Axsome Therapeutics, Inc.

Axsome Therapeutics, Inc. (AXSM) Stock Analysis

$157.140

-4.510 (-2.87%)At close

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High
160.430
Open
160.430
VWAP
157.89
Volume
873.15K
Mkt Cap
3.80B
Low
156.090
Amount
137.86M
EV/EBITDA, TTM
-24.22

Axsome Therapeutics, Inc. is a fully integrated biopharmaceutical company. The Company focused on developing medicines for people impacted by central nervous system (CNS) conditions. Its commercial products include AUVELITY, SUNOSI, and SYMBRAVO. It is also advancing pipeline of novel product candidates in early- to late-stage development addressing a broad range of serious neurological and psychiatric conditions. Its product pipelines include AXS-05, AXS-12, and AXS-14. Its lead product candidate, AXS-05 (dextromethorphan-bupropion), is developed for the treatment of Alzheimer’s disease (AD) agitation and smoking cessation. Its AXS-12 (reboxetine) is a novel, oral, potent, highly selective investigational norepinephrine reuptake inhibitor (NRI) and cortical dopamine modulator being developed for the treatment of narcolepsy. Its AXS-14 (esreboxetine) is a novel, oral, potent, highly selective investigational NRI being developed for the management of fibromyalgia.

AI analysis of Axsome Therapeutics, Inc. (AXSM)

Hold

Axsome Therapeutics Inc is currently not a strong buy. The current price is $157.14, with a forward P/E ratio of 32.15, indicating high future earnings expectations despite recent losses. The RSI is at 20.615, suggesting the stock is oversold, but the recent performance shows a 5-day change of -6.66% and a year-to-date change of -12.06%, indicating ongoing downward pressure. The main risk is the company's high debt-to-equity ratio of 243.05%, which could impact its financial stability moving forward.

Analyst Ratings (2)

+33.35% upside
Buy
2 Buy
0 Hold
0 Sell
Current: 157.14
Low
153.00
Average
209.54
High
260.00

RBC Capital

2026-10-08

Price Target

$295

Outperform

Deutsche Bank

2026-09-29

Price Target

$267

Buy

Morgan Stanley

2026-09-25

Price Target

$247

Equal Weight

Truist

2026-09-23

Price Target

$285

Buy

H.C. Wainwright

2026-08-31

Price Target

$290

Buy

Valuation Metrics

The current forward P/E ratio for Axsome Therapeutics, Inc. (AXSM) is 32.15, compared to its 5-year average forward P/E of 25.59.

Forward P/E

Fair
5Y Average P/E
25.59
Current P/E
32.15
Overvalued
151.03
Undervalued
-99.86

Forward EV/EBITDA

Fair
5Y Average EV/EBITDA
-20.80
Current EV/EBITDA
-24.22
Overvalued
62.61
Undervalued
-104.22

Forward P/S

Fair
5Y Average P/S
19.38
Current P/S
5.58
Overvalued
59.68
Undervalued
-20.92

Alphio AI Price Scenarios for AXSM

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%AXSM

$200.39

Scenario price

B

Base

Base · 50%AXSM

$153.74

Scenario price

B

Bear

Bear · 25%AXSM

$131.38

Scenario price

Whales holding AXSM

S

Sofinnova Investments, Inc.

+ HoldingAXSM

+7.79%

3M Return

I

IFP Advisors, LLC

+ HoldingAXSM

+5.72%

3M Return

P

Pallas Capital Advisors LLC

+ HoldingAXSM

+0.72%

3M Return

G

Granite Investment Partners, LLC

+ HoldingAXSM

-1.33%

3M Return

W

Weiss Asset Management, LLC

+ HoldingAXSM

-4.94%

3M Return

S

Samlyn Capital, LLC

+ HoldingAXSM

-7.85%

3M Return

AXSM FAQ — answered by Alphio AI

Axsome Therapeutics, Inc. is a fully integrated biopharmaceutical company. The Company focused on developing medicines for people impacted by central nervous system (CNS) conditions. Its commercial products include AUVELITY, SUNOSI, and SYMBRAVO. It is also advancing pipeline of novel product candidates in early- to late-stage development addressing a broad range of serious neurological and psychiatric conditions. Its product pipelines include AXS-05, AXS-12, and AXS-14. Its lead product candidate, AXS-05 (dextromethorphan-bupropion), is developed for the treatment of Alzheimer’s disease (AD) agitation and smoking cessation. Its AXS-12 (reboxetine) is a novel, oral, potent, highly selective investigational norepinephrine reuptake inhibitor (NRI) and cortical dopamine modulator being developed for the treatment of narcolepsy. Its AXS-14 (esreboxetine) is a novel, oral, potent, highly selective investigational NRI being developed for the management of fibromyalgia. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Axsome Therapeutics Inc is currently not a strong buy. The current price is $157.14, with a forward P/E ratio of 32.15, indicating high future earnings expectations despite recent losses. The RSI is at 20.615, suggesting the stock is oversold, but the recent performance shows a 5-day change of -6.66% and a year-to-date change of -12.06%, indicating ongoing downward pressure. The main risk is the company's high debt-to-equity ratio of 243.05%, which could impact its financial stability moving forward.

2 analysts cover AXSM: 2 rate it Buy, 0 Hold and 0 Sell. The average price target is 209.54.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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