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AN2 Therapeutics Receives FDA Clearance for New Drug Application
AN2 Therapeutics announced that the U.S. Food and Drug Administration has cleared the Company's Investigational New Drug application for epetraborole in polycythemia vera. The Company has now received regulatory clearance in all planned jurisdictions for the global study and expects to initiate the trial in the fourth quarter of 2026.
AN2 Therapeutics Receives Funding Extension from Gates Foundation
AN2 Therapeutics (ANTX) announced that the Gates Foundation has awarded an extension of funding to support AN2 Therapeutics' research activities under its ongoing tuberculosis research collaboration with GSK (GSK) focused on the development of boron-based leucyl-tRNA synthetase inhibitors.
AN2 Therapeutics to Present Epetraborole Data at SOHO 2026 Annual Meeting
The company states: "AN2 Therapeutics announced that four abstracts highlighting clinical and nonclinical data supporting the development of epetraborole, a novel boron-containing oral candidate for the treatment of polycythemia vera (PV), will be presented at the Society of Hematologic Oncology (SOHO) 2026 Annual Meeting, taking place September 9-12, 2026, at the George R. Brown Convention Center in Houston, Texas." "These abstracts provide insights into the potential beneficial hematological effects of epetraborole across both clinical and nonclinical studies and strengthen our understanding of the exposure-response relationships that we believe support its development in polycythemia vera," said George H. Talbot, M.D. Co-Founder and Senior Medical Advisor of AN2 Therapeutics.
AN2 Therapeutics Appoints Cameron Trenor as Chief Medical Officer
AN2 Therapeutics announced the appointment of Cameron Trenor, M.D., as Chief Medical Officer. Most recently, Dr. Trenor served as Chief Medical Officer of Cellarity
AN2 Therapeutics to Launch Three Phase 2 Clinical Trials
"AN2 will have three Phase 2 programs underway by the end of this year, all of which have the potential to address major unmet needs. Our near-term focus is advancing start-up activities for the Phase 2 EBO-PV-201 study in polycythemia vera. We recently held a pre-IND meeting with the FDA and are expanding the Phase 2 study to include sites in the U.S. and Australia," said Eric Easom, Co-Founder, Chairman, President and CEO of AN2 Therapeutics. "Enrollment is ongoing in an investigator-initiated Phase 2 study in M. abscessus lung disease. In our chronic Chagas program, compelling non-human primate efficacy data and a favorable clinical PK and safety profile from our Phase 1 study support planned initiation of a Phase 2 trial by year-end. We are also expanding our pipeline, having declared our first development candidate for solid tumors earlier this year and expecting to advance a second development candidate by the end of 2026. Collectively, these achievements underscore the potential of our boron chemistry platform to deliver differentiated therapies across multiple disease areas."
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