of novel product candidates in early- to late-stage development addressing a broad range of serious neurological and psychiatric conditions. Its product pipelines include AXS-05, AXS-12, and AXS-14. Its lead product candidate, AXS-05 (dextromethorphan-bupropion), is developed for the treatment of Alzheimer’s disease (AD) agitation and smoking cessation. Its AXS-12 (reboxetine) is a novel, oral, potent, highly selective investigational norepinephrine reuptake inhibitor (NRI) and cortical dopamine modulator being developed for the treatment of narcolepsy. Its AXS-14 (esreboxetine) is a novel, oral, potent, highly selective investigational NRI being developed for the management of fibromyalgia. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Axsome Therapeutics is currently a hold. The stock has a current price of $199.02 and an RSI of 19.79, indicating it is oversold. However, the forward P/E ratio is extremely high at 370.37, suggesting that the stock may be overvalued at this time. While the company reported a strong 46% year-over-year revenue increase in Q2, reaching $218.4 million, and has a gross margin of 93.06%, the significant net losses and high forward P/E ratio raise concerns about its valuation. The main risk is the high forward P/E ratio of 370.37, which could indicate that the stock is overvalued if growth does not meet expectations.

2 analysts cover AXSM: 2 rate it Buy, 0 Hold and 0 Sell. The average price target is 209.54.

This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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