Apogee Therapeutics, Inc.

Apogee Therapeutics, Inc. (APGE) Stock Analysis

$135.070

-0.014 (-0.01%)At close

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High
135.090
Open
135.080
VWAP
135.07
Volume
5.14M
Mkt Cap
2.25B
Low
135.060
Amount
694.56M
EV/EBITDA, TTM
0.00

Apogee Therapeutics, Inc. is a clinical-stage biotechnology company. The Company is advancing novel biologics with the potential for differentiated efficacy and dosing in the inflammatory and immunology (I&I) markets, including for the treatment of atopic dermatitis (AD), asthma, eosinophilic esophagitis (EoE), chronic obstructive pulmonary disease (COPD), and other I&I indications. APG777, the Company’s most advanced program, is being initially developed for the treatment of AD. With four validated targets in its portfolio, it is seeking to achieve efficacy and dosing through monotherapies and combinations of its novel antibodies. Its most advanced programs are APG777, APG990, APG333, and APG808. APG990 is an SQ extended half-life mAb that utilizes advanced antibody engineering to target OX40L. APG333 is a fully human mAb against thymic stromal lymphopoietin (TSLP). APG808 is an SQ extended half-life mAb targeting IL-4Ra. APG279 is for the dual inhibition of OX40L and IL-13.

AI analysis of Apogee Therapeutics, Inc. (APGE)

Hold

Apogee Therapeutics Inc (APGE) is currently trading at $134.97, which is very close to the analyst price target of $135. This indicates that the stock is fairly valued at this moment. The RSI is at 82.663, suggesting that the stock is overbought, which could lead to a price correction. Additionally, the company has reported significant net income losses, with the latest quarter showing a net loss of $85,854,000. The acquisition by AbbVie for $10.9 billion could provide long-term growth potential, but the immediate financial health appears strained due to ongoing losses and high debt obligations. The main risk is the potential dilution of earnings per share by $0.14 as a result of the acquisition financing, which could impact short-term investor sentiment.

Valuation Metrics

The current forward P/E ratio for Apogee Therapeutics, Inc. (APGE) is 0.00, compared to its 5-year average forward P/E of -12.33.

Forward P/E

Strongly Overvalued
5Y Average P/E
-12.33
Current P/E
0.00
Overvalued
-7.92
Undervalued
-16.73

Forward EV/EBITDA

Overvalued
5Y Average EV/EBITDA
-6.72
Current EV/EBITDA
0.00
Overvalued
-2.10
Undervalued
-11.34

Forward P/S

Overvalued
5Y Average P/S
241.73
Current P/S
886.01
Overvalued
726.21
Undervalued
-242.74

Alphio AI Price Scenarios for APGE

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%APGE

$44.90

Scenario price

B

Base

Base · 50%APGE

$39.91

Scenario price

B

Bear

Bear · 25%APGE

$31.96

Scenario price

Whales holding APGE

C

Cinctive Capital Management LP

+ HoldingAPGE

+4.31%

3M Return

M

Magnetar Capital Partners, LP

+ HoldingAPGE

+2.81%

3M Return

C

Centiva Capital, LP

+ HoldingAPGE

+0.45%

3M Return

S

Seven Grand Managers LLC

+ HoldingAPGE

-0.15%

3M Return

W

Whitebox Advisors LLC

+ HoldingAPGE

-0.34%

3M Return

G

Glazer Capital, LLC

+ HoldingAPGE

-2.09%

3M Return

Events Timeline

2026-09-03 (ET)

09:00:00

AbbVie Completes Acquisition of Apogee for Approximately $10.9B

2026-06-24 (ET)

10:01:00

Stifel Downgrades Apogee Therapeutics to Hold with Price Target of $135

2026-06-23 (ET)

08:30:00

RBC Raises Apogee Price Target to $135

08:30:00

Guggenheim Downgrades Apogee Therapeutics to Neutral

07:30:00

BofA Moves to No Rating on Apogee Therapeutics After AbbVie Acquisition

News

APGE FAQ — answered by Alphio AI

Apogee Therapeutics, Inc. is a clinical-stage biotechnology company. The Company is advancing novel biologics with the potential for differentiated efficacy and dosing in the inflammatory and immunology (I&I) markets, including for the treatment of atopic dermatitis (AD), asthma, eosinophilic esophagitis (EoE), chronic obstructive pulmonary disease (COPD), and other I&I indications. APG777, the Company’s most advanced program, is being initially developed for the treatment of AD. With four validated targets in its portfolio, it is seeking to achieve efficacy and dosing through monotherapies and combinations of its novel antibodies. Its most advanced programs are APG777, APG990, APG333, and APG808. APG990 is an SQ extended half-life mAb that utilizes advanced antibody engineering to target OX40L. APG333 is a fully human mAb against thymic stromal lymphopoietin (TSLP). APG808 is an SQ extended half-life mAb targeting IL-4Ra. APG279 is for the dual inhibition of OX40L and IL-13. It operates in the Healthcare sector (BIOLOGICAL PRODUCTS, (NO DISGNOSTIC SUBSTANCES) industry).

Apogee Therapeutics Inc (APGE) is currently trading at $134.97, which is very close to the analyst price target of $135. This indicates that the stock is fairly valued at this moment. The RSI is at 82.663, suggesting that the stock is overbought, which could lead to a price correction. Additionally, the company has reported significant net income losses, with the latest quarter showing a net loss of $85,854,000. The acquisition by AbbVie for $10.9 billion could provide long-term growth potential, but the immediate financial health appears strained due to ongoing losses and high debt obligations. The main risk is the potential dilution of earnings per share by $0.14 as a result of the acquisition financing, which could impact short-term investor sentiment.

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