Tango Therapeutics Inc

Tango Therapeutics Inc (TNGX) Stock Analysis

$22.190

-0.031 (-0.14%)At close

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High
23.020
Open
21.980
VWAP
22.24
Volume
3.44M
Mkt Cap
912.47M
Low
21.520
Amount
76.49M
EV/EBITDA, TTM
-646.24

Tango Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to discovering novel drug targets and delivering precision medicine for the treatment of cancer. The Company's novel small molecules are designed to be selectively active in cancer cells with specific genetic alterations, killing those cancer cells while sparing normal cells. The Company is focused on clinical development of two methylthioadenosine phosphorylase (MTAP)-deleted selective PRMT5 inhibitors: vopimetostat (TNG462) for non-CNS cancers, both as a monotherapy and in combination with RAS inhibitors, and TNG456, brain-penetrant protein arginine methyltransferase 5 (PRMT5) inhibitor, for CNS cancers, including glioblastoma (GBM). Its TNG260 is a first-in-class Co-repressor of the Repressor Element-1 Silencing Transcription (CoREST) inhibitor, which in preclinical studies reversed the immune evasion effect of STK11 loss-of-function mutations.

AI analysis of Tango Therapeutics Inc (TNGX)

Buy

Tango Therapeutics Inc (TNGX) appears to be a good buy right now. The current price is $23.81, and analysts have set a price target as high as $60, suggesting a potential upside of over 150%. The stock has shown impressive performance with a year-to-date change of +166.63% and a 1-year change of +181.11%. The RSI is at 57.019, indicating a healthy momentum without being overbought. However, the main risk is the high short interest at 29.53%, which could lead to volatility in the stock price.

Valuation Metrics

The current forward P/E ratio for Tango Therapeutics Inc (TNGX) is 0.00, compared to its 5-year average forward P/E of -5.13.

Forward P/E

Strongly Overvalued
5Y Average P/E
-5.13
Current P/E
0.00
Overvalued
-2.80
Undervalued
-7.47

Forward EV/EBITDA

Undervalued
5Y Average EV/EBITDA
-123.79
Current EV/EBITDA
-646.24
Overvalued
175.13
Undervalued
-422.70

Forward P/S

Overvalued
5Y Average P/S
290.62
Current P/S
1312.23
Overvalued
869.46
Undervalued
-288.22

Alphio AI Price Scenarios for TNGX

Scenario prices are the last monthly forecast band of the current year. Probabilities are fixed model weights (25 / 50 / 25), not guarantees.

B

Bull

Bull · 25%TNGX

$1.71

Scenario price

B

Base

Base · 50%TNGX

$1.55

Scenario price

B

Bear

Bear · 25%TNGX

$1.21

Scenario price

Whales holding TNGX

B

Bellevue Asset Management AG

+ HoldingTNGX

-2.06%

3M Return

A

ArrowMark Colorado Holdings, LLC

+ HoldingTNGX

-3.45%

3M Return

P

Paradigm Biocapital Advisors LP

+ HoldingTNGX

-3.78%

3M Return

D

Deerfield Management Company, L.P.

+ HoldingTNGX

-8.23%

3M Return

I

Integral Health Asset Management, LLC

+ HoldingTNGX

-8.58%

3M Return

R

RTW Investments, LP

+ HoldingTNGX

-11.48%

3M Return

Events Timeline

2026-08-15 (ET)

20:30:00

T1 Energy Short Interest Soars to 35.5%

2026-08-11 (ET)

07:30:00

Tango CEO: Vopimetostat Achieves 92% Response Rate in Pancreatic Cancer

2026-08-06 (ET)

19:00:00

Tango Therapeutics Chairman Barbara Weber Steps Down

2026-07-17 (ET)

12:30:00

Nasdaq Falls Over 1% as Chip Makers Plunge

2026-07-10 (ET)

22:00:00

Ondas Holdings Short Interest Rises to 40%

News

TNGX FAQ — answered by Alphio AI

Tango Therapeutics, Inc. is a clinical-stage biotechnology company dedicated to discovering novel drug targets and delivering precision medicine for the treatment of cancer. The Company's novel small molecules are designed to be selectively active in cancer cells with specific genetic alterations, killing those cancer cells while sparing normal cells. The Company is focused on clinical development of two methylthioadenosine phosphorylase (MTAP)-deleted selective PRMT5 inhibitors: vopimetostat (TNG462) for non-CNS cancers, both as a monotherapy and in combination with RAS inhibitors, and TNG456, brain-penetrant protein arginine methyltransferase 5 (PRMT5) inhibitor, for CNS cancers, including glioblastoma (GBM). Its TNG260 is a first-in-class Co-repressor of the Repressor Element-1 Silencing Transcription (CoREST) inhibitor, which in preclinical studies reversed the immune evasion effect of STK11 loss-of-function mutations. It operates in the Healthcare sector (PHARMACEUTICAL PREPARATIONS industry).

Tango Therapeutics Inc (TNGX) appears to be a good buy right now. The current price is $23.81, and analysts have set a price target as high as $60, suggesting a potential upside of over 150%. The stock has shown impressive performance with a year-to-date change of +166.63% and a 1-year change of +181.11%. The RSI is at 57.019, indicating a healthy momentum without being overbought. However, the main risk is the high short interest at 29.53%, which could lead to volatility in the stock price.

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This page is for research only and is not investment advice. Models can be wrong. Past performance does not guarantee future results.

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