Axsome Therapeutics, Inc.

Axsome Therapeutics, Inc. (AXSM) Stock Analysis

$156.320

-9.113 (-5.83%)At close

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High
166.550
Open
166.010
VWAP
159.52
Volume
1.33M
Mkt Cap
3.80B
Low
155.685
Amount
211.96M
EV/EBITDA, TTM
-24.32

Axsome Therapeutics, Inc. is a fully integrated biopharmaceutical company. The Company focused on developing medicines for people impacted by central nervous system (CNS) conditions. Its commercial products include AUVELITY, SUNOSI, and SYMBRAVO. It is also advancing pipeline of novel product candidates in early- to late-stage development addressing a broad range of serious neurological and psychiatric conditions. Its product pipelines include AXS-05, AXS-12, and AXS-14. Its lead product candidate, AXS-05 (dextromethorphan-bupropion), is developed for the treatment of Alzheimer’s disease (AD) agitation and smoking cessation. Its AXS-12 (reboxetine) is a novel, oral, potent, highly selective investigational norepinephrine reuptake inhibitor (NRI) and cortical dopamine modulator being developed for the treatment of narcolepsy. Its AXS-14 (esreboxetine) is a novel, oral, potent, highly selective investigational NRI being developed for the management of fibromyalgia.

AI analysis of Axsome Therapeutics, Inc. (AXSM)

Hold

Axsome Therapeutics is currently a hold. The stock is trading at $168.35 with a forward P/E ratio of 32.15, indicating potential for growth, but it has a low RSI of 7.84, suggesting it is oversold. The company reported a significant revenue increase of 66% year-over-year, reaching approximately $638.5 million for FY 2025, but it still faces challenges with a net loss of $183.2 million, which raises concerns about profitability.

Analyst Ratings (2)

+34.05% upside
Buy
2 Buy
0 Hold
0 Sell
Current: 156.32
Low
153.00
Average
209.54
High
260.00

RBC Capital

2026-10-08

Price Target

$295

Outperform

Deutsche Bank

2026-09-29

Price Target

$267

Buy

Morgan Stanley

2026-09-25

Price Target

$247

Equal Weight

Truist

2026-09-23

Price Target

$285

Buy

H.C. Wainwright

2026-08-31

Price Target

$290

Buy

Valuation Metrics

The current forward P/E ratio for Axsome Therapeutics, Inc. (AXSM) is 32.15, compared to its 5-year average forward P/E of 25.51.

Forward P/E

Fair
5Y Average P/E
25.51
Current P/E
32.15
Overvalued
151.02
Undervalued
-99.99

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-20.78
Current EV/EBITDA
-24.32
Overvalued
62.67
Undervalued
-104.23

Forward P/S

Fair
5Y Average P/S
19.75
Current P/S
5.60
Overvalued
60.92
Undervalued
-21.42

Alphio AI Price Scenarios for AXSM

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%AXSM

$200.39

Scenario price

B

Base

Base · 50%AXSM

$153.74

Scenario price

B

Bear

Bear · 25%AXSM

$131.38

Scenario price

Whales holding AXSM

I

IFP Advisors, LLC

+ HoldingAXSM

+7.87%

3M Return

S

Sofinnova Investments, Inc.

+ HoldingAXSM

+7.70%

3M Return

W

Weiss Asset Management, LLC

+ HoldingAXSM

+0.96%

3M Return

G

Granite Investment Partners, LLC

+ HoldingAXSM

+0.69%

3M Return

P

Pallas Capital Advisors LLC

+ HoldingAXSM

+0.68%

3M Return

E

Eventide Asset Management, LLC

+ HoldingAXSM

-2.86%

3M Return

AXSM FAQ — answered by Alphio AI

Axsome Therapeutics, Inc. is a fully integrated biopharmaceutical company. The Company focused on developing medicines for people impacted by central nervous system (CNS) conditions. Its commercial products include AUVELITY, SUNOSI, and SYMBRAVO. It is also advancing pipeline of novel product candidates in early- to late-stage development addressing a broad range of serious neurological and psychiatric conditions. Its product pipelines include AXS-05, AXS-12, and AXS-14. Its lead product candidate, AXS-05 (dextromethorphan-bupropion), is developed for the treatment of Alzheimer’s disease (AD) agitation and smoking cessation. Its AXS-12 (reboxetine) is a novel, oral, potent, highly selective investigational norepinephrine reuptake inhibitor (NRI) and cortical dopamine modulator being developed for the treatment of narcolepsy. Its AXS-14 (esreboxetine) is a novel, oral, potent, highly selective investigational NRI being developed for the management of fibromyalgia. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Axsome Therapeutics is currently a hold. The stock is trading at $168.35 with a forward P/E ratio of 32.15, indicating potential for growth, but it has a low RSI of 7.84, suggesting it is oversold. The company reported a significant revenue increase of 66% year-over-year, reaching approximately $638.5 million for FY 2025, but it still faces challenges with a net loss of $183.2 million, which raises concerns about profitability.

2 analysts cover AXSM: 2 rate it Buy, 0 Hold and 0 Sell. The average price target is 209.54.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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