Ionis Pharmaceuticals Inc

Ionis Pharmaceuticals Inc (IONS) Stock Analysis

$61.050

-1.349 (-2.21%)At close

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High
61.690
Open
60.620
VWAP
61.03
Vol
1.85M
Mkt Cap
6.89B
Low
60.350
Amount
112.96M
EV/EBITDA, TTM
-24.60

Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.

www.ionis.com

AI analysis of Ionis Pharmaceuticals Inc (IONS)

buy

Ionis Pharmaceuticals is a good buy right now due to its recent FDA approval of Tryngolza, which is expected to significantly boost future revenues. The current price of $61.05 is below the analyst price target range of $76 to $115, indicating potential upside. Additionally, the stock has shown a 17.93% increase over the last 20 days, reflecting positive momentum. However, the main risk is the company's negative net income, which was -114646000 USD in Q2 2026, indicating ongoing financial challenges.

Analyst Ratings (15)

+51.79% upside
Hold
5 Buy
8 Hold
2 Sell
Current: 61.05
Low
65.00
Average
92.67
High
110.00

JPMorgan

2026-08-03

Price Target

$76

Overweight

H.C. Wainwright

2026-07-30

Price Target

$115

Buy

Goldman Sachs

2026-07-29

Price Target

$69

Neutral

Guggenheim

2026-07-21

Price Target

$89

Buy

Wolfe Research

2026-07-15

Price Target

Peer Perform

Valuation Metrics

The current forward P/E ratio for Ionis Pharmaceuticals Inc (IONS) is 90.91, compared to its 5-year average forward P/E of -2.80.

Forward P/E

Strongly Overvalued
5Y Average P/E
-2.80
Current P/E
90.91
Overvalued
35.28
Undervalued
-40.88

Forward EV/EBITDA

Undervalued
5Y Average EV/EBITDA
-13.38
Current EV/EBITDA
-24.60
Overvalued
-7.11
Undervalued
-19.66

Forward P/S

Fair
5Y Average P/S
9.50
Current P/S
7.40
Overvalued
11.72
Undervalued
7.27

Alphio AI Price Scenarios for IONS

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%IONS

$34.91

Scenario price

B

Base

Base · 50%IONS

$28.85

Scenario price

B

Bear

Bear · 25%IONS

$20.89

Scenario price

Whales holding IONS

B

Baker Bros. Advisors LP

+ HoldingIONS

+18.95%

3M Return

B

Bellevue Asset Management AG

+ HoldingIONS

+9.20%

3M Return

P

Perceptive Advisors LLC

+ HoldingIONS

+4.39%

3M Return

C

Capital Counsel LLC

+ HoldingIONS

+3.98%

3M Return

A

ADAR1 Capital Management, LLC

+ HoldingIONS

+2.25%

3M Return

C

C WorldWide Asset Management Fondsmaeglerselskab A/S

+ HoldingIONS

+1.50%

3M Return

IONS FAQ — answered by Alphio AI

Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Ionis Pharmaceuticals is a good buy right now due to its recent FDA approval of Tryngolza, which is expected to significantly boost future revenues. The current price of $61.05 is below the analyst price target range of $76 to $115, indicating potential upside. Additionally, the stock has shown a 17.93% increase over the last 20 days, reflecting positive momentum. However, the main risk is the company's negative net income, which was -114646000 USD in Q2 2026, indicating ongoing financial challenges.

15 analysts cover IONS: 5 rate it Buy, 8 Hold and 2 Sell. The average price target is 92.67.

本页仅供研究参考,不构成投资建议。模型可能出错。过往表现不代表未来结果。

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